Frontiers in Pharmacology

Original Research

Published on 19 Jan 2022

Hermansky-Pudlak Syndrome: Identification of Novel Variants in the Genes HPS3, HPS5, and DTNBP1 (HPS-7)

Doris Boeckelmann
Mira Wolter
Katharina Neubauer
Felix Sobotta
Antonia Lenz
Hannah Glonnegger
Barbara Käsmann-Kellner
Jasmin Mann
Stephan Ehl
Barbara Zieger

Frontiers in Pharmacology

doi 10.3389/fphar.2021.786937

5,763 views
14 citations

Original Research

Published on 18 Jan 2022

Population Pharmacokinetic Modeling and Simulation of TQ-B3101 to Inform Dosing in Pediatric Patients With Solid Tumors

Fen Yang
Huali Wu
Yunhai Bo
Ye Lu
Hong Pan
Su Li
Qin Lu
Simin Xie
Harry Liao
Bing Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.782518

3,611 views
3 citations

Original Research

Published on 18 Jan 2022

Kinsenoside Alleviates Alcoholic Liver Injury by Reducing Oxidative Stress, Inhibiting Endoplasmic Reticulum Stress, and Regulating AMPK-Dependent Autophagy

Limin Gao
Xingyu Chen
Zeyu Fu
Jie Yin
Yafen Wang
Weiguang Sun
Hong Ren
Yonghui Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.747325

8,178 views
32 citations

Original Research

Published on 18 Jan 2022

Synthesis, Characterization, and in vivo Evaluation of a Novel Potent Autotaxin-Inhibitor

Daniel Hunziker
Sabrina Reinehr
Marina Palmhof
Natalie Wagner
Thomas Biniasch
Gesa Stute
Patrizio Mattei
Petra Schmitz
Patrick DiGiorgio
Jérôme Hert

Frontiers in Pharmacology

doi 10.3389/fphar.2021.699535

12,235 views
11 citations

Systematic Review

Published on 18 Jan 2022

Comparison of Systemic Treatments for Metastatic Castration-Resistant Prostate Cancer After Docetaxel Failure: A Systematic Review and Network Meta-analysis

Junru Chen
Yaowen Zhang
Xingming Zhang
Jinge Zhao
Yuchao Ni
Sha Zhu
Ben He
Jindong Dai
Zhipeng Wang
Zilin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.789319

9,522 views
21 citations

Original Research

Published on 18 Jan 2022

Targeting Myadm to Intervene Pulmonary Hypertension on Rats Before Pregnancy Alleviates the Effect on Their Offspring’s Cardiac-Cerebral Systems

Jingrong Wang
Zirui Zhang
Cui Liang
Tingting Lv
Haoying Yu
Shuyue Ren
Peirong Lin
Guanhua Du
Lan Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2021.791370

3,707 views
3 citations

Systematic Review

Published on 18 Jan 2022

Effect of Urate-Lowering Therapy on the Progression of Kidney Function in Patients With Asymptomatic Hyperuricemia: A Systematic Review and Meta-Analysis

Lin Zhang
Kang An
Xingyu Mou
Mei Zhang
Qiaoli Su
Shuangqing Li

Frontiers in Pharmacology

doi 10.3389/fphar.2021.795082

6,313 views
22 citations

Original Research

Published on 18 Jan 2022

Cilostazol Ameliorates Peripheral Neuropathic Pain in Streptozotocin-Induced Type I Diabetic Rats

Kuang-I. Cheng
Hung-Chen Wang
Kuang-Yi Tseng
Yi-Hsuan Wang
Chung-Yu Chang
Yi-Jing Chen
Chung-Sheng Lai
Dar-Ren Chen
Lin-Li Chang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.771271

5,616 views
22 citations

Review

Published on 18 Jan 2022

Anti-Inflammatory and Pro-Autophagy Effects of the Cannabinoid Receptor CB2R: Possibility of Modulation in Type 1 Diabetes

Qing-Rong Liu
Kanikkai Raja Aseer
Qin Yao
Xiaoming Zhong
Paritosh Ghosh
Jennifer F. O’Connell
Josephine M. Egan

Frontiers in Pharmacology

doi 10.3389/fphar.2021.809965

12,130 views
13 citations

Original Research

Published on 18 Jan 2022

Intravenous Immunoglobulin Combined With Corticosteroids for the Treatment of Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis: A Propensity-Matched Retrospective Study in China

Lu Yang
Yan-Hong Shou
Feng Li
Xiao-Hua Zhu
Yong-Sheng Yang
Jin-Hua Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.750173

6,433 views
16 citations

Methods

Published on 18 Jan 2022

AOPM: Application of Antioxidant Protein Classification Model in Predicting the Composition of Antioxidant Drugs

