Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 14 Jun 2023

Human amnion-derived mesenchymal stem cells attenuate acute lung injury in two different acute lung injury mice models

in Predictive Toxicology

Yuxuan Wu
Hao Sun
Lianju Qin
Xiaomin Zhang
Hao Zhou
Yao Wang
Lumin Wang
Meng Li
Jiayin Liu
Jinsong Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1149659

3,151 views
4 citations

Original Research

Published on 07 Jun 2023

Cellular photo(geno)toxicity of gefitinib after biotransformation

in Predictive Toxicology

Meryem El Ouardi
Lorena Tamarit
Ignacio Vayá
Miguel A. Miranda
Inmaculada Andreu

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1208075

2,452 views
5 citations

Editorial

Published on 06 Jun 2023

Editorial: Advancements in computational studies of drug toxicity

in Predictive Toxicology

Noah R. Flynn
Grover P. Miller
S. Joshua Swamidass

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1230409

2,211 views
1 citation

Case Report

Published on 24 May 2023

Case report: Fatal poisoning caused by additive effects of two barbiturates

in Predictive Toxicology

Sella Takei
Hiroshi Kinoshita
Mostofa Jamal
Mitsuru Kumihashi
Tadayoshi Yamashita
Etsuko Tanaka
Sachiko Kawahara
Hiroko Abe
Kunihiko Tsutsui
Shoji Kimura

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1196565

9,360 views
3 citations

Original Research

Published on 23 May 2023

Toxicokinetics of recombinant human fibroblast growth factor 21 for injection in cynomolgus monkey for 3 months

in Predictive Toxicology

Chao Lu
Lei Jin
Jianing Bi
Hongyi Jin
Xinyi You
Lulu Peng
Haibing Fan
Huan Wang
Liangshun Wang
Zhengkai Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1176136

2,459 views

Correction

Published on 16 May 2023

Corrigendum: Dopamine homeostasis imbalance and dopamine receptors-mediated AC/cAMP/PKA pathway activation are involved in aconitine-induced neurological impairment in zebrafish and SH-SY5Y cells

in Predictive Toxicology

Jie Zhou
Cheng Peng
Qiuju Li
Xiaoyu Yan
Liang Yang
Mengting Li
Xiaoyu Cao
Xiaofang Xie
Dayi Chen
Chaolong Rao

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1219561

2,461 views
2 citations

Editorial

Published on 02 May 2023

Editorial: Model organisms in predictive toxicology 2022

in Predictive Toxicology

Yuhei Nishimura
Tetsuhiro Kudoh
Munekazu Komada

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1205945

2,105 views

Original Research

Published on 20 Apr 2023

Hurdles and signposts on the road to virtual control groups—A case study illustrating the influence of anesthesia protocols on electrolyte levels in rats

in Predictive Toxicology

A. Gurjanov
A. Kreuchwig
T. Steger-Hartmann
L. A. I. Vaas

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1142534

5,487 views
14 citations

Original Research

Published on 18 Apr 2023

Isoimperatorin therapeutic effect against aluminum induced neurotoxicity in albino mice

in Predictive Toxicology

Peramaiyan Rajendran
Duaa Althumairy
Mohammad Bani-Ismail
Gamal M. Bekhet
Emad A. Ahmed

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1103940

6,532 views
14 citations

Editorial

Published on 17 Apr 2023

Editorial: 3Rs—Strategies for reduction and refinement of animal studies

in Predictive Toxicology

Eleonore Fröhlich
George D. Loizou

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1200965

3,996 views
11 citations

Original Research

Published on 03 Apr 2023

Phytochemical component and toxicological evaluation of purple sweet potato leaf extract in male Sprague–Dawley rats

in Predictive Toxicology

Ahmad Safiyyu’d-din Bin Hisamuddin
Ruth Naomi
Khairul Aiman Bin Manan
Hasnah Bahari
Muhammad Dain Yazid
Fezah Othman
Hashim Embong
Siti Hadizah Jumidil
Mohd Khairi Hussain
Zainul Amiruddin Zakaria

