Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 10 Nov 2021

Human Health Risk Assessment of Heavy Metals and Metalloids in Herbal Medicines Used to Treat Anxiety: Monitoring of Safety

in Predictive Toxicology

Ana C. R. Geronimo
Elaine S. P. Melo
Kassia R. N. Silva
Hugo S. Pereira
Valdir A. Nascimento
David J. Machate
Valter A. do Nascimento

Frontiers in Pharmacology

doi 10.3389/fphar.2021.772928

11,723 views
31 citations

Original Research

Published on 22 Oct 2021

CircEpc1 Promotes Ricin Toxin-Induced Inflammation via Activation of NF-κB and MAPK Signaling Pathways by Sponging miR-5114

in Predictive Toxicology

Mingxin Dong
Xiaohao Zhang
Haotian Yu
Yan Wang
Ying Chang
Chengbiao Sun
Jianxu Zhang
Na Zhao
Kaikai Yu
Guangchao Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2021.767900

3,056 views
6 citations

Original Research

Published on 18 Oct 2021

Evaluation of CML TKI Induced Cardiovascular Toxicity and Development of Potential Rescue Strategies in a Zebrafish Model

in Predictive Toxicology

Shan Cheng
Pan Jin
Heying Li
Duanqing Pei
Xiaodong Shu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.740529

7,181 views
10 citations

Original Research

Published on 14 Oct 2021

Path4Drug: Data Science Workflow for Identification of Tissue-Specific Biological Pathways Modulated by Toxic Drugs

in Predictive Toxicology

Barbara Füzi
Jana Gurinova
Henning Hermjakob
Gerhard F. Ecker
Rahuman Sheriff

Frontiers in Pharmacology

doi 10.3389/fphar.2021.708296

6,339 views
10 citations

Original Research

Published on 27 Sep 2021

Effects of Fluoride on Submandibular Glands of Mice: Changes in Oxidative Biochemistry, Proteomic Profile, and Genotoxicity

in Predictive Toxicology

Leidiane Alencar de Oliveira Lima
Giza Hellen Nonato Miranda
Walessa Alana Bragança Aragão
Leonardo Oliveira Bittencourt
Sávio Monteiro dos Santos
Michel Platini Caldas de Souza
Lygia S. Nogueira
Edivaldo Herculano Corrêa de Oliveira
Marta Chagas Monteiro
Aline Dionizio

Frontiers in Pharmacology

doi 10.3389/fphar.2021.715394

3,471 views
13 citations

Original Research

Published on 23 Sep 2021

Carbamazepine Induces Platelet Apoptosis and Thrombocytopenia Through Protein Kinase A

in Predictive Toxicology

Weiling Xiao
Kangxi Zhou
Mengnan Yang
Chenglin Sun
Lan Dai
Jian Gu
Rong Yan
Kesheng Dai

Frontiers in Pharmacology

doi 10.3389/fphar.2021.749930

9,708 views
14 citations

Original Research

Published on 21 Sep 2021

Effects of Bisphenols on RACK1 Expression and Their Immunological Implications in THP-1 Cells

in Predictive Toxicology

Erica Buoso
Maša Kenda
Mirco Masi
Pasquale Linciano
Valentina Galbiati
Marco Racchi
Marija Sollner Dolenc
Emanuela Corsini

Frontiers in Pharmacology

doi 10.3389/fphar.2021.743991

5,640 views
35 citations

Original Research

Published on 21 Sep 2021

Toxicity Evaluation of Long-Term Topical Application of Recombinant Human Keratinocyte Growth Factor-2 Eye Drops on Macaca Fascicularis

in Predictive Toxicology

Le Li
Lijia Li
Qi Chen
Xuanxin Yang
Qi Hui
Hamdi AL-Azzani
Yadong Huang
Jianqiu Cai
Xiaojie Wang
Zi Jin

Frontiers in Pharmacology

doi 10.3389/fphar.2021.740726

2,884 views

Original Research

Published on 16 Sep 2021

Lido-OH, a Hydroxyl Derivative of Lidocaine, Produced a Similar Local Anesthesia Profile as Lidocaine With Reduced Systemic Toxicities

in Predictive Toxicology

Qinqin Yin
Weiyi Zhang
Bowen Ke
Jin Liu
Wensheng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.678437

4,570 views
5 citations

Review

Published on 09 Sep 2021

Novel Methods and Approaches for Safety Evaluation of Nanoparticle Formulations: A Focus Towards In Vitro Models and Adverse Outcome Pathways

in Predictive Toxicology

Mounika Gayathri Tirumala
Pratibha Anchi
Susmitha Raja
Mahesh Rachamalla
Chandraiah Godugu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.612659

