Frontiers in Pharmacology | Translational Pharmacology

Original Research

Published on 12 Aug 2025

A case–control study on the individualized use of opioid analgesics based on single-nucleotide polymorphism

in Translational Pharmacology

Jing Yang
Lei Zheng
Fu Zheng
Shu-Han Zhou
Liang-Wei Sun
Chao Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1629866

1,531 views

Review

Published on 11 Aug 2025

From neuromodulation to bone homeostasis: therapeutic targets of nerve growth factor in skeletal diseases

in Translational Pharmacology

Kaixuan Chen
Longjun Chen
Yizhong Ma
Siqi Chen
Jinze Liu
Hangyu Zhou
Yuzhu Chen
Guanyi Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1614542

2,705 views
2 citations

Original Research

Published on 01 Aug 2025

Healthy participant engagement in early clinical trials: results from the European EUFEMED survey

in Translational Pharmacology

J. Klein
T. van Iersel
D. de Vries
Y. Donazzolo
I. Klingmann

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1540948

1,538 views

Original Research

Published on 31 Jul 2025

Ultrasound combined with microbubble enhanced renoprotective effects of NLRP3 inflammasome inhibitor MCC950 in CKD model

in Translational Pharmacology

Wen Wen
Bin Tu
Xiaomei Ren
Yangli Liu
Rufang Jiang
Xiaofeng Wu
Jian Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1616542

1,598 views

Original Research

Published on 30 Jul 2025

Hydroxyethyl starch-curcumin nanoparticles ameliorate DSS-induced ulcerative colitis in mice via synergistic TLR4/NF-κB suppression, Nrf2 activation, intestinal barrier restoration, and gut microbiota modulation

in Translational Pharmacology

Sheng Li
Shiyi Lu
Jiahui Xiong
Liang Chen
Yanting Lin
Xiaohui Chen
Xinyi Wang
Lijing Lin
Xiaoliang Cai
Xiaoyu Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610711

3,249 views
1 citation

Original Research

Published on 29 Jul 2025

Cadonilimab in combination with chemotherapy for HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma: a cost-effectiveness analysis

in Translational Pharmacology

Zuojuan Xiang
Wei Li
Qiao Xia

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1646818

2,484 views

Review

Published on 28 Jul 2025

Hydrogel technologies in andrology: advances in research and prospective applications

in Translational Pharmacology

Xinlei Guo
Jingyi Zhang
Yanxin Guan
Xingzhao Tian
Yanan Gong
Yao Xiao
Fang Yang
Degui Chang
Xujun Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1635007

4,152 views

Original Research

Published on 23 Jul 2025

Machine learning analysis of ARVC informed by sodium channel protein-based interactome networks

in Translational Pharmacology

Yanan Zhu
Hui Zhang
Xuan Zhao
Xin Wang
Lina Xing
Sijie Yao
Xiao Jin
Tingting Li
Ting Dai
Xinyue Ding

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1611342

2,306 views

Original Research

Published on 17 Jul 2025

Assessment of drug permeability using a small airway microphysiological system

in Translational Pharmacology

Robert M. Geiger
Shekh M. Rahman
Md Shadiqur Rashid Roni
Catherine Sullenberger
Sabyasachy Mistry
Katherine Shea
Isra Tariq
Omnia A. Ismaiel
Murali K. Matta
Paula L. Hyland

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621775

4,721 views

Clinical Trial

Published on 16 Jul 2025

Efficacy of using pentoxifylline in patients undergoing breast cancer surgery

in Translational Pharmacology

Samar A. Dewidar
Noha O. Mansour
Omar Hamdy
Dina A. Elebedy
Moetaza M. Soliman
Mohamed E. E. Shams

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560805

2,287 views
1 citation

Review

Published on 15 Jul 2025

Ferroptosis: a novel pharmacological mechanism against multiple myeloma

in Translational Pharmacology

Jingbo Shi
Yitong Lu
Wenjian Wei
Guodong Ma
Changnian Li
Lulu Li
Yaru Wang
Yan Wang
Ruirong Xu
Siyuan Cui

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1606804

4,703 views
5 citations

Review

Published on 14 Jul 2025

Functional nanomaterials for enhanced tumor photothermal therapy - the mechanisms and applications

in Translational Pharmacology

Xiaoling Han
Guohai Feng
Xiaoman Li
Shuyi Mo
Caijing Xu
Jiahui Yan
Li Yu
Rong Zhang
Ying Jin
Xiao Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1604965

