Frontiers in Pharmacology | Translational Pharmacology

Original Research

Accepted on 13 Mar 2025

HPLC-UV method development and validation for anticancer drug sorafenib and the co-prescribed drug dexamethasone: Application to pharmacokinetic evaluation of sorafenib nanoformulations HPLC-UV method development and validation for anticancer drug sorafenib and co-prescribed drugs: Application to pharmacokinetic evaluation of sorafenib nanoformulations

in Translational Pharmacology

Abdul Mateen
Abad Khan
Ismail Khan
Saifullah Khan Khalil
Lateef Ahmad
Muhammad Junaid
Saqib Jehan
Muhammad Sohail Anwar
Muhammad Faheem
Abdul Salam

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1442762

Clinical Trial

Accepted on 06 Mar 2025

A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HEC113995PA•H2O, a Novel Dual-acting Serotonergic Antidepressant, in Healthy Subjects

in Translational Pharmacology

XUE WU
Qingqing Wu
Qichen Ding
Yulei Zhuang
Lin Luo
Yingjun Zhang
Li Deng
Chuanfei Jin
Xue Li
Zhangma Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1500974

Original Research

Published on 05 Mar 2025

Sodium nitrate regulates senescence accompanied by aortic atherosclerosis in ApoE−/− mice through the miR-34a/FGF-21 axis

in Translational Pharmacology

Ning Tao
Zhichao He
Han Duan
Liang Wang
Jing Yi
Jingyuan Shao
Lin Lv
Junzhao Duan
Hu Cao
Xiwen Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562321

169 views

Clinical Trial

Accepted on 04 Mar 2025

The Effect of High-Fat Diet on the Pharmacokinetics of Ondansetron Hydrochloride Tablets in Healthy Chinese Subjects

in Translational Pharmacology

Na Zhao
Caiyun Jia
Yiting Hu
Xue Sun
Haojin Song
Bo Qiu
Wanjun Bai
Zhanjun Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1512857

Editorial

Accepted on 03 Mar 2025

Editorial: The potential of transferrin as a drug target and delivery molecule

in Translational Pharmacology

Patricia Carrilho
Sidharth Chopra
Mallikarjuna Rao Pichika
Robert Fleming
Nermi Parrow

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584190

Brief Research Report

Published on 03 Mar 2025

SysNatMed: rational natural medicine discovery by systems genetics

in Translational Pharmacology

Chang-Qing Ye
Jie Leng
Meng-Yuan Jin
Yuan-Dong Meng
Zi-Yi Zhao
Fan-Xing Meng
Xuan Xu
Sha-Sha Fan
Hong-Bin Luo
Xiang-Yu Meng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1496061

242 views

Original Research

Accepted on 27 Feb 2025

Metformin as a Disease-Modifying Therapy in Osteoarthritis: Bridging Metabolism and Joint Health

in Translational Pharmacology

Iryna Halabitska
Pavlo Petakh
Oleksandr Kamyshnyi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567544

Review

Accepted on 27 Feb 2025

Functional tumor-derived exosomes in NSCLC progression and clinical implications

in Translational Pharmacology

Yuxin Gao
Jun Xie
Zhenya Yang
Mengxi Li
Hongfan Yuan
Rui Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1485661

Original Research

Accepted on 27 Feb 2025

Comparative efficacy of Pirfenidone and Meloxicam on early radiotherapy-induced anal sphincter dysfunction in rats

in Translational Pharmacology

Dragos Viorel Scripcariu
Cezar Catalin Caratasu
Mitica Ciorpac
Teodora Alexa-Stratulat
Andrei Szilagyi
Cristian Razvan Buga
Bogdan Ionut Dobrovat
Lucian Eva
Ludmila Lozneanu
Irina Draga Caruntu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1441011

100 views

Original Research

Published on 26 Feb 2025

Knowledge structure and dynamic evolution of nanomedicine in liver cancer research: a scientometric analysis and visualization

in Translational Pharmacology

Shaodong Li
Dapeng Cui
Bo Shao
Zhenhua Kang
Guoqiang Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1509259

