Frontiers in Pharmacology | Pharmacology of Ion Channels and Channelopathies

Original Research

Accepted on 07 Mar 2025

The venom of Cyriopagopus schmidti spider contains a natural huwentoxin-IV analogue with unexpected improved analgesic potential

in Pharmacology of Ion Channels and Channelopathies

Aurélie Antunes
Jerome Montnach
Kuldip Khakh
Ludivine Lopez
Baptiste Thomas
Barbara Ribeiro De Oliveira-Mendes
Lucie Jaquillard
Denis Servent
Charles Cohen
Evelyne Josette BENOIT

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1566312

Review

Accepted on 07 Mar 2025

Sodium Channels as a New Target for Pain Treatment

in Pharmacology of Ion Channels and Channelopathies

Rui Chen
Liuyiran 2401900316
Liu Qian
Mingliang Yi
Hong Yin
Shun Wang
Bingbing Xiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1573254

Original Research

Published on 07 Mar 2025

Selenium reduces oxaliplatin induced neuropathic pain: focus on TRPV1

in Pharmacology of Ion Channels and Channelopathies

Bilal Çiğ

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549190

356 views

Review

Accepted on 03 Mar 2025

Recent insights on the impact of SWELL1 on metabolic syndromes

in Pharmacology of Ion Channels and Channelopathies

Mianhong Qin
Xuejie Yi
ZiQiang Duan
Tao Li
Bo Chang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1552176

Original Research

Published on 28 Feb 2025

Administration of the KCa channel activator SKA-31 improves endothelial function in the aorta of atherosclerosis-prone mice

in Pharmacology of Ion Channels and Channelopathies

O. Daniel Vera
Ramesh C. Mishra
Rayan Khaddaj-Mallat
Liam Hamm
Barak Almarzouq
Yong-Xiang Chen
Darrell D. Belke
Latika Singh
Heike Wulff
Andrew P. Braun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545050

301 views

Original Research

Published on 24 Feb 2025

Intestinal current measurement detects age-dependent differences in CFTR function in rectal epithelium

in Pharmacology of Ion Channels and Channelopathies

Simon Y. Graeber
Olaf Sommerburg
Yin Yu
Julian Berges
Stephanie Hirtz
Heike Scheuermann
Jasmin Berger
Julia Duerr
Marcus A. Mall

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537095

518 views

Review

Accepted on 21 Feb 2025

Mechanisms mediating effects of cardiotonic steroids in mammalian blood cells

in Pharmacology of Ion Channels and Channelopathies

Irina Yurievna Petrushanko
Yuri M. Poluektov
Olga Lopina
Maria A. Strelkova
Iuliia D. Kuleshova
Alexander Alexander Makarov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1520927

Review

Published on 30 Jan 2025

The enigmatic SLC26A6 multifunctional anion transporter: recent advances in structure-function relationship, pathophysiological significance and novel pharmacological inhibitors

in Pharmacology of Ion Channels and Channelopathies

Ursula E. Seidler

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1536864

710 views

Original Research

Published on 06 Jan 2025

pH-induced conformational changes in the selectivity filter of a potassium channel lead to alterations in its selectivity and permeation properties

in Pharmacology of Ion Channels and Channelopathies

Carlos Coll-Díez
Ana Marcela Giudici
Alberto Potenza
José Manuel González-Ros
José Antonio Poveda

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1499383

483 views

Original Research

Published on 18 Nov 2024

Pharmacological rescue of the G85E CFTR variant by preclinical and approved modulators

in Pharmacology of Ion Channels and Channelopathies

Valeria Tomati
Valeria Capurro
Emanuela Pesce
Cristina Pastorino
Elvira Sondo
Mariateresa Lena
Anna Borrelli
Federico Cresta
Stefano Pantano
Francesca Collini

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1494327

1,042 views
1 citation

Original Research

Published on 14 Oct 2024

GABA Type A receptors expressed in triple negative breast cancer cells mediate chloride ion flux

in Pharmacology of Ion Channels and Channelopathies

J Bundy
Y Ahmed
S Weller
J Nguyen
J Shaw
I Mercier
A Suryanarayanan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1449256

1,285 views

Original Research

Published on 09 Oct 2024

The diversity of AMPA receptor inhibition mechanisms among amidine-containing compounds

in Pharmacology of Ion Channels and Channelopathies

Arseniy S. Zhigulin
Mikhail Y. Dron
Oleg I. Barygin
Denis B. Tikhonov

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1467266

1,003 views

Review

Published on 19 Sep 2024

The role of TRPV1 in chronic prostatitis: a review

in Pharmacology of Ion Channels and Channelopathies

Zhipeng Jiang
Wen Luo
Zongmin Long
Jie Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1459683

1,566 views
1 citation

Original Research

Published on 26 Aug 2024

Endocannabinoid regulation of inward rectifier potassium (Kir) channels

in Pharmacology of Ion Channels and Channelopathies

Sultan Mayar
Mariia Borbuliak
Andreas Zoumpoulakis
Tahar Bouceba
Madeleine M. Labonté
Ameneh Ahrari
Niveny Sinniah
Mina Memarpoor-Yazdi
Catherine Vénien-Bryan
D. Peter Tieleman

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1439767

1,512 views
1 citation

Editorial

Published on 20 Aug 2024

Editorial: Reviews in pharmacology of ion channels and channelopathies

in Pharmacology of Ion Channels and Channelopathies

Jinwei Zhang
Jean-Marc Sabatier
Mohamed Chahine
Domenico Tricarico

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1449967

915 views

Review

Published on 30 Jul 2024

Unlocking the therapeutic potential of P2X7 receptor: a comprehensive review of its role in neurodegenerative disorders

in Pharmacology of Ion Channels and Channelopathies

Xiaoming Liu
Yiwen Li
Liting Huang
Yingyan Kuang
Xiaoxiong Wu
Xiangqiong Ma
Beibei Zhao
Jiao Lan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1450704

3,447 views
3 citations

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Articles

The venom of Cyriopagopus schmidti spider contains a natural huwentoxin-IV analogue with unexpected improved analgesic potential

Sodium Channels as a New Target for Pain Treatment

Selenium reduces oxaliplatin induced neuropathic pain: focus on TRPV1

Recent insights on the impact of SWELL1 on metabolic syndromes

Administration of the KCa channel activator SKA-31 improves endothelial function in the aorta of atherosclerosis-prone mice

Intestinal current measurement detects age-dependent differences in CFTR function in rectal epithelium

Mechanisms mediating effects of cardiotonic steroids in mammalian blood cells

The enigmatic SLC26A6 multifunctional anion transporter: recent advances in structure-function relationship, pathophysiological significance and novel pharmacological inhibitors

pH-induced conformational changes in the selectivity filter of a potassium channel lead to alterations in its selectivity and permeation properties

Pharmacological rescue of the G85E CFTR variant by preclinical and approved modulators

GABA Type A receptors expressed in triple negative breast cancer cells mediate chloride ion flux

The diversity of AMPA receptor inhibition mechanisms among amidine-containing compounds

The role of TRPV1 in chronic prostatitis: a review

Endocannabinoid regulation of inward rectifier potassium (Kir) channels

Editorial: Reviews in pharmacology of ion channels and channelopathies

Unlocking the therapeutic potential of P2X7 receptor: a comprehensive review of its role in neurodegenerative disorders