Frontiers in Pharmacology

Original Research

Published on 21 Dec 2022

Proteomic analysis revealed the pharmacological mechanism of Xueshuantong injection in preventing early acute myocardial infarction injury

Aoao Wang
Ying Li
Ziyan Wang
Gaojie Xin
Yue You
Mingqian Sun
Lan Miao
Lei Li
Yinghong Pan
Jianxun Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1010079

4,778 views
6 citations

Review

Published on 21 Dec 2022

Role of bioactive compounds in the treatment of hepatitis: A review

Arpita Roy
Madhura Roy
Amel Gacem
Shreeja Datta
Md. Zeyaullah
Khursheed Muzammil
Thoraya A. Farghaly
Magda H. Abdellattif
Krishna Kumar Yadav
Jesus Simal-Gandara

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1051751

15,633 views
16 citations

Original Research

Published on 21 Dec 2022

Clinical efficacy of azacytidine and venetoclax and prognostic impact of Tim-3 and galectin-9 in acute myeloid leukemia and high-risk myelodysplastic syndromes: A single-center real-life experience

Valentina Giudice
Bianca Serio
Idalucia Ferrara
Paola Manzo
Marisa Gorrese
Rita Pepe
Angela Bertolini
Francesca D’Alto
Francesco Verdesca
Maddalena Langella

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1052060

9,788 views
7 citations

Review

Published on 21 Dec 2022

The role of Phosphodiesterase-1 and its natural product inhibitors in Alzheimer’s disease: A review

Nazir Ahmad
Kaisun Nesa Lesa
Ari Sudarmanto
Nanang Fakhrudin
Zullies Ikawati

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1070677

9,862 views
18 citations

Original Research

Published on 21 Dec 2022

Drug repositioning based on heterogeneous networks and variational graph autoencoders

Song Lei
Xiujuan Lei
Lian Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1056605

3,823 views
6 citations

Clinical Trial

Published on 21 Dec 2022

Efficacy and safety of ciprofol-remifentanil versus propofol-remifentanil during fiberoptic bronchoscopy: A prospective, randomized, double-blind, non-inferiority trial

Bin Wu
Wenchao Zhu
Qinghe Wang
Chunguang Ren
Lizhen Wang
Guannan Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1091579

8,454 views
48 citations

Review

Published on 21 Dec 2022

Triplex-forming oligonucleotides as an anti-gene technique for cancer therapy

Chun Li
Zunzhen Zhou
Chao Ren
Yi Deng
Feng Peng
Qiongfen Wang
Hong Zhang
Yuan Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1007723

8,937 views
30 citations

Original Research

Published on 21 Dec 2022

Exploring the effects of drug, disease, and protein dependencies on biomedical named entity recognition: A comparative analysis

Peifu Han
Xue Li
Xun Wang
Shuang Wang
Changnan Gao
Wenqi Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1020759

3,076 views
11 citations

Original Research

Published on 21 Dec 2022

Cyclovirobuxine D, a cardiovascular drug from traditional Chinese medicine, alleviates inflammatory and neuropathic pain mainly via inhibition of voltage-gated Cav3.2 channels

Deyuan Su
Ye Gong
Songyu Li
Jian Yang
Yin Nian

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1081697

5,900 views
13 citations

Original Research

Published on 21 Dec 2022

Liver-related long-term outcomes of alpha-glucosidase inhibitors in patients with diabetes and liver cirrhosis

Fu-Shun Yen
Ming-Chih Hou
James Cheng-Chung Wei
Ying-Hsiu Shih
Chung Y. Hsu
Chih-Cheng Hsu
Chii-Min Hwu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1049094

4,127 views
6 citations

Review

Published on 21 Dec 2022

The potential function and clinical application of FGF21 in metabolic diseases

Zhiwei Chen
Lili Yang
Yang Liu
Ping Huang
Haiyan Song
Peiyong Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1089214

14,783 views
59 citations

Original Research

Published on 21 Dec 2022

Myriocin enhances the antifungal activity of fluconazole by blocking the membrane localization of the efflux pump Cdr1

Hongkang Wang
Zhe Ji
Yanru Feng
Tianhua Yan
Yongbing Cao
Hui Lu
Yuanying Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1101553

4,048 views
28 citations

Original Research

Published on 21 Dec 2022

Comprehensive metabolomics and lipidomics profiling uncovering neuroprotective effects of Ginkgo biloba L. leaf extract on Alzheimer’s disease

Li-Wei Liu
He-Ying Yue
Jing Zou
Meng Tang
Fan-Mei Zou
Zhuo-Lun Li
Qing-Quan Jia
Yu-Bo Li
Jian Kang
Li-Hua Zuo

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1076960

7,086 views
14 citations

Original Research

Published on 21 Dec 2022

Effects of the Radix Ginseng and Semen Ziziphi Spinosae drug pair on the GLU/GABA-GLN metabolic cycle and the intestinal microflora of insomniac rats based on the brain–gut axis

Tie Qiao
Yuan Wang
Ke Liang
Bingyuan Zheng
Jin Ma
Fangxiao Li
Chi Liu
Mingdan Zhu
Meng Song

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1094507

6,341 views
22 citations

Original Research

Published on 21 Dec 2022

A KCNB1 gain of function variant causes developmental delay and speech apraxia but not seizures

Emma L. Veale
Alessia Golluscio
Katheryn Grand
John M. Graham
Alistair Mathie

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1093313

4,365 views
16 citations

Original Research

Published on 21 Dec 2022

Cuproptosis-related lncRNA signatures predict prognosis and immune relevance of kidney renal papillary cell carcinoma

Tongjin Xie
Bin Liu
Dongbo Liu
Yusong Zhou
Qingping Yang
Dai Wang
Mengjie Tang
Wei Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1103986