17,661 views
122 citations

Original Research

Published on 02 Sep 2021

Development, Testing, Parameterisation and Calibration of a Human PBPK Model for the Plasticiser, Di-(2-propylheptyl) Phthalate (DPHP) Using in Silico, in vitro and Human Biomonitoring Data

in Predictive Toxicology

Kevin McNally
Craig Sams
Alex Hogg
Annie Lumen
George Loizou

Frontiers in Pharmacology

doi 10.3389/fphar.2021.692442

5,826 views
9 citations

Original Research

Published on 01 Sep 2021

Spermine-Related DNA Hypermethylation and Elevated Expression of Genes for Collagen Formation are Susceptible Factors for Chemotherapy-Induced Hand-Foot Syndrome in Chinese Colorectal Cancer Patients

in Predictive Toxicology

Mingming Li
Jiani Chen
Shaoqun Liu
Xiaomeng Sun
Huilin Xu
Qianmin Gao
Xintao Chen
Chaowen Xi
Doudou Huang
Yi Deng

Frontiers in Pharmacology

doi 10.3389/fphar.2021.746910

6,192 views
13 citations

Original Research

Published on 26 Aug 2021

Mogroside V Alleviates Oocyte Meiotic Defects and Quality Deterioration in Benzo(a)pyrene-Exposed Mice

in Predictive Toxicology

Lumin Sui
Ke Yan
Huiting Zhang
Junyu Nie
Xiaogan Yang
Chang-Long Xu
Xingwei Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.722779

4,595 views
16 citations

Original Research

Published on 25 Aug 2021

Non-Lethal Concentration of MeHg Causes Marked Responses in the DNA Repair, Integrity, and Replication Pathways in the Exposed Human Salivary Gland Cell Line

in Predictive Toxicology

Lygia Sega Nogueira
Carolina P. Vasconcelos
Jessica Rodrigues Plaça
Geovanni Pereira Mitre
Leonardo Oliveira Bittencourt
Maria Sueli da Silva Kataoka
Edivaldo H. C. de Oliveira
Rafael Rodrigues Lima

Frontiers in Pharmacology

doi 10.3389/fphar.2021.698671

2,159 views

Original Research

Published on 23 Aug 2021

A Metabolic Profiling Study of Realgar-Induced Acute Kidney Injury in Mice

in Predictive Toxicology

Sheng Zhang
Chao Li
Tingting Feng
Shuai Cao
Heng Zhou
Limin Li
Qing Hu
Xiuhong Mao
Shen Ji

Frontiers in Pharmacology

doi 10.3389/fphar.2021.706249

3,756 views
14 citations

Original Research

Published on 19 Aug 2021

Dynamic Modeling of Mitochondrial Membrane Potential Upon Exposure to Mitochondrial Inhibitors

in Predictive Toxicology

Huan Yang
Wanda van der Stel
Randy Lee
Caroline Bauch
Sam Bevan
Paul Walker
Bob van de Water
Erik H. J. Danen
Joost B. Beltman

Frontiers in Pharmacology

doi 10.3389/fphar.2021.679407

8,657 views
22 citations

Review

Published on 13 Aug 2021

Toxicity of Immune-Checkpoint Inhibitors in Hematological Malignancies

in Predictive Toxicology

Katarina Hradska
Roman Hajek
Tomas Jelinek

Frontiers in Pharmacology

doi 10.3389/fphar.2021.733890

6,188 views
16 citations

Original Research

Published on 12 Aug 2021

Quantitative Structure-Activity Relationship Modeling of the Amplex Ultrared Assay to Predict Thyroperoxidase Inhibitory Activity

in Predictive Toxicology

Domenico Gadaleta
Luca d’Alessandro
Marco Marzo
Emilio Benfenati
Alessandra Roncaglioni

Frontiers in Pharmacology

doi 10.3389/fphar.2021.713037

4,030 views
10 citations

Original Research

Published on 10 Aug 2021

Swainsonine Triggers Paraptosis via ER Stress and MAPK Signaling Pathway in Rat Primary Renal Tubular Epithelial Cells

in Predictive Toxicology

Shuai Wang
Yazhou Guo
Chen Yang
Ruijie Huang
Yuting Wen
Chunyan Zhang
Chenchen Wu
Baoyu Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2021.715285

6,128 views
27 citations

Original Research

Published on 10 Aug 2021

Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat

in Predictive Toxicology

Sandra Concepcion Das
Kavitha Varadharajan
Muralitharan Shanmugakonar
Hamda A. Al-Naemi

Frontiers in Pharmacology

doi 10.3389/fphar.2021.663048

4,399 views
20 citations

Original Research

Published on 10 Aug 2021

Preclinical Pharmacokinetics, Tissue Distribution, and Primary Safety Evaluation of Indo5, a Novel Selective Inhibitor of c-Met and Trks

in Predictive Toxicology

Teng Luo
Fei-Xiang Zhang
Ke Zhao
Hui-Ying Gao
Shou-Guo Zhang
Lin Wang
Gui-Fang Dou
Ting Liu
Miao Yu
Yi-Qun Zhan