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1132087

3,515 views
5 citations

Editorial

Published on 03 Apr 2023

Editorial: Case reports in predictive toxicology: 2022

in Predictive Toxicology

Eleonore Fröhlich
Dirk Steinritz

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1180949

2,264 views

Original Research

Published on 31 Mar 2023

Optimal experimental design for efficient toxicity testing in microphysiological systems: A bone marrow application

in Predictive Toxicology

Jonathan Cairns
Emilyanne Leonard
Kainat Khan
Conor Parks
Gareth Maglennon
Bairu Zhang
Stanley E. Lazic
Lorna Ewart
Rhiannon David

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1142581

7,640 views
11 citations

Original Research

Published on 23 Mar 2023

Multi-omics reveals hypertrophy of adipose tissue and lipid metabolism disorder via mitochondria in young mice under real-ambient exposure to air pollution

in Predictive Toxicology

Honglin Si
Tianlin Gao
Jing Yang
Jing Zhu
Ying Han
Chengwei Li
Jianxin Wang
Jianyu Li
Yanjie Zhao
Lei Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1122615

4,903 views
17 citations

Original Research

Published on 23 Mar 2023

Development, testing, parameterisation, and calibration of a human PBK model for the plasticiser, di (2-ethylhexyl) adipate (DEHA) using in silico, in vitro and human biomonitoring data

in Predictive Toxicology

Kevin McNally
Craig Sams
George Loizou

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1165770

3,098 views

Original Research

Published on 07 Mar 2023

Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro–in vivo extrapolation

in Predictive Toxicology

Engi Abdelhady Algharably
Emma Di Consiglio
Emanuela Testai
Francesca Pistollato
Anna Bal-Price
Abdulkarim Najjar
Reinhold Kreutz
Ursula Gundert-Remy

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1136174

4,731 views
14 citations

Original Research

Published on 02 Mar 2023

The role of chondrocyte-to-osteoblast trans-differentiation in fetal bone dysplasia of mice caused by prenatal exposure to dexamethasone

in Predictive Toxicology

Jiayong Zhu
Xiaoqi Zhao
Hui Wang
Hao Xiao
Liaobin Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1120041

2,891 views
6 citations

Original Research

Published on 02 Mar 2023

Molecular determinants of acrylamide neurotoxicity through covalent docking

in Predictive Toxicology

Nicolas Pierre Friedrich Mueller
Paolo Carloni
Mercedes Alfonso-Prieto

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1125871

6,683 views
8 citations

Original Research

Published on 02 Mar 2023

Physiologically based kinetic modeling of senecionine N-oxide in rats as a new approach methodology to define the effects of dose and endpoint used on relative potency values of pyrrolizidine alkaloid N-oxides

in Predictive Toxicology

Frances Widjaja
Liang Zheng
Sebastiaan Wesseling
Ivonne M. C. M. Rietjens

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1125146

3,127 views
10 citations

Original Research

Published on 22 Feb 2023

PBPK modeling to evaluate maximum tolerated doses: A case study with 3-chloroallyl alcohol

in Predictive Toxicology

Rory P. Conolly
Harvey J. Clewell
Martha M. Moore
Jerry L. Campbell
Wanyun Cheng
R. Robinan Gentry

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1088011

3,078 views
2 citations

Original Research

Published on 20 Feb 2023

Development, testing, parameterisation, and calibration of a human PBPK model for the plasticiser, di-(2-ethylhexyl) terephthalate (DEHTP) using in silico, in vitro and human biomonitoring data

in Predictive Toxicology

Kevin McNally
Craig Sams
Alex Hogg
George Loizou

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1140852

5,199 views
3 citations

Original Research

Published on 10 Feb 2023

Biosafety, histological alterations and residue depletion of feed administered anti-parasitic drug emamectin benzoate in golden mahseer, Tor putitora (Hamilton, 1822) as a model candidate fish for sport fishery and conservation in temperate waters

in Predictive Toxicology

Sumanta Kumar Mallik
Shivam Singh
Neetu Shahi
Prasanna Kumar Patil
Krishna Kala
Richa Pathak
Abhay Kumar Giri
Partha Das
Ritesh Shantilal Tandel
Suresh Chandra