4,880 views
8 citations

Original Research

Published on 21 Dec 2022

Reversal of spatial memory impairment by phosphodiesterase 3 inhibitor cilostazol is associated with reduced neuroinflammation and increased cerebral glucose uptake in aged male mice

Shuichi Yanai
Tetsuro Tago
Jun Toyohara
Tomoko Arasaki
Shogo Endo

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1031637

3,790 views
13 citations

Original Research

Published on 20 Dec 2022

Qing-Re-Xiao-Zheng-Yi-Qi formula relieves kidney damage and activates mitophagy in diabetic kidney disease

Qiaoru Wu
Runze Yan
Hanwen Yang
Yixuan Wang
Chao Zhang
Jiale Zhang
Zhaoli Cui
Yaoxian Wang
Weiwei Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2022.992597

6,409 views
13 citations

Review

Published on 20 Dec 2022

Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies

Edward Pajarillo
Ivan Nyarko-Danquah
Alexis Digman
Harpreet Kaur Multani
Sanghoon Kim
Patric Gaspard
Michael Aschner
Eunsook Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1011947

9,906 views
39 citations

Clinical Trial

Published on 20 Dec 2022

Low-dose esketamine for the prevention of emergency agitation in children after tonsillectomy: A randomized controlled study

Qi Li
Jiaming Fan
Wangping Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.991581

4,467 views
25 citations

Perspective

Published on 20 Dec 2022

An approach to data collection in compassionate use/managed access

Séverine Sarp
Ramona Reichenbach
Paul Aliu

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1095860

8,094 views
10 citations

Original Research

Published on 20 Dec 2022

Combination of the parent analogue of remdesivir (GS-441524) and molnupiravir results in a markedly potent antiviral effect in SARS-CoV-2 infected Syrian hamsters

Rana Abdelnabi
Piet Maes
Steven de Jonghe
Birgit Weynand
Johan Neyts

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1072202

6,022 views
22 citations

Original Research

Published on 20 Dec 2022

Serial five-membered lactone ring ions in the treatment of Alzheimer’s diseases-comprehensive profiling of arctigenin metabolites and network analysis

Yanan Li
Xianming Lan
Shaoping Wang
Yifang Cui
Shuyi Song
Hongyan Zhou
Qiyan Li
Long Dai
Jiayu Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1065654

2,970 views
8 citations

Original Research

Published on 20 Dec 2022

Astragaloside IV improves the pharmacokinetics of febuxostat in rats with hyperuricemic nephropathy by regulating urea metabolism in gut microbiota

Zhen Xiong Zhao
Xiao Hui Tang
Sheng Lu Jiang
Jia Qian Pang
Yu Bin Xu
Dan Dan Yuan
Ling Ling Zhang
Hui Min Liu
Qing Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1031509

5,681 views
14 citations

5,553 Publications

volumes

Proteomic analysis revealed the pharmacological mechanism of Xueshuantong injection in preventing early acute myocardial infarction injury

Role of bioactive compounds in the treatment of hepatitis: A review

Clinical efficacy of azacytidine and venetoclax and prognostic impact of Tim-3 and galectin-9 in acute myeloid leukemia and high-risk myelodysplastic syndromes: A single-center real-life experience

The role of Phosphodiesterase-1 and its natural product inhibitors in Alzheimer’s disease: A review

Drug repositioning based on heterogeneous networks and variational graph autoencoders

Efficacy and safety of ciprofol-remifentanil versus propofol-remifentanil during fiberoptic bronchoscopy: A prospective, randomized, double-blind, non-inferiority trial

Triplex-forming oligonucleotides as an anti-gene technique for cancer therapy

Exploring the effects of drug, disease, and protein dependencies on biomedical named entity recognition: A comparative analysis

Cyclovirobuxine D, a cardiovascular drug from traditional Chinese medicine, alleviates inflammatory and neuropathic pain mainly via inhibition of voltage-gated Cav3.2 channels

Liver-related long-term outcomes of alpha-glucosidase inhibitors in patients with diabetes and liver cirrhosis

The potential function and clinical application of FGF21 in metabolic diseases

Myriocin enhances the antifungal activity of fluconazole by blocking the membrane localization of the efflux pump Cdr1

Comprehensive metabolomics and lipidomics profiling uncovering neuroprotective effects of Ginkgo biloba L. leaf extract on Alzheimer’s disease

Effects of the Radix Ginseng and Semen Ziziphi Spinosae drug pair on the GLU/GABA-GLN metabolic cycle and the intestinal microflora of insomniac rats based on the brain–gut axis

A KCNB1 gain of function variant causes developmental delay and speech apraxia but not seizures

Cuproptosis-related lncRNA signatures predict prognosis and immune relevance of kidney renal papillary cell carcinoma

Reversal of spatial memory impairment by phosphodiesterase 3 inhibitor cilostazol is associated with reduced neuroinflammation and increased cerebral glucose uptake in aged male mice

Qing-Re-Xiao-Zheng-Yi-Qi formula relieves kidney damage and activates mitophagy in diabetic kidney disease

Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies

Low-dose esketamine for the prevention of emergency agitation in children after tonsillectomy: A randomized controlled study

An approach to data collection in compassionate use/managed access

Combination of the parent analogue of remdesivir (GS-441524) and molnupiravir results in a markedly potent antiviral effect in SARS-CoV-2 infected Syrian hamsters

Serial five-membered lactone ring ions in the treatment of Alzheimer’s diseases-comprehensive profiling of arctigenin metabolites and network analysis

Astragaloside IV improves the pharmacokinetics of febuxostat in rats with hyperuricemic nephropathy by regulating urea metabolism in gut microbiota