Frontiers in Pharmacology

Original Research

Accepted on 12 Dec 2025

Computational-Experimental Integration Identifies Potent Carbohydrate-Hydrolyzing Enzyme Inhibitors from Nardostachys jatamansi: Molecular Docking, Dynamics and Pharmacokinetic Predictions

Muhammad Javid Iqbal
Iqra Malik
Gonzalo Bernal
Alexis M Salas-Burgos
Luis A. Salazar

Frontiers in Pharmacology

178 views

Review

Accepted on 12 Dec 2025

Epilepsy, neuroinflammation and cannabidiol What do we know thus far?

Gabriela Pesántez Ríos
Emilio Perucca
Pasquale Striano
Roberto Horacio Caraballo
Ximena Pesantez Rios
Samuel Ignacio Pascual Pascual
Galo Pesantez Cuesta

Frontiers in Pharmacology

175 views

Review

Published on 12 Dec 2025

Relevant pharmacokinetics, bioavailability, and bioequivalence studies on Chlorpheniramine maleate (various species): a review

César Alas-Pineda
Dennis J. Pavón-Varela
Kristhel Gaitán-Zambrano
Gustavo Ferrer

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1737690

1,064 views

Methods

Published on 12 Dec 2025

Development of an LC-MS/MS method to quantitatively analyze escitalopram and its metabolites with application in liver and placenta microsome metabolism

Yifei Shen
Bingyi Yao
Yuanqing Guo
Yujia Yang
Chenmeizi Liang
Junze Huang
Yuanjin Zhang
Xin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714686

643 views

Original Research

Published on 12 Dec 2025

Targeting lipogenesis promotes the synergistic effect of the selective HDAC6 inhibitor ITF3756 with bortezomib in colon cancer cells

Marzia Franzò
Chiara Zichittella
Diana Di Liberto
Giovanni Pratelli
Federica Affranchi
Antonietta Notaro
Michela Giuliano
Sonia Emanuele

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706770

793 views

Review

Published on 12 Dec 2025

Clinical relevance of PLK1 in epithelial ovarian cancer

Xiaochang Shen
Jiandong Wang
Shuning Chen
Haomeng Zhang
Chunxiao Zhou
Victoria L. Bae-Jump

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702273

539 views

Editorial

Published on 12 Dec 2025

Editorial: Cell death in kidney diseases: novel biomarkers, mechanisms, and therapeutic strategies

Min Chen
Yu Ning Liu
Wei Jing Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715728

514 views

Original Research

Published on 12 Dec 2025

Medication adherence in the elderly population with chronic diseases: a factor analysis

Doris Cardona
Valeria Santacruz-Restrepo
Alejandra Rendón-Montoya
Juliana Madrigal-Cadavid
Alejandra Segura-Cardona
Jorge Iván Estrada-Acevedo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699999

681 views

Original Research

Published on 12 Dec 2025

Real-world disproportionality analysis of sleep disturbances associated with antiseizure medications in epilepsy: a pharmacovigilance study

Chen Gou
Mengshi Yang
Qingqing Zhao
Yanbing Han

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1740747

898 views

Original Research

Published on 12 Dec 2025

Exploring HSP90α and hs-CRP using AI models to predict prognosis in advanced hepatocellular carcinoma treated with PD-1 inhibitors and targeted therapy

Zhen-Ying Wu
Xueting Li
Lu Yang
Yuhui Shi
Xianguo Liu
Lianbin Wen
Yanqiong Song
Wanyun Du
Yulin Tu
Qian Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1726967

610 views

Original Research

Published on 12 Dec 2025

Coreopsis tinctoria Nutt. attenuates ultraviolet A photodamage by suppressing endoplasmic reticulum stress-induced apoptosis via Nrf2 crosstalk

Ling Liang
Xin Nie
Nan Zhao
Menggeng Li
Mingjie Li
Zhiwei Li
Man Wu
Xuanmin Wu
Cheuk-Lun Lee
Peng Shu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686234