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1106124

4,777 views
9 citations

Original Research

Published on 08 Feb 2023

Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions

in Predictive Toxicology

Thi-Phuong Tao
Ilka Maschmeyer
Edward L. LeCluyse
Eda Rogers
Katrin Brandmair
Silke Gerlach
Julia Przibilla
Fredy Kern
Camille Genies
Carine Jacques

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1076254

6,701 views
17 citations

Editorial

Published on 06 Feb 2023

Editorial: Toxicity mechanism and clinical features of PD-1/PD-l1 inhibitors in treatment of cancer, volume II

in Predictive Toxicology

Chuqi Lei
Xiangyi Kong
Ryan J. Sullivan
Caisheng Wu
Dawei Wang
Lin Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1136373

2,181 views

490 articles

articles

Human amnion-derived mesenchymal stem cells attenuate acute lung injury in two different acute lung injury mice models

Cellular photo(geno)toxicity of gefitinib after biotransformation

Editorial: Advancements in computational studies of drug toxicity

Case report: Fatal poisoning caused by additive effects of two barbiturates

Toxicokinetics of recombinant human fibroblast growth factor 21 for injection in cynomolgus monkey for 3 months

Corrigendum: Dopamine homeostasis imbalance and dopamine receptors-mediated AC/cAMP/PKA pathway activation are involved in aconitine-induced neurological impairment in zebrafish and SH-SY5Y cells

Editorial: Model organisms in predictive toxicology 2022

Hurdles and signposts on the road to virtual control groups—A case study illustrating the influence of anesthesia protocols on electrolyte levels in rats

Isoimperatorin therapeutic effect against aluminum induced neurotoxicity in albino mice

Editorial: 3Rs—Strategies for reduction and refinement of animal studies

Phytochemical component and toxicological evaluation of purple sweet potato leaf extract in male Sprague–Dawley rats

Editorial: Case reports in predictive toxicology: 2022

Optimal experimental design for efficient toxicity testing in microphysiological systems: A bone marrow application

Multi-omics reveals hypertrophy of adipose tissue and lipid metabolism disorder via mitochondria in young mice under real-ambient exposure to air pollution

Development, testing, parameterisation, and calibration of a human PBK model for the plasticiser, di (2-ethylhexyl) adipate (DEHA) using in silico, in vitro and human biomonitoring data

Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro–in vivo extrapolation

The role of chondrocyte-to-osteoblast trans-differentiation in fetal bone dysplasia of mice caused by prenatal exposure to dexamethasone

Molecular determinants of acrylamide neurotoxicity through covalent docking

Physiologically based kinetic modeling of senecionine N-oxide in rats as a new approach methodology to define the effects of dose and endpoint used on relative potency values of pyrrolizidine alkaloid N-oxides

PBPK modeling to evaluate maximum tolerated doses: A case study with 3-chloroallyl alcohol

Development, testing, parameterisation, and calibration of a human PBPK model for the plasticiser, di-(2-ethylhexyl) terephthalate (DEHTP) using in silico, in vitro and human biomonitoring data

Biosafety, histological alterations and residue depletion of feed administered anti-parasitic drug emamectin benzoate in golden mahseer, Tor putitora (Hamilton, 1822) as a model candidate fish for sport fishery and conservation in temperate waters

Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions

Editorial: Toxicity mechanism and clinical features of PD-1/PD-l1 inhibitors in treatment of cancer, volume II