Frontiers in Pharmacology | Translational Pharmacology

Original Research

Published on 22 May 2025

Glucagon-like peptide-1, fibroblast growth factor 21, and other endocrine responses to alcohol ingestion in women before and after metabolic surgery

in Translational Pharmacology

Mariel Molina-Castro
Blair Rowitz
Marta Yanina Pepino

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575156

3,323 views
1 citation

Review

Published on 21 May 2025

Advances in biomaterials for osteonecrosis treatment

in Translational Pharmacology

Dapeng Wang
Jiannan Li
Yu Liu
Shuaishuai Wang
Shuo Duan
Zhiyang Liu
Shuaiwei Li
Jun Liang
Guangwei Meng
Minglei Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559810

2,758 views

Original Research

Published on 14 May 2025

A novel adenosine-to-inosine RNA editing-based nomogram for predicting prognosis of hepatocellular carcinoma

in Translational Pharmacology

Shiqiong Huang
Ji Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547320

1,585 views

Review

Published on 14 May 2025

BCAA metabolism in cancer progression and therapy resistance: The balance between fuel and cell signaling

in Translational Pharmacology

Yi Zhou
Jiahui Kou
Wenjin Li
Yuyao Wang
Xingxing Su
Hongguang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1595176

6,166 views
2 citations

Mini Review

Published on 13 May 2025

Metabolite 2-aminoadipic acid: implications for metabolic disorders and therapeutic opportunities

in Translational Pharmacology

Weiyan Shi
Zhiqiang Yang
Pengbin Fu
Yang Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569020

3,984 views
4 citations

Clinical Trial

Published on 02 May 2025

Randomized, double-blind, placebo-controlled pilot study of metformin as an adjunctive therapy in Parkinson’s disease

in Translational Pharmacology

Hayam Ali AlRasheed
Mostafa M. Bahaa
Thanaa A. Elmasry
Eman I. Elberri
Fedaa A. Kotkata
Ramy M. El Sabaa
Yasmine M. Elmorsi
Mostafa M. Kamel
Walaa A. Negm
Amir O. Hamouda

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1497261

6,075 views
4 citations

Original Research

Published on 28 Apr 2025

Unveiling p65 as the target of diphyllin in ameliorating metabolic dysfunction-associated steatotic liver disease via targeted protein degradation technology

in Translational Pharmacology

Xuejing Zhu
Lei Zhang
Wenqian Cui
Liangjie Wang
Fengjing Xu
Mengyuan Liu
Shuangcheng Chen
Haowen Jiang
Zhiying He
Chang Peng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567639

3,111 views
4 citations

Original Research

Published on 25 Apr 2025

Tacrolimus exposure during the three-month period following allogeneic stem cell transplantation predicts overall survival

in Translational Pharmacology

Alzbeta Zavrelova
Katerina Zibridova
Jakub Radocha
Eva Cermakova
Petra Rozsivalova
Pavel Zak
Benjamin Visek
Miriam Lanska
Jana Stevkova
Sara Merdita

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1517083

1,930 views

Review

Published on 22 Apr 2025

Metformin in gynecological disorders: pathogenic insights and therapeutic implications

in Translational Pharmacology

Ping Nie
Minghua Wang
Yan Mo
Hong Zhou
Qingbing Zha
Gendie E. Lash
Ping Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526709

8,073 views
6 citations

Original Research

Published on 14 Apr 2025

Development of an adipocyte differentiation protocol using 3T3-L1 cells for the investigation of the browning process: identification of the PPAR-γ agonist rosiglitazone as a browning reference drug

in Translational Pharmacology

Lorenzo Flori
Giulia Galgani
Giorgia Bray
Chiara Ippolito
Cristina Segnani
Carolina Pellegrini
Valentina Citi
Nunzia Bernardini
Alma Martelli
Vincenzo Calderone

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546456

7,913 views
5 citations

Original Research

Published on 11 Apr 2025

Ultrasensitive RNase H activity detection using the transcription-based hybrid probe and CRISPR/cas12a signal amplifier

in Translational Pharmacology

Sheng Ding
Yinghua Wei
Minglong Yang
Jinyi Shi
Kaiyuan Ren
Xinli Li
Zhuo Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1589150