3,716 views
4 citations

Review

Published on 03 Jul 2025

Potential value and cardiovascular risks of programmed cell death in cancer treatment

in Translational Pharmacology

Tian Yue
Dezhi Zheng
Jiali Yang
Jian He
Jun Hou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1615974

2,793 views
3 citations

Original Research

Published on 27 Jun 2025

Simplified flow cytometry-based assay for rapid multi-cytokine profiling and machine-learning-assisted diagnosis of inflammatory diseases

in Translational Pharmacology

Qiang Quan
Xuegui Ju
Guangmei Li
Lu Ye
Sichong Ren
Shuxin Yang
Rui Zhang
Hui Wang
Ruyue Lin
Luoting Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1594141

2,490 views

Review

Published on 20 Jun 2025

Research progress on endoplasmic reticulum homeostasis in acute kidney injury

in Translational Pharmacology

Liling Hu
Huike Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1595845

2,095 views

Original Research

Published on 19 Jun 2025

Unveiling therapeutic targets and preventive components for kidney insufficiency and blood stasis-type BPH: bridging metabolomics, network pharmacology and reverse screening

in Translational Pharmacology

Xiangpeng Kong
Haiqin Ren
Ke Pei
Yajun Yao
Zhigang Liang
Yunfeng Xue
Shuang Liang
Tongtong Li
Jing Zhang
Yuxia Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584766

3,107 views
1 citation

Review

Published on 18 Jun 2025

Stem cells in the treatment of myocardial injury-induced cardiomyopathy: mechanisms and efficient utilization strategies

in Translational Pharmacology

Jiali Yang
Tian Yue
Jian He
Shiqiang Xiong
Yan Luo
Jun Hou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1600604

2,179 views
2 citations

Review

Published on 13 Jun 2025

Advances and challenges in cancer immunotherapy: mechanisms, clinical applications, and future directions

in Translational Pharmacology

Neeharika Vatsavai
Sumeet Kaur Bhinder
Rahaman Shaik
Shaheen Mahira
Shruti Kapoor
Md Shadab Ali
Deepak Verma
Jay Singh
Sreelakshmi Badavenkatappa Gari
Prabhat Upadhyay

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1602529

7,876 views
5 citations

Case Report

Published on 12 Jun 2025

Unexpected voriconazole toxicity due to nirmatrelvir/ritonavir: a case report on drug-drug interaction and the role of therapeutic drug monitoring

in Translational Pharmacology

J. López-Hernández
A. B. Guisado-Gil
M. Mejías-Trueba
L. Herrera-Hidalgo
F. J. Reina-Martínez
M. V. Gil-Navarro

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1616061

2,425 views
3 citations

Original Research

Published on 02 Jun 2025

Improving drug-drug interaction prediction via in-context learning and judging with large language models

in Translational Pharmacology

He Qi
Xiaoqiang Li
Chengcheng Zhang
Tianyi Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1589788

4,912 views
6 citations

Original Research

Published on 30 May 2025

Harnessing dual variational autoencoders to decode microbe roles in diseases for traditional medicine discovery

in Translational Pharmacology

Qing Ye
Yaxin Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578140

1,231 views
1 citation

Original Research

Published on 30 May 2025

Zabedosertib, a novel interleukin-1 receptor-associated kinase-4 inhibitor, shows a favorable pharmacokinetic and safety profile across multiple phase 1 studies

in Translational Pharmacology

Maximilian Feldmüller
Stefan J. Jodl
Bart Ploeger
Andrea Wagenfeld
Herbert Wiesinger
Frank S. Zollmann
Stefan Klein
Ruiping Zhang
Beate Rohde
Joachim Höchel

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1521505

3,295 views
2 citations

Original Research

Published on 30 May 2025

Functionalized turmeric nanovesicles for precision delivery of doxorubicin in colorectal carcinoma treatment

in Translational Pharmacology

Chen Meng
Xue Yi
Meitao Duan
Ahmed Mahal
Zhiqiang Zhang
Jungang Ren
Ming Chen
Lin Yang
Moxun Xu
Ahmad J. Obaidullah

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1587560

2,401 views

Mini Review

Published on 30 May 2025

GLP-1R in diabetes mellitus: from basic discovery to therapeutics development

in Translational Pharmacology

Shujun Li
Nanqu Huang
Mei Wang
Wendi Huang
Yong Luo
Juan Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610512

6,063 views
9 citations