Frontiers in Pharmacology

Original Research

Published on 10 Dec 2025

Optimisation of peptides targeting reverse transcriptase HIV-1 using QSAR, machine learning, and computational approaches

Fachrur Rizal Mahendra
Indira Prakoso
Alfa Marzelino
Muhamad Rizqy Fadhillah
Syukriyansyah
Muhammad Marsha Azzami Hasibuan
Juniza Firdha Suparningtyas
Mikael Kristiadi
Aprijal Ghiyas Setiawan
Faris Izzatur Rahman

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1707377

1,377 views

Original Research

Published on 10 Dec 2025

Potential lipid-lowering effects of preussin B on inhibition of intestinal cholesterol absorption: integrative mechanisms of action and proteomic analysis

Atcharaporn Ontawong
Jakkapong Inchai
Pannita Holasut
Wararat Chiangjong
Thaweesak Chieochansin
Davide Crucitti
Adrián Mosquera Orgueira
Worarat Rojanaverawong
Thanthakan Saithong
Kornwalai Tunkaew

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708213

743 views

Review

Published on 10 Dec 2025

Immune modulation in inflammatory bowel disease: therapeutic promise of baicalein

Yang Wang
Luyao Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1723606

882 views

Review

Accepted on 09 Dec 2025

Molecular insights into NLRP3 inflammasome and miRNA modulation in oral cancer

Deborah Mannino
Morena D'Ariano
Ivana Bello
Irene Paterniti
Giovanna Casili
Elisabetta Panza

Frontiers in Pharmacology

243 views

Original Research

Accepted on 09 Dec 2025

Comparison of Granule and Traditional Decoction of Gancao Xiexin for Cold-Heat Complex Pattern Recurrent Oral Ulcer: A Randomized Controlled Trial

Si-Run Liu
Hai-Tao Zhu
佩琦陈
Yu -Yu Zeng
Rui-Min Wang
Huachong Xu
Zejian Li

Frontiers in Pharmacology

324 views

Systematic Review

Accepted on 09 Dec 2025

Pediatric Efficacy and Safety in Common Cold Treated with Herbal Medicine (PEACH): A Systematic Review and Meta-Analysis

Soo-Dam Kim
Su Won Lee
Seong-Cheon Woo
Dong-Hyeon Kim
Lee Keon Jun
Jong-Hee Kim
Dong-Yeol Yang
Byoung-Kab Kang
Yang-Chun Park
Boram Lee

Frontiers in Pharmacology

199 views

Original Research

Accepted on 09 Dec 2025

Multi-omics characterization of RNF157 expression patterns in hepatocellular carcinoma and development of an RNF157-associated prognostic signature

Qingsong Yang
Meng Zhang
Chang-song Ma
Ao Li
Wenjun Zhang

Frontiers in Pharmacology

123 views

Original Research

Accepted on 09 Dec 2025

Prediction of prognosis and immunotherapy response of tryptophan metabolism genes in acute myeloid leukemia

Tantan Zhong
Meirui Zhang
Xinran Qi
Zhihui Qi
Peipei Li
Na Wang
Xianghua Wang
Panpan Feng
Xiaosheng Fang

Frontiers in Pharmacology

172 views

Review

Accepted on 09 Dec 2025

Genome-wide Association Studies and Traditional Chinese Medicine in Hyperuricemia: Current Evidence and Mechanistic Insights

Le Yang
Jing Liu
Shengping Luo
Yihui Deng

Frontiers in Pharmacology

103 views

Systematic Review

Accepted on 09 Dec 2025

An evidence-based meta-analysis on the use of Brivaracetam in treating seizures in real-world clinical practice

Yu Zhang
Liu Huihui
Wang Xin
Zhao Zhiqiang
Su Hong
Ma Yanjun
Zhao Jie
Qingshan Wang
Liyan Hou

Frontiers in Pharmacology

132 views

Original Research

Accepted on 09 Dec 2025

Sacubitril/Valsartan Fails to Prevent Doxorubicin-Induced Cognitive Impairment and Hippocampal Oxidative, Inflammatory, and Apoptotic Alterations in Rats

Mohrah Muteb Alresheedi
Maha Aldubayan

Frontiers in Pharmacology

Original Research

Accepted on 09 Dec 2025

Berberine Suppresses Hepatocellular Carcinoma Progression by Blocking IL-4-JAK1-STAT6-mediated M2 Polarization of Macrophage

Wang Peng
Yuwen Zhong
Mengkai Li
Weiyi Jiang
Mnegqi Zhuang
Xuecheng Ge
Huixing Li
Yaoshuai Zhang
Yu Qiao
Jiayao Jiang

Frontiers in Pharmacology

301 views

Review

Accepted on 09 Dec 2025

Targeting CD73 and correcting adenosinergic signaling in critically ill patients

Justin Lunderberg
Alexander James Spicer
Jessica Cassavaugh
Juho Jalkanen
George Hasko
Simon C Robson

Frontiers in Pharmacology

142 views

Editorial

Published on 09 Dec 2025

Editorial: Innovative approaches for wound treatment

Junxiao Zhang
Shenglin Geng
Guojuan Fan
Jinlong Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1738213

389 views

Review

Published on 09 Dec 2025

Pharmacological effects and application prospects of mussel adhesive proteins

Junsha An
Zengmiao Hou
Jiaqi Li
Qian Bi
Shile Huang
Cheng Peng
Fu Peng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1704475

722 views

Original Research

Published on 09 Dec 2025

Protective effects of an Fc-engineered PD-L1 fusion protein in a spontaneous abortion model and a Th17 cell–induced pregnancy loss model

Guangyao Li
Tiantian Wang
Dan Tan
Yamin Jin
Xuemei Zhou
Hongru Ai
Xinya Zheng
Xiaochen Ren
Shi Hu
Changhai Lei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1703805