2,306 views

Original Research

Published on 10 Apr 2025

Carnosine alleviates oxidative stress to prevent cellular senescence by regulating Nrf2/HO-1 pathway: a promising anti-aging strategy for oral mucosa

in Translational Pharmacology

Haoan He
Chao Lv
Yuhong Xie
Wei Li
Zihang Ling
Bin Cheng
Xiaoan Tao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559584

5,248 views
5 citations

Original Research

Published on 09 Apr 2025

HPLC-UV method development and validation for anticancer drug sorafenib and the co-prescribed drug dexamethasone: application to pharmacokinetic evaluation of sorafenib nanoformulations

in Translational Pharmacology

Abdul Mateen
Abad Khan
Ismail Khan
Saifullah Khan Khalil
Lateef Ahmad
Muhammad Junaid
Saqib Jehan
Muhammad Sohail Anwar
Muhammad Faheem
Abdul Salam

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1442762

2,788 views
2 citations

Systematic Review

Published on 04 Apr 2025

The efficacy of different doses of citicoline in improving the prognosis of patients with acute ischemic stroke based on network meta-analysis

in Translational Pharmacology

Xu Zhao
Xianhao Huo
Yizhen Meng
Ran Zhao
Xiaozhuo Liu
Jiancheng Chen
Zhiqi Mao
Mei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1529647

11,894 views
2 citations

Original Research

Published on 04 Apr 2025

The ultrafine powder of atractylodis macrocephalae rhizoma improves immune function in naturally aging rats by regulating the PI3K/Akt/NF-κB signaling pathway

in Translational Pharmacology

Wang Yu
Su Jie
Gao Su
Niu Zhuangwei
Zhou Yiqing
Chen Suhong
Lv Guiyuan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550357

2,909 views
2 citations

Original Research

Published on 02 Apr 2025

Male mice treated with combined anti-fibrotic therapeutics, IPW5371 and tadalafil, are predisposed to adverse cardiovascular events

in Translational Pharmacology

Jazz Q. Stephens
Uriel Blas-Machado
Chrissy Sherrill
David Caudell
Nancy Kock
Ashley M. Davis
Jordyn M. Whitfield
Barry Hart
Kylie Kavanagh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537494

2,034 views

Original Research

Published on 31 Mar 2025

Anti-CTLA-and anti-PD-1 immune checkpoint inhibitor antibodies impair human sperm motility in-vitro

in Translational Pharmacology

Ilaria Cosci
Luca De Toni
Paolo Del Fiore
Andrea Di Nisio
Samuela Carraro
Claudia Maria Radu
Loris Bertazza
Simone Mocellin
Jacopo Pigozzo
Giovanna Crivellaro

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534975

3,412 views
3 citations

Original Research

Published on 27 Mar 2025

Comparative efficacy of Pirfenidone and Meloxicam on early radiotherapy-induced anal sphincter dysfunction in rats

in Translational Pharmacology

Dragoș Viorel Scripcariu
Cezar Cătălin Caratașu
Mitică Ciorpac
Teodora Alexa-Stratulat
Andrei Szilagyi
Cristian Răzvan Buga
Bogdan Ionuţ Dobrovăț
Lucian Eva
Andrei Daniel Timofte
Ludmila Lozneanu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1441011

2,200 views

Clinical Trial

Published on 26 Mar 2025

A phase I study to evaluate the safety, tolerability, and pharmacokinetics of HEC113995PA·H2O, a novel dual-acting serotonergic antidepressant, in healthy subjects

in Translational Pharmacology

Xue Wu
Qingqing Wu
Qichen Ding
Yulei Zhuang
Lin Luo
Yingjun Zhang
Li Deng
Chuanfei Jin
Xue Li
Zhangma Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1500974

1,898 views

Original Research

Published on 26 Mar 2025

Metformin attenuates diabetic osteoporosis by suppressing ferroptosis via the AMPK/Nrf2 pathway

in Translational Pharmacology

Yanwei Liu
Zhaoyu Fu
Xinyu Wang
Qifan Yang
Shun Liu
Dong Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1527316

5,460 views
8 citations

Original Research

Published on 25 Mar 2025

Potential effects of lipid lowering and antioxidant activity of exosomes from Phascolosoma esculenta: in vivo and in vitro studies

in Translational Pharmacology

Lin Yang
Xue Yi
Meitao Duan
Ahmed Mahal
Binbin Chen
Zhiqiang Zhang
Jungang Ren
Ming Chen
Chen Meng
Moxun Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560462

