Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 01 Oct 2025

Drug-induced dermatomyositis: a pharmacovigilance study of the FDA adverse event reporting system

in Predictive Toxicology

Jianing Bi
Hanzhang Xie
Yixuan Yang
Qiaochu Chen
Bingnan Cui
Zhanshuo Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526836

516 views

Original Research

Published on 01 Oct 2025

Role of biomarker SOCS1 in peritoneal dialysis-associated peritoneal fibrosis and immune infiltration based on machine learning screening

in Predictive Toxicology

Xin Ma
Xiaona He
Yun Wang
Marcin Grzegorzek
Wenjie Long
Hongxi Chen
Fang Gao
Nan Mao
Xinyu Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1646948

1,314 views

Original Research

Accepted on 30 Sep 2025

Changes in cultivation parameters impact cytochrome P450 gene transcription in HepaRG cells: implications for in vitro toxicological assessments

in Predictive Toxicology

Kristina Jochum
Veronika Städele
Philip Marx-Stoelting

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1690384

Opinion

Published on 25 Sep 2025

Minocycline-induced DRESS: could dosage in relation to body fat mass be a contributing factor?

in Predictive Toxicology

Vincent Descamps

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681474

1,515 views

Case Report

Published on 24 Sep 2025

MRI imaging manifestations of severe toxic encephalopathy induced by excessive metoclopramide and multiple drug overdose: a case report

in Predictive Toxicology

Pengfei Liang
Yuncheng Tang
Xiaolin Zhang
Li Zhang
Juan Zhao
Haowen Tang
Zeyu Wu
Qiming Fang
Zhicheng Fang
Zhiwen Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683132

1,646 views

Original Research

Published on 17 Sep 2025

The role of α-hydroxybutyrate in modulating sepsis progression: identification of key targets and biomarkers through multi-database data mining, machine learning, and unsupervised clustering

in Predictive Toxicology

Qing Lu
Yujie Wu
Dayong Liao
Ying Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1615269

1,789 views

Editorial

Published on 16 Sep 2025

Editorial: Toxicity mechanisms, exposure, toxicokinetic and risk assessment aspects of metals, toxic for animals and humans, volume III

in Predictive Toxicology

Alex Boye
Yanzhu Zhu
Xinwei Li
Michel Mansur Machado
Fatma M. El Demerdash
Xu Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1690145

1,788 views

Review

Accepted on 10 Sep 2025

The Canonical Wnt Pathway in Osteoporosis: A Scoping Review of Key Compounds and Proteins Modulating Wnt-Induced Osteogenesis

in Predictive Toxicology

Nyruz Elahmer
Sok Kuan Wong
Nur Khadijah Muhamad Jamil
Isa Naina Mohamed
Sabarul Mokhtar
Norliza Muhammad

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669222

862 views

Correction

Published on 09 Sep 2025

Correction: Gastrointestinal stromal tumors with the use of ripretinib and sunitinib: real-world adverse event analysis based on the FDA adverse event reporting system (FAERS)

in Predictive Toxicology

Xinzhen Che
Yong Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1689499

1,296 views

Original Research

Published on 03 Sep 2025

Comprehensive safety assessment of Qiwei Tiexie Pill: integrating histopathological, biochemical, and metabolomic analyses in a rat model

in Predictive Toxicology

Qi Zheng
Wenya Liu
Cong Wang
Zhaoben Kan
Qian Wang
Lu Cui
Zhaoxiang Lin
Feng Zhou
Xin Feng
Junsong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567316

1,425 views

Case Report

Published on 02 Sep 2025

Successful rescue of a rare case of refractory shock due to multidrug toxicity: a case report

in Predictive Toxicology

Yuhua Xie
Yujie Zhou
Yunxing Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669831

1,166 views

Original Research

Published on 29 Aug 2025

Histopathological examination and transcriptomic profiling reveal gossypol toxicity-responsive genes related to fertility in mice

in Predictive Toxicology

Teame Gereziher Mehari
Maorong Jiang
Dandan Gu
Jiaxi Qian
Jungfeng Tang
Ashenafi Kiros Wubshet
Hui Fang
Kai Wang
Deng-Bing Yao
Baohua Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654299

1,076 views

Case Report

Published on 29 Aug 2025

Aortic dissection induced by licorice tablets overdose: a Case Report

in Predictive Toxicology

Xin Luo
Yuhan Wang
Bin Liu
Duyi Zhang
Yanfen Chai
Lijun Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610147

1,121 views

Original Research

Published on 26 Aug 2025

Risk factors for voriconazole-associated hepatotoxicity in patients with liver dysfunction: a retrospective nested case–control study

in Predictive Toxicology

Jing Ren
Xinfeng Cai
Wei Ge
Jinlin Guo
Shan Wang
Qinhui Wang
Linna Liu
Le Yang
Qi Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1625003

1,107 views

Case Report

Published on 25 Aug 2025

Case Report: A case of sudden death due to occupational nicotine poisoning: clinical presentation and MRI findings

in Predictive Toxicology

Jianjian Liu
Zhaozhao Shan
Xiangdong Jian
Baotian Kan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567380

1,276 views

Original Research

Published on 21 Aug 2025

Integrated neurobehavioral and organ-specific safety profiling of baicalin: acute/subacute toxicity studies

in Predictive Toxicology

Jiali Yang
Mengyu Chen
Wan Zhang
Jia Liu
Jing Zhao
Xin Ping
Ye Lu
Pei He
Lin Pei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1607919

1,070 views