Frontiers in Pharmacology | Translational Pharmacology

Original Research

Published on 02 Apr 2025

Male mice treated with combined anti-fibrotic therapeutics, IPW5371 and tadalafil, are predisposed to adverse cardiovascular events

in Translational Pharmacology

Jazz Q. Stephens
Uriel Blas-Machado
Chrissy Sherrill
David Caudell
Nancy Kock
Ashley M. Davis
Jordyn M. Whitfield
Barry Hart
Kylie Kavanagh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537494

143 views

Review

Accepted on 31 Mar 2025

Advances in Biomaterials for Osteonecrosis Treatment

in Translational Pharmacology

Dapeng Wang
Jiannan Li
Yu Liu
Shuaishuai Wang
Shuo Duan
Zhiyang Liu
Shuaiwei Li
Guangwei Meng
Zhang Minglei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559810

Review

Accepted on 31 Mar 2025

Metformin in gynecological disorders: pathogenic insights and therapeutic implications

in Translational Pharmacology

Ping Nie
Minghua Wang
Yan Mo
Hong Zhou
Qingbing Zha
Gendie E Lash
Ping Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526709

Original Research

Published on 31 Mar 2025

Anti-CTLA-and anti-PD-1 immune checkpoint inhibitor antibodies impair human sperm motility in-vitro

in Translational Pharmacology

Ilaria Cosci
Luca De Toni
Paolo Del Fiore
Andrea Di Nisio
Samuela Carraro
Claudia Maria Radu
Loris Bertazza
Simone Mocellin
Jacopo Pigozzo
Giovanna Crivellaro

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534975

280 views

Original Research

Accepted on 28 Mar 2025

Unveiling p65 as the target of diphyllin in ameliorating metabolic dysfunction-associated steatotic liver disease via targeted protein degradation technology

in Translational Pharmacology

Xuejing Zhu
Lei Zhang
Wenqian Cui
Liangjie Wang
Fengjing Xu
Mengyuan Liu
Shuangcheng Chen
Haowen Jiang
Zhiying He
Chang Peng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567639

Original Research

Published on 27 Mar 2025

Comparative efficacy of Pirfenidone and Meloxicam on early radiotherapy-induced anal sphincter dysfunction in rats

in Translational Pharmacology

Dragoș Viorel Scripcariu
Cezar Cătălin Caratașu
Mitică Ciorpac
Teodora Alexa-Stratulat
Andrei Szilagyi
Cristian Răzvan Buga
Bogdan Ionuţ Dobrovăț
Lucian Eva
Andrei Daniel Timofte
Ludmila Lozneanu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1441011

404 views

Original Research

Published on 26 Mar 2025

Metformin attenuates diabetic osteoporosis by suppressing ferroptosis via the AMPK/Nrf2 pathway

in Translational Pharmacology

Yanwei Liu
Zhaoyu Fu
Xinyu Wang
Qifan Yang
Shun Liu
Dong Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1527316

232 views

Clinical Trial

Published on 26 Mar 2025

A phase I study to evaluate the safety, tolerability, and pharmacokinetics of HEC113995PA·H2O, a novel dual-acting serotonergic antidepressant, in healthy subjects

in Translational Pharmacology

Xue Wu
Qingqing Wu
Qichen Ding
Yulei Zhuang
Lin Luo
Yingjun Zhang
Li Deng
Chuanfei Jin
Xue Li
Zhangma Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1500974

225 views

Original Research

Published on 25 Mar 2025

Potential effects of lipid lowering and antioxidant activity of exosomes from Phascolosoma esculenta: in vivo and in vitro studies

in Translational Pharmacology

Lin Yang
Xue Yi
Meitao Duan
Ahmed Mahal
Binbin Chen
Zhiqiang Zhang
Jungang Ren
Ming Chen
Chen Meng
Moxun Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560462

344 views

Original Research

Accepted on 24 Mar 2025

Tacrolimus exposure during the three-month period following allogeneic stem cell transplantation predicts overall survival

in Translational Pharmacology

Alzbeta Zavrelova
Katerina Zibridova
Jakub Radocha
Eva Cermakova
Petra Rozsivalova
Pavel Zak
Benjamin Visek
Miriam Lanska
Jana Stevkova
Sara Merdita

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1517083

Original Research

Accepted on 21 Mar 2025

The ultrafine powder of atractylodis macrocephalae rhizoma improves immune function in naturally aging rats by regulating the PI3K/Akt/NF-κB signaling pathway

in Translational Pharmacology

Yu Wang
Su Jie
Su Gao
Zhuangwei Niu
Yiqin Zhou
Suhong Chen
Guiyuan Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550357

Clinical Trial

Published on 21 Mar 2025

The effect of high-fat diet on the pharmacokinetics of ondansetron hydrochloride tablets in healthy Chinese subjects

in Translational Pharmacology

Na Zhao
Caiyun Jia
Yiting Hu
Xue Sun
Haojing Song
Bo Qiu
Wanjun Bai
Zhanjun Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1512857

222 views

Original Research

Published on 20 Mar 2025

Metformin inhibits pathological retinal neovascularization but promotes retinal fibrosis in experimental neovascular age-related macular degeneration

in Translational Pharmacology

Xin Wang
Xu Liang
Shiya Huang
Mingyan Wei
Yuan Xu
Xiaodong Chen
Yanliang Miao
Rongrong Zong
Xiang Lin
Shiying Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547492

354 views

Original Research

Accepted on 19 Mar 2025

Carnosine Alleviates Oxidative Stress to Prevent Cellular Senescence by Regulating Nrf2/HO-1 Pathway: A Promising Anti-Aging Strategy for Oral Mucosa

in Translational Pharmacology

Haoan He
Chao Lv
Yuhong Xie
Wei Li
Zihang Ling
Bin Cheng
Xiaoan Tao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559584

Clinical Trial

Published on 19 Mar 2025

The adjunctive role of metformin in patients with mild to moderate ulcerative colitis: a randomized controlled study

in Translational Pharmacology

Ammena Y. Binsaleh
Sahar M. El-Haggar
Sahar K. Hegazy
Maha M. Maher
Monir M. Bahgat
Thanaa A. Elmasry
Sarah Alrubia
Amsha S. Alsegiani
Mamdouh Eldesoqui
Mostafa M. Bahaa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1507009

458 views

Original Research

Published on 19 Mar 2025

Metformin as a disease-modifying therapy in osteoarthritis: bridging metabolism and joint health

in Translational Pharmacology

Iryna Halabitska
Pavlo Petakh
Oleksandr Kamyshnyi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567544

239 views