Frontiers in Pharmacology

doi 10.3389/fphar.2021.711126

3,826 views

Review

Published on 27 Jul 2021

Circular RNAs in the Regulation of Oxidative Stress

in Predictive Toxicology

Yao Zhang
Yu Chen
Yue Wan
Yueshui Zhao
Qinglian Wen
Xiaolong Tang
Jing Shen
Xu Wu
Mingxing Li
Xiang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2021.697903

6,087 views
31 citations

Original Research

Published on 22 Jul 2021

A Comparison of Nine Machine Learning Mutagenicity Models and Their Application for Predicting Pyrrolizidine Alkaloids

in Predictive Toxicology

Christoph Helma
Verena Schöning
Jürgen Drewe
Philipp Boss

Frontiers in Pharmacology

doi 10.3389/fphar.2021.708050

5,144 views
12 citations

Original Research

Published on 14 Jul 2021

Toxicological Assessment of Bromochlorophene: Single and Repeated-Dose 28-Day Oral Toxicity, Genotoxicity, and Dermal Application in Sprague–Dawley Rats

in Predictive Toxicology

Hansol Won
Da Hye Jeong
Hyo-Sook Shin
Jin Hee Lee
Jeong Pyo Lee
Jun-Young Yang
Kikyung Jung
Jayoung Jeong
Jae Ho Oh

Frontiers in Pharmacology

doi 10.3389/fphar.2021.690141

7,132 views
5 citations

490 articles

articles

Human Health Risk Assessment of Heavy Metals and Metalloids in Herbal Medicines Used to Treat Anxiety: Monitoring of Safety

CircEpc1 Promotes Ricin Toxin-Induced Inflammation via Activation of NF-κB and MAPK Signaling Pathways by Sponging miR-5114

Evaluation of CML TKI Induced Cardiovascular Toxicity and Development of Potential Rescue Strategies in a Zebrafish Model

Path4Drug: Data Science Workflow for Identification of Tissue-Specific Biological Pathways Modulated by Toxic Drugs

Effects of Fluoride on Submandibular Glands of Mice: Changes in Oxidative Biochemistry, Proteomic Profile, and Genotoxicity

Carbamazepine Induces Platelet Apoptosis and Thrombocytopenia Through Protein Kinase A

Effects of Bisphenols on RACK1 Expression and Their Immunological Implications in THP-1 Cells

Toxicity Evaluation of Long-Term Topical Application of Recombinant Human Keratinocyte Growth Factor-2 Eye Drops on Macaca Fascicularis

Lido-OH, a Hydroxyl Derivative of Lidocaine, Produced a Similar Local Anesthesia Profile as Lidocaine With Reduced Systemic Toxicities

Novel Methods and Approaches for Safety Evaluation of Nanoparticle Formulations: A Focus Towards In Vitro Models and Adverse Outcome Pathways

Development, Testing, Parameterisation and Calibration of a Human PBPK Model for the Plasticiser, Di-(2-propylheptyl) Phthalate (DPHP) Using in Silico, in vitro and Human Biomonitoring Data

Spermine-Related DNA Hypermethylation and Elevated Expression of Genes for Collagen Formation are Susceptible Factors for Chemotherapy-Induced Hand-Foot Syndrome in Chinese Colorectal Cancer Patients

Mogroside V Alleviates Oocyte Meiotic Defects and Quality Deterioration in Benzo(a)pyrene-Exposed Mice

Non-Lethal Concentration of MeHg Causes Marked Responses in the DNA Repair, Integrity, and Replication Pathways in the Exposed Human Salivary Gland Cell Line

A Metabolic Profiling Study of Realgar-Induced Acute Kidney Injury in Mice

Dynamic Modeling of Mitochondrial Membrane Potential Upon Exposure to Mitochondrial Inhibitors

Toxicity of Immune-Checkpoint Inhibitors in Hematological Malignancies

Quantitative Structure-Activity Relationship Modeling of the Amplex Ultrared Assay to Predict Thyroperoxidase Inhibitory Activity

Swainsonine Triggers Paraptosis via ER Stress and MAPK Signaling Pathway in Rat Primary Renal Tubular Epithelial Cells

Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat

Preclinical Pharmacokinetics, Tissue Distribution, and Primary Safety Evaluation of Indo5, a Novel Selective Inhibitor of c-Met and Trks

Circular RNAs in the Regulation of Oxidative Stress

A Comparison of Nine Machine Learning Mutagenicity Models and Their Application for Predicting Pyrrolizidine Alkaloids

Toxicological Assessment of Bromochlorophene: Single and Repeated-Dose 28-Day Oral Toxicity, Genotoxicity, and Dermal Application in Sprague–Dawley Rats