550 views

Original Research

Published on 12 Dec 2025

Alginate-encapsulated muscle-derived stem cell spheroids promote muscle regeneration in a murine model of volumetric muscle loss

Lucas Pari Mitre
Giovana Zanetti Ivanov
Shahin Shams
Fabio Yamaguchi
André Petraconi
Ricardo Jorge Espanhol Andrade
Eduardo Silva
Leonardo Martin
Roberta Sessa Stilhano

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657563

764 views

Original Research

Accepted on 11 Dec 2025

Network Pharmacology-Based Identification of Potential Drug Targets and Bioactive Compounds in Lycii Fructus (Gouqizi) for the Therapeutics of Parkinson's Disease

Sufana Al Hashmi
Rana Adnan Tahir
Sheikh Arslan Sehgal

Frontiers in Pharmacology

439 views

Original Research

Accepted on 11 Dec 2025

Medication use in Poland for children and adolescents with Neurodevelopmental disorders: before, during and after the COVID-19 pandemic - a retrospective pharmacoepidemiological study using national reimbursement data

Andrzej Silczuk
Malwina Holownia-Voloskova
Anna Mosiolek
Otton Roubinek
Katarzyna Bliźniewska-Kowalska
Krzysztof Zakrzewski
Marcin Czech

Frontiers in Pharmacology

201 views

Correction

Accepted on 11 Dec 2025

Correction: Nafamostat mesilate attenuates renal fibrosis by suppressing the IL-17 signaling pathway

Weili Liao
Rui Fan
Yuman Du
Hairong Wang
Yong Yang
Yuan Tian

Frontiers in Pharmacology

108 views

Review

Accepted on 11 Dec 2025

Cardioprotection for radiation-induced heart disease in breast cancer patients

Sabina Mędrek
Kasper Rolek
Jakub Homotnik
Sebastian Szmit

Frontiers in Pharmacology

106 views

Original Research

Accepted on 11 Dec 2025

Drug-Induced Peripheral Nerve Palsy: A Real-World Study Based on FAERS Data from 2004 to the Third Quarter of 2024

Yingjie Li
Xueliang Yi
Neng-Wei Yu

Frontiers in Pharmacology

126 views

Review

Accepted on 11 Dec 2025

Advances in pulmonary neuroendocrine cells and their cellular interactions in asthma pathogenesis

Lanlan Wang
Hui Wang
Yamei Yuan
Weidong Ye
Xiangming Fang

Frontiers in Pharmacology

136 views

Original Research

Accepted on 11 Dec 2025

Pteryxin enhances human NK-cell cytotoxicity by upregulating NKp30, NKp46, and 2B4 via ERK/AKT signaling

EUN SUN PARK
Jong-Tae Kim
Yo-Sep Hwang
Jahyeong Han
Hyo-Min Park
Hyang Ran Yoon
Hee Jun Cho
Hee Gu Lee

Frontiers in Pharmacology

139 views

Original Research

Accepted on 11 Dec 2025

TLR4 Modulates Simvastatin's Impact on HDL Cholesterol and Glycemic Control

Xiao Tian
Peixiang Zhang

Frontiers in Pharmacology

168 views

Original Research

Published on 11 Dec 2025

Practical utility of meropenem therapeutic drug monitoring: a systematic review of evidence for clinical application

Yi-Chang Zhao
Jia-Yi Liu
Jia-Kai Li
Huai-Yuan Liu
Zhi-Hua Sun
Bi-Kui Zhang
Miao Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1725419

1,019 views

Original Research

Published on 11 Dec 2025

Impact of the diverse cardiotonic steroids on beta-amyloid precursor protein level

Irina Yu. Petrushanko
Denis R. Lisitskii
Maria A. Strelkova
Anna P. Tolstova
Artemy P. Fedulov
Filipp A. Filonov
Vladimir A. Mitkevich
Alexander A. Makarov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1723629

