Frontiers in Pharmacology

Original Research

Published on 14 Jan 2022

The Effects of Combined Therapy With Metformin and Hydroxypropyl-β-Cyclodextrin in a Mouse Model of Niemann-Pick Disease Type C1

Jiang Du
Xinlei Liu
Yan Zhang
Xiaojing Han
Chunya Ma
Yanli Liu
Lihong Guan
Liang Qiao
Juntang Lin

Frontiers in Pharmacology

doi 10.3389/fphar.2021.825425

4,393 views
6 citations

Original Research

Published on 14 Jan 2022

Assessment of the Current State of Pharmacovigilance System in Pakistan Using Indicator-Based Assessment Tool

Muhammad Akhtar Abbas Khan
Saima Hamid
Tofeeq Ur-Rehman
Zaheer-Ud-Din Babar

Frontiers in Pharmacology

doi 10.3389/fphar.2021.789103

11,015 views
11 citations

Original Research

Published on 14 Jan 2022

Development of IKATP Ion Channel Blockers Targeting Sulfonylurea Resistant Mutant KIR6.2 Based Channels for Treating DEND Syndrome

Marien J. C. Houtman
Theres Friesacher
Xingyu Chen
Eva-Maria Zangerl-Plessl
Marcel A. G. van der Heyden
Anna Stary-Weinzinger

Frontiers in Pharmacology

doi 10.3389/fphar.2021.814066

5,524 views
9 citations

Editorial

Published on 14 Jan 2022

Editorial: Classical and Modern Biotechnology Applied to the Treatment of Epilepsy and Anxiety Disorders

R. O. Beleboni
M. R. Mortari
L. Melo-Thomas
N. C. Coimbra

Frontiers in Pharmacology

doi 10.3389/fphar.2021.824986

2,162 views
1 citation

Mini Review

Published on 14 Jan 2022

The Arsenal of Bioactive Molecules in the Skin Secretion of Urodele Amphibians

Ana L. A. N. Barros
Abdelaaty Hamed
Mariela Marani
Daniel C. Moreira
Peter Eaton
Alexandra Plácido
Massuo J. Kato
José Roberto S. A. Leite

Frontiers in Pharmacology

doi 10.3389/fphar.2021.810821

6,485 views
13 citations

Perspective

Published on 14 Jan 2022

Enhancing Choices Regarding the Administration of Insulin Among Patients With Diabetes Requiring Insulin Across Countries and Implications for Future Care

Ileana Mardare
Stephen M. Campbell
Johanna C. Meyer
Israel Abebrese Sefah
Amos Massele
Brian Godman

Frontiers in Pharmacology

doi 10.3389/fphar.2021.794363

4,443 views
2 citations

Original Research

Published on 14 Jan 2022

MicroRNA-92a-3p Enhances Cisplatin Resistance by Regulating Krüppel-Like Factor 4-Mediated Cell Apoptosis and Epithelial-to-Mesenchymal Transition in Cervical Cancer

Jing Yang
Jing Hai
Xuecai Dong
Mengjie Zhang
Shufeng Duan

Frontiers in Pharmacology

doi 10.3389/fphar.2021.783213

3,609 views
9 citations

Original Research

Published on 14 Jan 2022

Targeting HSP90 Inhibits Proliferation and Induces Apoptosis Through AKT1/ERK Pathway in Lung Cancer

Mengyuan Niu
Bin Zhang
Li Li
Zhonglan Su
Wenyuan Pu
Chen Zhao
Lulu Wei
Panpan Lian
Renwei Lu
Ranran Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.724192

10,218 views
63 citations

Original Research

Published on 14 Jan 2022

A GSH/CB Dual-Controlled Self-Assembled Nanomedicine for High-Efficacy Doxorubicin-Resistant Breast Cancer Therapy

Yang Yang
Quanfeng Zhao
Zhe Peng
Yunjiang Zhou
Miao-Miao Niu
Lin Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2021.811724

3,088 views
6 citations

Original Research

Published on 14 Jan 2022

Comparative Effectiveness and Safety of Low-Dose Oral Anticoagulants in Patients With Atrial Fibrillation

Sylvie Perreault
Alice Dragomir
Robert Côté
Aurélie Lenglet
Simon de Denus
Marc Dorais
Brian White-Guay
James Brophy
Mireille E. Schnitzer
Marie-Pierre Dubé

Frontiers in Pharmacology

doi 10.3389/fphar.2021.812018

6,632 views
7 citations

Original Research

Published on 14 Jan 2022

Preclinical Evaluation of Dimethyl Itaconate Against Hepatocellular Carcinoma via Activation of the e/iNOS-Mediated NF-κB–Dependent Apoptotic Pathway

