Frontiers in Pharmacology | Pharmacology of Ion Channels and Channelopathies

Original Research

Published on 16 Dec 2021

Mechanisms Underlying Gastrodin Alleviating Vincristine-Induced Peripheral Neuropathic Pain

in Pharmacology of Ion Channels and Channelopathies

Xiangyu Wang
Boxuan Zhang
Xuedong Li
Xingang Liu
Songsong Wang
Yuan Xie
Jialing Pi
Zhiyuan Yang
Jincan Li
Qingzhong Jia

Frontiers in Pharmacology

doi 10.3389/fphar.2021.744663

5,482 views
17 citations

Original Research

Published on 08 Dec 2021

Inhibition of the Nav1.7 Channel in the Trigeminal Ganglion Relieves Pulpitis Inflammatory Pain

in Pharmacology of Ion Channels and Channelopathies

Minjee Kwon
Il Young Jung
Myeounghoon Cha
Bae Hwan Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2021.759730

4,949 views
10 citations

Original Research

Published on 08 Dec 2021

Unique Pharmacological Properties of α-Conotoxin OmIA at α7 nAChRs

in Pharmacology of Ion Channels and Channelopathies

Thao N.T. Ho
Nikita Abraham
Richard J. Lewis

Frontiers in Pharmacology

doi 10.3389/fphar.2021.803397

3,295 views
7 citations

Original Research

Published on 08 Dec 2021

The Na+/Ca2+ Exchanger 3 Is Functionally Coupled With the NaV1.6 Voltage-Gated Channel and Promotes an Endoplasmic Reticulum Ca2+ Refilling in a Transgenic Model of Alzheimer’s Disease

in Pharmacology of Ion Channels and Channelopathies

Ilaria Piccialli
Roselia Ciccone
Agnese Secondo
Francesca Boscia
Valentina Tedeschi
Valeria de Rosa
Pasquale Cepparulo
Lucio Annunziato
Anna Pannaccione

Frontiers in Pharmacology

doi 10.3389/fphar.2021.775271

5,240 views
15 citations

Original Research

Published on 07 Dec 2021

Screening for Activity Against AMPA Receptors Among Anticonvulsants—Focus on Phenytoin

in Pharmacology of Ion Channels and Channelopathies

M. Y. Dron
A. S. Zhigulin
D. B. Tikhonov
O. I. Barygin

Frontiers in Pharmacology

doi 10.3389/fphar.2021.775040

5,555 views
9 citations

Original Research

Published on 06 Dec 2021

A Novel Spider Toxin Inhibits Fast Inactivation of the Nav1.9 Channel by Binding to Domain III and Domain IV Voltage Sensors

in Pharmacology of Ion Channels and Channelopathies

Shuijiao Peng
Minzhi Chen
Zhen Xiao
Xin Xiao
Sen Luo
Songping Liang
Xi Zhou
Zhonghua Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.778534

4,873 views
4 citations

Original Research

Published on 02 Dec 2021

The L1624Q Variant in SCN1A Causes Familial Epilepsy Through a Mixed Gain and Loss of Channel Function

in Pharmacology of Ion Channels and Channelopathies

Laura B. Jones
Colin H. Peters
Richard E. Rosch
Maxine Owers
Elaine Hughes
Deb K. Pal
Peter C. Ruben

Frontiers in Pharmacology

doi 10.3389/fphar.2021.788192

4,467 views
6 citations

Original Research

Published on 01 Dec 2021

The Human SCN10AG1662S Point Mutation Established in Mice Impacts on Mechanical, Heat, and Cool Sensitivity

in Pharmacology of Ion Channels and Channelopathies

Celeste Chidiac
Yaping Xue
Maria del Mar Muniz Moreno
Ameer Abu Bakr Rasheed
Romain Lorentz
Marie-Christine Birling
Claire Gaveriaux-Ruff
Yann Herault

Frontiers in Pharmacology

doi 10.3389/fphar.2021.780132

5,215 views
6 citations

Original Research

Published on 01 Dec 2021

Toxic Peptide From Palythoa caribaeorum Acting on the TRPV1 Channel Prevents Pentylenetetrazol-Induced Epilepsy in Zebrafish Larvae

in Pharmacology of Ion Channels and Channelopathies

Xiufen Wang
Qiwen Liao
Hanbin Chen
Guiyi Gong
Shirley Weng In Siu
Qian Chen
Hiotong Kam
Carolina Oi Lam Ung
Kwok-Kuen Cheung
Gandhi Rádis-Baptista