244 views

Review

Published on 26 Feb 2025

Muscle loss in cancer cachexia: what is the basis for nutritional support?

in Translational Pharmacology

Jaline Faiad
Márcia Fábia Andrade
Gabriela de Castro
Joyce de Resende
Marina Coêlho
Giovana Aquino
Marilia Seelaender

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1519278

323 views

Original Research

Accepted on 24 Feb 2025

Metformin Inhibits Retinal Neovascularization but Promotes Retinal Fibrosis on Experimental Neovascular Age-related Macular Degeneration

in Translational Pharmacology

Qian Chen
Xin Wang
Xu Liang
Shiya Huang
Mingyan Wei
Xu Yuan
Xiaodong Chen
Yanliang Miao
Rongrong Zong
Xiang Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547492

Original Research

Accepted on 17 Feb 2025

Male Mice Treated with Combined Anti-Fibrotic Therapeutics, IPW5371 and Tadalafil, are Predisposed to Adverse Cardiovascular Events

in Translational Pharmacology

Jazz Stephens
Uriel Blas-Machado
Chrissy Sherrill
David Caudell
Nancy Kock
Ashley Davis
Jordyn Whitfield
Barry Hart
Kylie Kavanagh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537494

Original Research

Published on 17 Feb 2025

A double-layer PLGA/CoI-MeHA tissue engineering scaffold for urethral reconstruction

in Translational Pharmacology

Mingyang Chang
Qinyuan Tan
Ge Bian
Ming Zhang
Jianing Lv
Junjie Su
Xiaoqing Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1555183

356 views

Clinical Trial

Accepted on 14 Feb 2025

The Adjunctive Role of Metformin in Patients with Mild to Moderate Ulcerative Colitis: A Randomized Controlled Study

in Translational Pharmacology

Mostafa Bahaa
Ammena Y Binsaleh
Sahar M El-Haggar
Sahar K Hegazy
Maha M Maher
Monir M Bahgat
Thanaa A Elmasry
Sarah Alrubia
Amsha S Alsegiani
Mamdouh Eldesouqui

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1507009

114 views

Review

Published on 13 Feb 2025

Exploring the application of metal-based photothermal agents in photothermal therapy combined with immune checkpoint therapy

in Translational Pharmacology

Bin Xie
ZhiRong Xiao
JiaBao Ling
Yichao Peng
Tianfeng Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1553158

434 views

Navigation group

Articles

A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HEC113995PA•H2O, a Novel Dual-acting Serotonergic Antidepressant, in Healthy Subjects

Sodium nitrate regulates senescence accompanied by aortic atherosclerosis in ApoE−/− mice through the miR-34a/FGF-21 axis

The Effect of High-Fat Diet on the Pharmacokinetics of Ondansetron Hydrochloride Tablets in Healthy Chinese Subjects

Editorial: The potential of transferrin as a drug target and delivery molecule

SysNatMed: rational natural medicine discovery by systems genetics

Metformin as a Disease-Modifying Therapy in Osteoarthritis: Bridging Metabolism and Joint Health

Functional tumor-derived exosomes in NSCLC progression and clinical implications

Comparative efficacy of Pirfenidone and Meloxicam on early radiotherapy-induced anal sphincter dysfunction in rats

Knowledge structure and dynamic evolution of nanomedicine in liver cancer research: a scientometric analysis and visualization

Muscle loss in cancer cachexia: what is the basis for nutritional support?

Metformin Inhibits Retinal Neovascularization but Promotes Retinal Fibrosis on Experimental Neovascular Age-related Macular Degeneration

Male Mice Treated with Combined Anti-Fibrotic Therapeutics, IPW5371 and Tadalafil, are Predisposed to Adverse Cardiovascular Events

A double-layer PLGA/CoI-MeHA tissue engineering scaffold for urethral reconstruction

The Adjunctive Role of Metformin in Patients with Mild to Moderate Ulcerative Colitis: A Randomized Controlled Study

Exploring the application of metal-based photothermal agents in photothermal therapy combined with immune checkpoint therapy