446 views

Original Research

Published on 09 Dec 2025

Pharmacokinetics and pharmacodynamics of cannabigerol (CBG) in the C57BL/6Crl mouse

Ayat Zagzoog
Kenzie Halter
Nini Ha
Alayna M. Jones
Rachel Andres
Andy Kim
Deborah Michel
Jane Alcorn
Robert B. Laprairie

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1672098

1,024 views

Original Research

Published on 09 Dec 2025

Impact of different doses of rivaroxaban on clinical outcomes in elderly patients with non-valvular atrial fibrillation: a real-world study

Juan Yu
Zufeng Zhang
Qingru Yuan
Haobing Hu
Huimin Li
Meifang Huang
Youlin Mao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714318

599 views

Systematic Review

Published on 09 Dec 2025

Is tranexamic acid effective for all traumatic brain injury patients? a severity based systematic review and meta-analysis

Wentao Bian
Mengxia Qi
Lu Ding
Yixuan Lu
Kangling Yan
Ziqi Wang
Jiancheng Zhang
Ping Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1677936

676 views

Original Research

Published on 09 Dec 2025

Phoxim induces neurotoxicity and intestinal damage in Caenorhabditis elegans

Mengyuan Zhang
Xin Zhao
Hua Bai
Qi Wang
Wei Zou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657527

735 views

Conceptual Analysis

Published on 09 Dec 2025

The night is dark and full of hesitation. The latest step in the legal trajectory of assisted suicide in Italy: through tentative judicial openings, bioethical contradictions and the Parliament’s deafness

Paola Frati
Marco Albore
Eleonora Micaela Ertola
Sossio Del Prete
Letizia Sorace
Raffaele La Russa
Giorgio Bolino

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1520136

522 views

Original Research

Published on 09 Dec 2025

Disrupting cell death: ferroptosis and pyroptosis inhibition in hepatic ischemia-reperfusion injury via modulation of GPX4 and cGAS pathways by deferoxamine and octreotide

Rasha A. Tawfiq
Yasmeen M. Attia
Hameis M. Sleem
Mai El-Sayed Ghoneim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610718

797 views

Original Research

Published on 09 Dec 2025

Ethnobotany, chemical analysis, and antiglycation activity of Elsholtzia species from Northern Thailand

Angkhana Inta
Pitchaya Mungkornasawakul
Lalida Shank
Wittaya Pongamornkul
Yinxian Shi
Yao Fu
Ruyu Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673250

494 views

Original Research

Published on 09 Dec 2025

Cryptotanshinone targets tumor-immune-microbiome axis to suppress colorectal cancer

Zhenya Yang
Mengting Zhou
Fenglin Luo
Shiqi Feng
Yu Tan
Qiqian Wang
Zeneng Cheng
Ruirong Tan
Rui Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667500

872 views

29,106 Publications

volumes

Volume 16 - 2025

Optimisation of peptides targeting reverse transcriptase HIV-1 using QSAR, machine learning, and computational approaches

Potential lipid-lowering effects of preussin B on inhibition of intestinal cholesterol absorption: integrative mechanisms of action and proteomic analysis

Immune modulation in inflammatory bowel disease: therapeutic promise of baicalein

Molecular insights into NLRP3 inflammasome and miRNA modulation in oral cancer

Comparison of Granule and Traditional Decoction of Gancao Xiexin for Cold-Heat Complex Pattern Recurrent Oral Ulcer: A Randomized Controlled Trial

Pediatric Efficacy and Safety in Common Cold Treated with Herbal Medicine (PEACH): A Systematic Review and Meta-Analysis

Multi-omics characterization of RNF157 expression patterns in hepatocellular carcinoma and development of an RNF157-associated prognostic signature

Prediction of prognosis and immunotherapy response of tryptophan metabolism genes in acute myeloid leukemia

Genome-wide Association Studies and Traditional Chinese Medicine in Hyperuricemia: Current Evidence and Mechanistic Insights

An evidence-based meta-analysis on the use of Brivaracetam in treating seizures in real-world clinical practice

Sacubitril/Valsartan Fails to Prevent Doxorubicin-Induced Cognitive Impairment and Hippocampal Oxidative, Inflammatory, and Apoptotic Alterations in Rats

Berberine Suppresses Hepatocellular Carcinoma Progression by Blocking IL-4-JAK1-STAT6-mediated M2 Polarization of Macrophage

Targeting CD73 and correcting adenosinergic signaling in critically ill patients

Editorial: Innovative approaches for wound treatment

Pharmacological effects and application prospects of mussel adhesive proteins

Protective effects of an Fc-engineered PD-L1 fusion protein in a spontaneous abortion model and a Th17 cell–induced pregnancy loss model

Pharmacokinetics and pharmacodynamics of cannabigerol (CBG) in the C57BL/6Crl mouse

Impact of different doses of rivaroxaban on clinical outcomes in elderly patients with non-valvular atrial fibrillation: a real-world study

Is tranexamic acid effective for all traumatic brain injury patients? a severity based systematic review and meta-analysis

Phoxim induces neurotoxicity and intestinal damage in Caenorhabditis elegans

The night is dark and full of hesitation. The latest step in the legal trajectory of assisted suicide in Italy: through tentative judicial openings, bioethical contradictions and the Parliament’s deafness

Disrupting cell death: ferroptosis and pyroptosis inhibition in hepatic ischemia-reperfusion injury via modulation of GPX4 and cGAS pathways by deferoxamine and octreotide

Ethnobotany, chemical analysis, and antiglycation activity of Elsholtzia species from Northern Thailand

Cryptotanshinone targets tumor-immune-microbiome axis to suppress colorectal cancer