Yixiao Zhai
Jingyu Zhang
Tianjiao Zhang
Yue Gong
Zixiao Zhang
Dandan Zhang
Yuming Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2021.818115

3,718 views
3 citations

Original Research

Published on 18 Jan 2022

Pterocarpus santalinus Selectively Inhibits a Subset of Pro-Inflammatory Genes in Interleukin-1 Stimulated Endothelial Cells

Priscilla Natalia
Julia Zwirchmayr
Ieva Rudžionytė
Alexandra Pulsinger
Johannes M. Breuss
Pavel Uhrin
Judith M. Rollinger
Rainer de Martin

Frontiers in Pharmacology

doi 10.3389/fphar.2021.802153

3,388 views
3 citations

Original Research

Published on 18 Jan 2022

Folic Acid–Functionalized Metal-Organic Framework Nanoparticles as Drug Carriers Improved Bufalin Antitumor Activity Against Breast Cancer

Hairong Zeng
Chao Xia
Bei Zhao
Mengmeng Zhu
HaoYue Zhang
Die Zhang
Xin Rui
Huili Li
Yi Yuan

Frontiers in Pharmacology

doi 10.3389/fphar.2021.747992

7,819 views
33 citations

Original Research

Published on 18 Jan 2022

Autophagy Induced by Micheliolide Alleviates Acute Irradiation-Induced Intestinal Injury via Inhibition of the NLRP3 Inflammasome

Dong-ming Wu
Jing Li
Rong Shen
Jin Li
Ye Yu
Li Li
Shi-hua Deng
Teng Liu
Ting Zhang
Ying Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.773150

4,369 views
17 citations

Original Research

Published on 18 Jan 2022

The Effect and Safety of Iguratimod Combined With Methotrexate on Rheumatoid Arthritis: A Systematic Review and Meta-Analysis Based on a Randomized Controlled Trial

Liuting Zeng
Ganpeng Yu
Kailin Yang
Wensa Hao
Hua Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2021.780154

6,587 views
9 citations

Systematic Review

Published on 18 Jan 2022

Efficacy and Safety of Vadadustat for Anemia in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis

Limei Xiong
Hui Zhang
Yannan Guo
Yue Song
Yuhong Tao

Frontiers in Pharmacology

doi 10.3389/fphar.2021.795214

11,656 views
13 citations

Original Research

Published on 18 Jan 2022

A FAK Inhibitor Boosts Anti-PD1 Immunotherapy in a Hepatocellular Carcinoma Mouse Model

Yuhua Wei
Yufeng Wang
Nanbin Liu
Ran Qi
Yan Xu
Kun Li
Yu Feng
Baomin Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2021.820446

8,797 views
25 citations

Original Research

Published on 18 Jan 2022

Gentiana scabra Restrains Hepatic Pro-Inflammatory Macrophages to Ameliorate Non-Alcoholic Fatty Liver Disease

Yiyuan Zheng
Dan Fang
Chaoyuan Huang
Lina Zhao
Liming Gan
Youlan Chen
Fengbin Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.816032

6,475 views
15 citations

Original Research

Published on 18 Jan 2022

The Japanese Herbal Medicine Hangeshashinto Induces Oral Keratinocyte Migration by Mediating the Expression of CXCL12 Through the Activation of Extracellular Signal-Regulated Kinase

Kanako Miyano
Seiya Hasegawa
Noriho Asai
Miaki Uzu
Wakako Yatsuoka
Takao Ueno
Miki Nonaka
Hideaki Fujii
Yasuhito Uezono

Frontiers in Pharmacology

doi 10.3389/fphar.2021.695039

6,225 views
14 citations

Systematic Review

Published on 18 Jan 2022

Efficacy and Safety of Oral Acetaminophen for Premature Infants With Patent Ductus Arteriosus: A Meta-Analysis

Xie Zi-Yun
Zhang Ruo-lin
Xia Yue-wei
Bo Tao

Frontiers in Pharmacology

doi 10.3389/fphar.2021.696417

6,318 views
10 citations

Original Research

Published on 18 Jan 2022

Investigation of the Effects of the Short QT Syndrome D172N Kir2.1 Mutation on Ventricular Action Potential Profile Using Dynamic Clamp

Chunyun Du
Randall L. Rasmusson
Glenna C. Bett
Brandon Franks
Henggui Zhang
Jules C. Hancox

Frontiers in Pharmacology

doi 10.3389/fphar.2021.794620

2,931 views
13 citations

Systematic Review

Published on 18 Jan 2022

Effectiveness, Acceptability and Safety of Pharmaceutical Management for Combat-Related PTSD in Adults Based on Systematic Review of Twenty-Two Randomized Controlled Trials