547 views

Correction

Published on 11 Dec 2025

Correction: Anticancer effects of OSW-1 on glioma cells via regulation of the PI3K/AKT signal pathway: a network pharmacology approach and experimental validation in vitro and in vivo

Zhixin Zhan
Ziqiang Liu
Chaochao Zhang
Haijun Gao
Jiacheng Lai
Yong Chen
Haiyan Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1754450

375 views

Original Research

Published on 11 Dec 2025

Xin-Fu-Kang oral liquid improves cardiac function and attenuates miR-223–associated NF-κB/NLRP3 pyroptotic signaling in chronic heart failure

Zelin Ye
Mingrui Liu
Xiaohan Zhang
Huaqin Wu
Zhiling Qiu
Ruoning Chai
Yuanhui Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697422

794 views

29,106 Publications

volumes

Volume 16 - 2025

Computational-Experimental Integration Identifies Potent Carbohydrate-Hydrolyzing Enzyme Inhibitors from Nardostachys jatamansi: Molecular Docking, Dynamics and Pharmacokinetic Predictions

Epilepsy, neuroinflammation and cannabidiol What do we know thus far?

Relevant pharmacokinetics, bioavailability, and bioequivalence studies on Chlorpheniramine maleate (various species): a review

Development of an LC-MS/MS method to quantitatively analyze escitalopram and its metabolites with application in liver and placenta microsome metabolism

Targeting lipogenesis promotes the synergistic effect of the selective HDAC6 inhibitor ITF3756 with bortezomib in colon cancer cells

Clinical relevance of PLK1 in epithelial ovarian cancer

Editorial: Cell death in kidney diseases: novel biomarkers, mechanisms, and therapeutic strategies

Medication adherence in the elderly population with chronic diseases: a factor analysis

Real-world disproportionality analysis of sleep disturbances associated with antiseizure medications in epilepsy: a pharmacovigilance study

Exploring HSP90α and hs-CRP using AI models to predict prognosis in advanced hepatocellular carcinoma treated with PD-1 inhibitors and targeted therapy

Coreopsis tinctoria Nutt. attenuates ultraviolet A photodamage by suppressing endoplasmic reticulum stress-induced apoptosis via Nrf2 crosstalk

Alginate-encapsulated muscle-derived stem cell spheroids promote muscle regeneration in a murine model of volumetric muscle loss

Network Pharmacology-Based Identification of Potential Drug Targets and Bioactive Compounds in Lycii Fructus (Gouqizi) for the Therapeutics of Parkinson's Disease

Medication use in Poland for children and adolescents with Neurodevelopmental disorders: before, during and after the COVID-19 pandemic - a retrospective pharmacoepidemiological study using national reimbursement data

Correction: Nafamostat mesilate attenuates renal fibrosis by suppressing the IL-17 signaling pathway

Cardioprotection for radiation-induced heart disease in breast cancer patients

Drug-Induced Peripheral Nerve Palsy: A Real-World Study Based on FAERS Data from 2004 to the Third Quarter of 2024

Advances in pulmonary neuroendocrine cells and their cellular interactions in asthma pathogenesis

Pteryxin enhances human NK-cell cytotoxicity by upregulating NKp30, NKp46, and 2B4 via ERK/AKT signaling

TLR4 Modulates Simvastatin's Impact on HDL Cholesterol and Glycemic Control

Practical utility of meropenem therapeutic drug monitoring: a systematic review of evidence for clinical application

Impact of the diverse cardiotonic steroids on beta-amyloid precursor protein level

Correction: Anticancer effects of OSW-1 on glioma cells via regulation of the PI3K/AKT signal pathway: a network pharmacology approach and experimental validation in vitro and in vivo

Xin-Fu-Kang oral liquid improves cardiac function and attenuates miR-223–associated NF-κB/NLRP3 pyroptotic signaling in chronic heart failure