Frontiers in Pharmacology | Pharmacology of Ion Channels and Channelopathies

Review

Published on 24 Mar 2025

Mechanisms mediating effects of cardiotonic steroids in mammalian blood cells

in Pharmacology of Ion Channels and Channelopathies

Yuri M. Poluektov
Olga D. Lopina
Maria A. Strelkova
Iuliia D. Kuleshova
Alexander A. Makarov
Irina Yu. Petrushanko

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1520927

2,215 views
2 citations

Opinion

Published on 21 Mar 2025

When HERG-caused LQT2 encounters antisense oligonucleotide: is exon 6 skipping therapy plausible?

in Pharmacology of Ion Channels and Channelopathies

Zequn Zheng
Yongfei Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1535259

1,456 views
1 citation

Review

Published on 21 Mar 2025

Recent insights on the impact of SWELL1 on metabolic syndromes

in Pharmacology of Ion Channels and Channelopathies

Mianhong Qin
Xuejie Yi
Ziqiang Duan
Bo Chang
Tao Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1552176

2,543 views
2 citations

Original Research

Published on 07 Mar 2025

Selenium reduces oxaliplatin induced neuropathic pain: focus on TRPV1

in Pharmacology of Ion Channels and Channelopathies

Bilal Çiğ

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549190

2,573 views
1 citation

Original Research

Published on 28 Feb 2025

Administration of the KCa channel activator SKA-31 improves endothelial function in the aorta of atherosclerosis-prone mice

in Pharmacology of Ion Channels and Channelopathies

O. Daniel Vera
Ramesh C. Mishra
Rayan Khaddaj-Mallat
Liam Hamm
Barak Almarzouq
Yong-Xiang Chen
Darrell D. Belke
Latika Singh
Heike Wulff
Andrew P. Braun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545050

2,380 views

Original Research

Published on 24 Feb 2025

Intestinal current measurement detects age-dependent differences in CFTR function in rectal epithelium

in Pharmacology of Ion Channels and Channelopathies

Simon Y. Graeber
Olaf Sommerburg
Yin Yu
Julian Berges
Stephanie Hirtz
Heike Scheuermann
Jasmin Berger
Julia Duerr
Marcus A. Mall

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537095

2,958 views
3 citations

Review

Published on 30 Jan 2025

The enigmatic SLC26A6 multifunctional anion transporter: recent advances in structure-function relationship, pathophysiological significance and novel pharmacological inhibitors

in Pharmacology of Ion Channels and Channelopathies

Ursula E. Seidler

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1536864

3,578 views
1 citation

Original Research

Published on 06 Jan 2025

pH-induced conformational changes in the selectivity filter of a potassium channel lead to alterations in its selectivity and permeation properties

in Pharmacology of Ion Channels and Channelopathies

Carlos Coll-Díez
Ana Marcela Giudici
Alberto Potenza
José Manuel González-Ros
José Antonio Poveda

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1499383

1,882 views

Original Research

Published on 18 Nov 2024

Pharmacological rescue of the G85E CFTR variant by preclinical and approved modulators

in Pharmacology of Ion Channels and Channelopathies

Valeria Tomati
Valeria Capurro
Emanuela Pesce
Cristina Pastorino
Elvira Sondo
Mariateresa Lena
Anna Borrelli
Federico Cresta
Stefano Pantano
Francesca Collini

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1494327

2,581 views
3 citations

Original Research

Published on 14 Oct 2024

GABA Type A receptors expressed in triple negative breast cancer cells mediate chloride ion flux

in Pharmacology of Ion Channels and Channelopathies

J Bundy
Y Ahmed
S Weller
J Nguyen
J Shaw
I Mercier
A Suryanarayanan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1449256

2,847 views
1 citation

Original Research

Published on 09 Oct 2024

The diversity of AMPA receptor inhibition mechanisms among amidine-containing compounds

in Pharmacology of Ion Channels and Channelopathies

Arseniy S. Zhigulin
Mikhail Y. Dron
Oleg I. Barygin
Denis B. Tikhonov

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1467266

3,523 views

Review

Published on 19 Sep 2024

The role of TRPV1 in chronic prostatitis: a review

in Pharmacology of Ion Channels and Channelopathies

Zhipeng Jiang
Wen Luo
Zongmin Long
Jie Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1459683

4,151 views
4 citations

Original Research

Published on 26 Aug 2024

Endocannabinoid regulation of inward rectifier potassium (Kir) channels

in Pharmacology of Ion Channels and Channelopathies

Sultan Mayar
Mariia Borbuliak
Andreas Zoumpoulakis
Tahar Bouceba
Madeleine M. Labonté
Ameneh Ahrari
Niveny Sinniah
Mina Memarpoor-Yazdi
Catherine Vénien-Bryan
D. Peter Tieleman

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1439767

2,983 views
4 citations

Editorial

Published on 20 Aug 2024

Editorial: Reviews in pharmacology of ion channels and channelopathies

in Pharmacology of Ion Channels and Channelopathies

Jinwei Zhang
Jean-Marc Sabatier
Mohamed Chahine
Domenico Tricarico

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1449967

2,020 views

Review

Published on 30 Jul 2024

Unlocking the therapeutic potential of P2X7 receptor: a comprehensive review of its role in neurodegenerative disorders

in Pharmacology of Ion Channels and Channelopathies

Xiaoming Liu
Yiwen Li
Liting Huang
Yingyan Kuang
Xiaoxiong Wu
Xiangqiong Ma
Beibei Zhao
Jiao Lan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1450704