Jin-Zhu Yan
Jia-Ling Liu
Xiao-Zheng Li
Zhi-Xin Zhang
Run-Ben Liu
Chao Zhang
Qin-Qin Gong

Frontiers in Pharmacology

doi 10.3389/fphar.2021.805354

6,236 views
1 citation

Review

Published on 18 Jan 2022

Traditional Chinese Medicine Targeting Heat Shock Proteins as Therapeutic Strategy for Heart Failure

Yanchun Wang
Junxuan Wu
Dawei Wang
Rongyuan Yang
Qing Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.814243

5,578 views
2 citations

Original Research

Published on 18 Jan 2022

PBK Enhances Cellular Proliferation With Histone H3 Phosphorylation and Suppresses Migration and Invasion With CDH1 Stabilization in Colorectal Cancer

Akira Koshino
Aya Nagano
Akinobu Ota
Toshinori Hyodo
Akane Ueki
Masayuki Komura
Akane Sugimura-Nagata
Masahide Ebi
Naotaka Ogasawara
Kenji Kasai

Frontiers in Pharmacology

doi 10.3389/fphar.2021.772926

4,311 views
19 citations

4,137 Publications

volumes

Hermansky-Pudlak Syndrome: Identification of Novel Variants in the Genes HPS3, HPS5, and DTNBP1 (HPS-7)

Population Pharmacokinetic Modeling and Simulation of TQ-B3101 to Inform Dosing in Pediatric Patients With Solid Tumors

Kinsenoside Alleviates Alcoholic Liver Injury by Reducing Oxidative Stress, Inhibiting Endoplasmic Reticulum Stress, and Regulating AMPK-Dependent Autophagy

Synthesis, Characterization, and in vivo Evaluation of a Novel Potent Autotaxin-Inhibitor

Comparison of Systemic Treatments for Metastatic Castration-Resistant Prostate Cancer After Docetaxel Failure: A Systematic Review and Network Meta-analysis

Targeting Myadm to Intervene Pulmonary Hypertension on Rats Before Pregnancy Alleviates the Effect on Their Offspring’s Cardiac-Cerebral Systems

Effect of Urate-Lowering Therapy on the Progression of Kidney Function in Patients With Asymptomatic Hyperuricemia: A Systematic Review and Meta-Analysis

Cilostazol Ameliorates Peripheral Neuropathic Pain in Streptozotocin-Induced Type I Diabetic Rats

Anti-Inflammatory and Pro-Autophagy Effects of the Cannabinoid Receptor CB2R: Possibility of Modulation in Type 1 Diabetes

Intravenous Immunoglobulin Combined With Corticosteroids for the Treatment of Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis: A Propensity-Matched Retrospective Study in China

AOPM: Application of Antioxidant Protein Classification Model in Predicting the Composition of Antioxidant Drugs

Pterocarpus santalinus Selectively Inhibits a Subset of Pro-Inflammatory Genes in Interleukin-1 Stimulated Endothelial Cells

Folic Acid–Functionalized Metal-Organic Framework Nanoparticles as Drug Carriers Improved Bufalin Antitumor Activity Against Breast Cancer

Autophagy Induced by Micheliolide Alleviates Acute Irradiation-Induced Intestinal Injury via Inhibition of the NLRP3 Inflammasome

The Effect and Safety of Iguratimod Combined With Methotrexate on Rheumatoid Arthritis: A Systematic Review and Meta-Analysis Based on a Randomized Controlled Trial

Efficacy and Safety of Vadadustat for Anemia in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis

A FAK Inhibitor Boosts Anti-PD1 Immunotherapy in a Hepatocellular Carcinoma Mouse Model

Gentiana scabra Restrains Hepatic Pro-Inflammatory Macrophages to Ameliorate Non-Alcoholic Fatty Liver Disease

The Japanese Herbal Medicine Hangeshashinto Induces Oral Keratinocyte Migration by Mediating the Expression of CXCL12 Through the Activation of Extracellular Signal-Regulated Kinase

Efficacy and Safety of Oral Acetaminophen for Premature Infants With Patent Ductus Arteriosus: A Meta-Analysis

Investigation of the Effects of the Short QT Syndrome D172N Kir2.1 Mutation on Ventricular Action Potential Profile Using Dynamic Clamp

Effectiveness, Acceptability and Safety of Pharmaceutical Management for Combat-Related PTSD in Adults Based on Systematic Review of Twenty-Two Randomized Controlled Trials

Traditional Chinese Medicine Targeting Heat Shock Proteins as Therapeutic Strategy for Heart Failure

PBK Enhances Cellular Proliferation With Histone H3 Phosphorylation and Suppresses Migration and Invasion With CDH1 Stabilization in Colorectal Cancer