2,032 views
1 citation

Clinical Trial

Published on 21 Mar 2025

The effect of high-fat diet on the pharmacokinetics of ondansetron hydrochloride tablets in healthy Chinese subjects

in Translational Pharmacology

Na Zhao
Caiyun Jia
Yiting Hu
Xue Sun
Haojing Song
Bo Qiu
Wanjun Bai
Zhanjun Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1512857

3,211 views

Original Research

Published on 20 Mar 2025

Metformin inhibits pathological retinal neovascularization but promotes retinal fibrosis in experimental neovascular age-related macular degeneration

in Translational Pharmacology

Xin Wang
Xu Liang
Shiya Huang
Mingyan Wei
Yuan Xu
Xiaodong Chen
Yanliang Miao
Rongrong Zong
Xiang Lin
Shiying Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1547492

3,581 views
2 citations

Clinical Trial

Published on 19 Mar 2025

The adjunctive role of metformin in patients with mild to moderate ulcerative colitis: a randomized controlled study

in Translational Pharmacology

Ammena Y. Binsaleh
Sahar M. El-Haggar
Sahar K. Hegazy
Maha M. Maher
Monir M. Bahgat
Thanaa A. Elmasry
Sarah Alrubia
Amsha S. Alsegiani
Mamdouh Eldesoqui
Mostafa M. Bahaa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1507009

4,669 views
5 citations

1,097 articles

articles

Glucagon-like peptide-1, fibroblast growth factor 21, and other endocrine responses to alcohol ingestion in women before and after metabolic surgery

Advances in biomaterials for osteonecrosis treatment

A novel adenosine-to-inosine RNA editing-based nomogram for predicting prognosis of hepatocellular carcinoma

BCAA metabolism in cancer progression and therapy resistance: The balance between fuel and cell signaling

Metabolite 2-aminoadipic acid: implications for metabolic disorders and therapeutic opportunities

Randomized, double-blind, placebo-controlled pilot study of metformin as an adjunctive therapy in Parkinson’s disease

Unveiling p65 as the target of diphyllin in ameliorating metabolic dysfunction-associated steatotic liver disease via targeted protein degradation technology

Tacrolimus exposure during the three-month period following allogeneic stem cell transplantation predicts overall survival

Metformin in gynecological disorders: pathogenic insights and therapeutic implications

Development of an adipocyte differentiation protocol using 3T3-L1 cells for the investigation of the browning process: identification of the PPAR-γ agonist rosiglitazone as a browning reference drug

Ultrasensitive RNase H activity detection using the transcription-based hybrid probe and CRISPR/cas12a signal amplifier

Carnosine alleviates oxidative stress to prevent cellular senescence by regulating Nrf2/HO-1 pathway: a promising anti-aging strategy for oral mucosa

HPLC-UV method development and validation for anticancer drug sorafenib and the co-prescribed drug dexamethasone: application to pharmacokinetic evaluation of sorafenib nanoformulations

The efficacy of different doses of citicoline in improving the prognosis of patients with acute ischemic stroke based on network meta-analysis

The ultrafine powder of atractylodis macrocephalae rhizoma improves immune function in naturally aging rats by regulating the PI3K/Akt/NF-κB signaling pathway

Male mice treated with combined anti-fibrotic therapeutics, IPW5371 and tadalafil, are predisposed to adverse cardiovascular events

Anti-CTLA-and anti-PD-1 immune checkpoint inhibitor antibodies impair human sperm motility in-vitro

Comparative efficacy of Pirfenidone and Meloxicam on early radiotherapy-induced anal sphincter dysfunction in rats

A phase I study to evaluate the safety, tolerability, and pharmacokinetics of HEC113995PA·H2O, a novel dual-acting serotonergic antidepressant, in healthy subjects

Metformin attenuates diabetic osteoporosis by suppressing ferroptosis via the AMPK/Nrf2 pathway

Potential effects of lipid lowering and antioxidant activity of exosomes from Phascolosoma esculenta: in vivo and in vitro studies

The effect of high-fat diet on the pharmacokinetics of ondansetron hydrochloride tablets in healthy Chinese subjects

Metformin inhibits pathological retinal neovascularization but promotes retinal fibrosis in experimental neovascular age-related macular degeneration

The adjunctive role of metformin in patients with mild to moderate ulcerative colitis: a randomized controlled study