Anurag Kumar Gautam
Pranesh Kumar
Ritu Raj
Dinesh Kumar
Bolay Bhattacharya
P.S. Rajinikanth
Kumarappan Chidambaram
Tarun Mahata
Biswanath Maity
Sudipta Saha

Frontiers in Pharmacology

doi 10.3389/fphar.2021.823285

5,041 views
15 citations

Original Research

Published on 14 Jan 2022

Gypenosides Attenuate Pulmonary Fibrosis by Inhibiting the AKT/mTOR/c-Myc Pathway

Suqing Liu
Qingqing Yang
Binbin Dong
Chunhui Qi
Tao Yang
Ming Li
Shan He
Baojun Liu
Jinfeng Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.806312

6,000 views
16 citations

Original Research

Published on 14 Jan 2022

Platelet-Derived Growth Factor-BB Inhibits Intervertebral Disc Degeneration via Suppressing Pyroptosis and Activating the MAPK Signaling Pathway

Weikang Zhang
Yuhang Gong
Xiaohang Zheng
Jianxin Qiu
Ting Jiang
Lihua Chen
Fangying Lu
Xinhui Wu
Fengmin Cheng
Zhenghua Hong

Frontiers in Pharmacology

doi 10.3389/fphar.2021.799130

6,100 views
21 citations

Original Research

Published on 14 Jan 2022

Anti-Liver Fibrosis Activity and the Potential Mode of Action of Ruangan Granules: Integrated Network Pharmacology and Metabolomics

Xiaofei Shang
Huixin Yuan
Lixia Dai
Yang Liu
Jian He
Huan Chen
Hongyan Li
Xiuhui Li

Frontiers in Pharmacology

doi 10.3389/fphar.2021.754807

7,936 views
8 citations

Original Research

Published on 13 Jan 2022

Repurposing Tranexamic Acid as an Anticancer Agent

Mary E. Law
Bradley J. Davis
Amanda F. Ghilardi
Elham Yaaghubi
Zaafir M. Dulloo
Mengxiong Wang
Olga A. Guryanova
Coy D. Heldermon
Stephan C. Jahn
Ronald K. Castellano

Frontiers in Pharmacology

doi 10.3389/fphar.2021.792600

9,338 views
17 citations

Opinion

Published on 13 Jan 2022

COVID-19 and Periodontitis: A Dangerous Association?

Francisco Javier Silvestre
Cecilia Fabiana Márquez-Arrico

Frontiers in Pharmacology

doi 10.3389/fphar.2021.789681

8,207 views
17 citations

Original Research

Published on 13 Jan 2022

Molecular Mechanisms of Epileptic Encephalopathy Caused by KCNMA1 Loss-of-Function Mutations

Yu Yao
Dongxiao Qu
Xiaoping Jing
Yuxiang Jia
Qi Zhong
Limin Zhuo
Xingxing Chen
Guoyi Li
Lele Tang
Yudan Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.775328

9,543 views
23 citations

Original Research

Published on 13 Jan 2022

Interaction of Serum Alkaline Phosphatase and Folic Acid Treatment on Chronic Kidney Disease Progression in Treated Hypertensive Adults

Yuanyuan Zhang
Panpan He
Guobao Wang
Min Liang
Di Xie
Jing Nie
Chengzhang Liu
Yun Song
Lishun Liu
Binyan Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.753803

5,146 views
5 citations

Original Research

Published on 13 Jan 2022

Discovery of the Potential Novel Pharmacodynamic Substances From Zhi-Zi-Hou-Po Decoction Based on the Concept of Co-Decoction Reaction and Analysis Strategy

Xin Feng
Yuelin Bi
Jiaqi Wang
Tianyi Li
Gengyuan Yu
Tonghua Zhang
Haoran Xu
Chenning Zhang
Yikun Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2021.830558

5,848 views
10 citations

Review

Published on 13 Jan 2022

Cancer Chemoprevention: A Strategic Approach Using Phytochemicals

Mohan Shankar G.
Mundanattu Swetha
C K Keerthana
Tennyson P Rayginia
Ruby John Anto

Frontiers in Pharmacology

doi 10.3389/fphar.2021.809308

20,033 views
127 citations

Review

Published on 13 Jan 2022

Safety Evaluation of Natural Drugs in Chronic Skeletal Disorders: A Literature Review of Clinical Trials in the Past 20 years