Frontiers in Pharmacology

doi 10.3389/fphar.2021.763089

6,154 views
10 citations

Original Research

Published on 25 Nov 2021

Synergistic Effect of Proteinase Activity by Purification and Identification of Toxic Protease From Nemopilema nomurai

in Pharmacology of Ion Channels and Channelopathies

Chunlin Yu
Rongfeng Li
Xiujing Yin
Huahua Yu
Pengcheng Li

Frontiers in Pharmacology

doi 10.3389/fphar.2021.791847

3,712 views
10 citations

Original Research

Published on 19 Nov 2021

Loss-of-Function Piezo1 Mutations Display Altered Stability Driven by Ubiquitination and Proteasomal Degradation

in Pharmacology of Ion Channels and Channelopathies

Zijing Zhou
Jinyuan Vero Li
Boris Martinac
Charles D. Cox

Frontiers in Pharmacology

doi 10.3389/fphar.2021.766416

6,044 views
13 citations

Original Research

Published on 19 Nov 2021

Molecular Pathology of Sodium Channel Beta-Subunit Variants

in Pharmacology of Ion Channels and Channelopathies

Paweorn Angsutararux
Wandi Zhu
Taylor L. Voelker
Jonathan R. Silva

Frontiers in Pharmacology

doi 10.3389/fphar.2021.761275

5,413 views
22 citations

Correction

Published on 17 Nov 2021

Corrigendum: Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels

in Pharmacology of Ion Channels and Channelopathies

Frank S. Choveau
Ismail Ben Soussia
Delphine Bichet
Franck C. Chatelain
Sylvain Feliciangeli
Florian Lesage

Frontiers in Pharmacology

doi 10.3389/fphar.2021.795920

1,383 views
1 citation

Original Research

Published on 17 Nov 2021

Pathogenic in-Frame Variants in SCN8A: Expanding the Genetic Landscape of SCN8A-Associated Disease

in Pharmacology of Ion Channels and Channelopathies

Jennifer C. Wong
Kameryn M. Butler
Lindsey Shapiro
Jacquelyn T. Thelin
Kari A. Mattison
Kathryn B. Garber
Paula C. Goldenberg
Shobana Kubendran
G. Bradley Schaefer
Andrew Escayg

Frontiers in Pharmacology

doi 10.3389/fphar.2021.748415

4,377 views
4 citations

Review

Published on 10 Nov 2021

Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression

in Pharmacology of Ion Channels and Channelopathies

Emine Eren-Koçak
Turgay Dalkara

Frontiers in Pharmacology

doi 10.3389/fphar.2021.777607

11,249 views
29 citations

Original Research

Published on 04 Nov 2021

Intersegment Contacts of Potentially Damaging Variants of Cardiac Sodium Channel

in Pharmacology of Ion Channels and Channelopathies

Vyacheslav S. Korkosh
Anastasia K. Zaytseva
Anna A. Kostareva
Boris S. Zhorov

Frontiers in Pharmacology

doi 10.3389/fphar.2021.756415

4,635 views
6 citations

Brief Research Report

Published on 28 Oct 2021

Imprecision in Precision Medicine: Differential Response of a Disease-Linked GluN2A Mutant to NMDA Channel Blockers

in Pharmacology of Ion Channels and Channelopathies

Jenna R. Gale
Gabrielle J. Kosobucki
Karen A. Hartnett-Scott
Elias Aizenman

Frontiers in Pharmacology

doi 10.3389/fphar.2021.773455

4,184 views
5 citations

Original Research

Published on 21 Oct 2021

Block of Voltage-Gated Sodium Channels as a Potential Novel Anti-cancer Mechanism of TIC10

in Pharmacology of Ion Channels and Channelopathies

Eva Fuchs
David Alexander Christian Messerer
Georg Karpel-Massler
Michael Fauler
Thomas Zimmer
Bettina Jungwirth
Karl Josef Föhr

Frontiers in Pharmacology

doi 10.3389/fphar.2021.737637

3,434 views
5 citations

Original Research

Published on 18 Oct 2021

CRISPA: A Non-viral, Transient Cas9 Delivery System Based on Reengineered Anthrax Toxin

in Pharmacology of Ion Channels and Channelopathies

Maximilian Hirschenberger
Nicole Stadler
Maximilian Fellermann
Konstantin M. J. Sparrer
Frank Kirchhoff
Holger Barth
Panagiotis Papatheodorou