9,090 views
17 citations

Original Research

Published on 25 Jul 2024

Unlocking cellular traffic jams: olive oil-mediated rescue of CNG mutant channels

in Pharmacology of Ion Channels and Channelopathies

Angeles Avalos-Hernandez
Karina Juarez-Navarro
Estela Ruiz-Baca
Ivan Meneses-Morales
Edith Espino-Saldaña
Ataulfo Martinez-Torres
Angelica Lopez-Rodriguez

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1408156

5,136 views
1 citation

Review

Published on 09 Jul 2024

Therapeutic targeting of voltage-gated sodium channel NaV1.7 for cancer metastasis

in Pharmacology of Ion Channels and Channelopathies

Piyasuda Pukkanasut
Renata Jaskula-Sztul
Juan Carlos Gomora
Sadanandan E. Velu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1416705

6,794 views
8 citations

Editorial

Published on 02 Jul 2024

Editorial: Intracellular ion channels in health and disease

in Pharmacology of Ion Channels and Channelopathies

Giovanni Zifarelli
Michael Pusch
Tobias Stauber

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1430150

1,484 views
1 citation

Mini Review

Published on 01 Jul 2024

The role of potassium ion channels in chronic sinusitis

in Pharmacology of Ion Channels and Channelopathies

Changhui Ding
Senxi Gai
Zhiyong Ma
Lizhuo Yang
Zhijie Fu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1431330

5,737 views
2 citations

Original Research

Published on 26 Jun 2024

Eugenol and lidocaine inhibit voltage-gated Na+ channels from dorsal root ganglion neurons with different mechanisms

in Pharmacology of Ion Channels and Channelopathies

Luiz Moreira-Junior
Jose Henrique Leal-Cardoso
Antonio Carlos Cassola
Joao Luis Carvalho-de-Souza

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1354737

4,138 views
4 citations

Original Research

Published on 26 Jun 2024

Activation of Piezo1 or TRPV2 channels inhibits human ureteral contractions via NO release from the mucosa

in Pharmacology of Ion Channels and Channelopathies

Jianing Liu
Cong Wang
Wenyu Wang
Ning Ding
Jiaxin Liu
Hanwen Liu
Jiliang Wen
Wendong Sun
Shulu Zu
Xiulin Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1410565

9,498 views
2 citations

Editorial

Published on 18 Jun 2024

Editorial: Ion channels and transporters as drug targets in immune disorders

in Pharmacology of Ion Channels and Channelopathies

Vaibhavkumar S. Gawali
Yogesh B. Narkhede
Sachin Kumar

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1439156

1,613 views

Brief Research Report

Published on 12 Jun 2024

Cystic fibrosis: desensitization in delayed hypersensitivity reactions to elexacaftor/tezacaftor/ivacaftor

in Pharmacology of Ion Channels and Channelopathies

L. Gómez-Ganda
P. Galván-Blasco
A. Fernández-Polo
V. Cardona
B. García-Palop
CJ Parramón-Teixidó
E. Polverino
A. Álvarez-Fernández

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1392986

2,647 views
4 citations

Original Research

Published on 11 Jun 2024

Toward high-resolution modeling of small molecule–ion channel interactions

in Pharmacology of Ion Channels and Channelopathies

Brandon J. Harris
Phuong T. Nguyen
Guangfeng Zhou
Heike Wulff
Frank DiMaio
Vladimir Yarov-Yarovoy

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1411428

3,574 views
5 citations

551 articles

articles

Mechanisms mediating effects of cardiotonic steroids in mammalian blood cells

When HERG-caused LQT2 encounters antisense oligonucleotide: is exon 6 skipping therapy plausible?

Recent insights on the impact of SWELL1 on metabolic syndromes

Selenium reduces oxaliplatin induced neuropathic pain: focus on TRPV1

Administration of the KCa channel activator SKA-31 improves endothelial function in the aorta of atherosclerosis-prone mice

Intestinal current measurement detects age-dependent differences in CFTR function in rectal epithelium

The enigmatic SLC26A6 multifunctional anion transporter: recent advances in structure-function relationship, pathophysiological significance and novel pharmacological inhibitors

pH-induced conformational changes in the selectivity filter of a potassium channel lead to alterations in its selectivity and permeation properties

Pharmacological rescue of the G85E CFTR variant by preclinical and approved modulators

GABA Type A receptors expressed in triple negative breast cancer cells mediate chloride ion flux

The diversity of AMPA receptor inhibition mechanisms among amidine-containing compounds

The role of TRPV1 in chronic prostatitis: a review

Endocannabinoid regulation of inward rectifier potassium (Kir) channels

Editorial: Reviews in pharmacology of ion channels and channelopathies

Unlocking the therapeutic potential of P2X7 receptor: a comprehensive review of its role in neurodegenerative disorders

Unlocking cellular traffic jams: olive oil-mediated rescue of CNG mutant channels

Therapeutic targeting of voltage-gated sodium channel NaV1.7 for cancer metastasis

Editorial: Intracellular ion channels in health and disease

The role of potassium ion channels in chronic sinusitis

Eugenol and lidocaine inhibit voltage-gated Na+ channels from dorsal root ganglion neurons with different mechanisms

Activation of Piezo1 or TRPV2 channels inhibits human ureteral contractions via NO release from the mucosa

Editorial: Ion channels and transporters as drug targets in immune disorders

Cystic fibrosis: desensitization in delayed hypersensitivity reactions to elexacaftor/tezacaftor/ivacaftor

Toward high-resolution modeling of small molecule–ion channel interactions