Dongyang Zhou
Hao Zhang
Xu Xue
Yali Tao
Sicheng Wang
Xiaoxiang Ren
Jiacan Su

Frontiers in Pharmacology

doi 10.3389/fphar.2021.801287

7,783 views
28 citations

Original Research

Published on 13 Jan 2022

Amoxicillin Haptenation of α-Enolase is Modulated by Active Site Occupancy and Acetylation

Juan M. González-Morena
Francisco J. Sánchez-Gómez
Yolanda Vida
Ezequiel Pérez-Inestrosa
María Salas
María I. Montañez
Alessandra Altomare
Giancarlo Aldini
María A. Pajares
Dolores Pérez-Sala

Frontiers in Pharmacology

doi 10.3389/fphar.2021.807742

3,111 views
2 citations

Review

Published on 13 Jan 2022

Therapeutic Opportunities of GPBAR1 in Cholestatic Diseases

Fangling Zhang
Xiaolin Xiao
Yong Li
Hefei Wu
Xinyu Deng
Yinxiao Jiang
Wenwen Zhang
Jian Wang
Xiao Ma
Yanling Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2021.805269

6,251 views
15 citations

Original Research

Published on 13 Jan 2022

Discovery of Novel Reductive Elimination Pathway for 10-Hydroxywarfarin

Dakota L. Pouncey
Dustyn A. Barnette
Riley W. Sinnott
Sarah J. Phillips
Noah R. Flynn
Howard P. Hendrickson
S. Joshua Swamidass
Grover P. Miller

Frontiers in Pharmacology

doi 10.3389/fphar.2021.805133

4,199 views
1 citation

4,137 Publications

volumes

The Effects of Combined Therapy With Metformin and Hydroxypropyl-β-Cyclodextrin in a Mouse Model of Niemann-Pick Disease Type C1

Assessment of the Current State of Pharmacovigilance System in Pakistan Using Indicator-Based Assessment Tool

Development of IKATP Ion Channel Blockers Targeting Sulfonylurea Resistant Mutant KIR6.2 Based Channels for Treating DEND Syndrome

Editorial: Classical and Modern Biotechnology Applied to the Treatment of Epilepsy and Anxiety Disorders

The Arsenal of Bioactive Molecules in the Skin Secretion of Urodele Amphibians

Enhancing Choices Regarding the Administration of Insulin Among Patients With Diabetes Requiring Insulin Across Countries and Implications for Future Care

MicroRNA-92a-3p Enhances Cisplatin Resistance by Regulating Krüppel-Like Factor 4-Mediated Cell Apoptosis and Epithelial-to-Mesenchymal Transition in Cervical Cancer

Targeting HSP90 Inhibits Proliferation and Induces Apoptosis Through AKT1/ERK Pathway in Lung Cancer

A GSH/CB Dual-Controlled Self-Assembled Nanomedicine for High-Efficacy Doxorubicin-Resistant Breast Cancer Therapy

Comparative Effectiveness and Safety of Low-Dose Oral Anticoagulants in Patients With Atrial Fibrillation

Preclinical Evaluation of Dimethyl Itaconate Against Hepatocellular Carcinoma via Activation of the e/iNOS-Mediated NF-κB–Dependent Apoptotic Pathway

Gypenosides Attenuate Pulmonary Fibrosis by Inhibiting the AKT/mTOR/c-Myc Pathway

Platelet-Derived Growth Factor-BB Inhibits Intervertebral Disc Degeneration via Suppressing Pyroptosis and Activating the MAPK Signaling Pathway

Anti-Liver Fibrosis Activity and the Potential Mode of Action of Ruangan Granules: Integrated Network Pharmacology and Metabolomics

Repurposing Tranexamic Acid as an Anticancer Agent

COVID-19 and Periodontitis: A Dangerous Association?

Molecular Mechanisms of Epileptic Encephalopathy Caused by KCNMA1 Loss-of-Function Mutations

Interaction of Serum Alkaline Phosphatase and Folic Acid Treatment on Chronic Kidney Disease Progression in Treated Hypertensive Adults

Discovery of the Potential Novel Pharmacodynamic Substances From Zhi-Zi-Hou-Po Decoction Based on the Concept of Co-Decoction Reaction and Analysis Strategy

Cancer Chemoprevention: A Strategic Approach Using Phytochemicals

Safety Evaluation of Natural Drugs in Chronic Skeletal Disorders: A Literature Review of Clinical Trials in the Past 20 years

Amoxicillin Haptenation of α-Enolase is Modulated by Active Site Occupancy and Acetylation

Therapeutic Opportunities of GPBAR1 in Cholestatic Diseases

Discovery of Novel Reductive Elimination Pathway for 10-Hydroxywarfarin