Frontiers in Pharmacology

doi 10.3389/fphar.2021.770283

6,269 views
11 citations

Original Research

Published on 14 Oct 2021

Possible Interactions of Extracellular Loop IVP2-S6 With Voltage-Sensing Domain III in Cardiac Sodium Channel

in Pharmacology of Ion Channels and Channelopathies

Anastasia K. Zaytseva
Aleksandr S. Boitsov
Anna A. Kostareva
Boris S. Zhorov

Frontiers in Pharmacology

doi 10.3389/fphar.2021.742508

2,755 views
7 citations

Opinion

Published on 04 Oct 2021

The Contribution of Dysfunctional Chloride Channels to Neurovascular Deficiency and Neurodegeneration

in Pharmacology of Ion Channels and Channelopathies

David A. Gascoigne
Alexander Drobyshevsky
Daniil P. Aksenov

Frontiers in Pharmacology

doi 10.3389/fphar.2021.754743

3,366 views
6 citations

Review

Published on 04 Oct 2021

New Challenges Resulting From the Loss of Function of Nav1.4 in Neuromuscular Diseases

in Pharmacology of Ion Channels and Channelopathies

Sophie Nicole
Philippe Lory

Frontiers in Pharmacology

doi 10.3389/fphar.2021.751095

9,005 views
11 citations

Original Research

Published on 30 Sep 2021

Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels

in Pharmacology of Ion Channels and Channelopathies

Frank S Choveau
Ismail Ben Soussia
Delphine Bichet
Chatelain C. Franck
Sylvain Feliciangeli
Florian Lesage

Frontiers in Pharmacology

doi 10.3389/fphar.2021.755826

2,859 views
5 citations

Original Research

Published on 29 Sep 2021

Optimization of Pichia pastoris Expression System for High-Level Production of Margatoxin

in Pharmacology of Ion Channels and Channelopathies

Muhammad Umair Naseem
Gabor Tajti
Attila Gaspar
Tibor G. Szanto
Jesús Borrego
Gyorgy Panyi

Frontiers in Pharmacology

doi 10.3389/fphar.2021.733610

17,543 views
14 citations

551 articles

articles

Mechanisms Underlying Gastrodin Alleviating Vincristine-Induced Peripheral Neuropathic Pain

Inhibition of the Nav1.7 Channel in the Trigeminal Ganglion Relieves Pulpitis Inflammatory Pain

Unique Pharmacological Properties of α-Conotoxin OmIA at α7 nAChRs

The Na+/Ca2+ Exchanger 3 Is Functionally Coupled With the NaV1.6 Voltage-Gated Channel and Promotes an Endoplasmic Reticulum Ca2+ Refilling in a Transgenic Model of Alzheimer’s Disease

Screening for Activity Against AMPA Receptors Among Anticonvulsants—Focus on Phenytoin

A Novel Spider Toxin Inhibits Fast Inactivation of the Nav1.9 Channel by Binding to Domain III and Domain IV Voltage Sensors

The L1624Q Variant in SCN1A Causes Familial Epilepsy Through a Mixed Gain and Loss of Channel Function

The Human SCN10AG1662S Point Mutation Established in Mice Impacts on Mechanical, Heat, and Cool Sensitivity

Toxic Peptide From Palythoa caribaeorum Acting on the TRPV1 Channel Prevents Pentylenetetrazol-Induced Epilepsy in Zebrafish Larvae

Synergistic Effect of Proteinase Activity by Purification and Identification of Toxic Protease From Nemopilema nomurai

Loss-of-Function Piezo1 Mutations Display Altered Stability Driven by Ubiquitination and Proteasomal Degradation

Molecular Pathology of Sodium Channel Beta-Subunit Variants

Corrigendum: Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels

Pathogenic in-Frame Variants in SCN8A: Expanding the Genetic Landscape of SCN8A-Associated Disease

Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression

Intersegment Contacts of Potentially Damaging Variants of Cardiac Sodium Channel

Imprecision in Precision Medicine: Differential Response of a Disease-Linked GluN2A Mutant to NMDA Channel Blockers

Block of Voltage-Gated Sodium Channels as a Potential Novel Anti-cancer Mechanism of TIC10

CRISPA: A Non-viral, Transient Cas9 Delivery System Based on Reengineered Anthrax Toxin

Possible Interactions of Extracellular Loop IVP2-S6 With Voltage-Sensing Domain III in Cardiac Sodium Channel

The Contribution of Dysfunctional Chloride Channels to Neurovascular Deficiency and Neurodegeneration

New Challenges Resulting From the Loss of Function of Nav1.4 in Neuromuscular Diseases

Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels

Optimization of Pichia pastoris Expression System for High-Level Production of Margatoxin