Frontiers in Pharmacology

Review

Published on 12 Jan 2026

Exploring cannabinoid modulation on autophagy mechanisms in Alzheimer’s disease: a review

C. Ntsapi
M. Weyers
R. Chinheya
T. Jim
M. Matsabisa

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1748368

1,070 views

Original Research

Published on 12 Jan 2026

Tumor-derived extracellular vesicles mediate cell-specific uptake and facilitate enhanced doxorubicin delivery in breast cancer

Dhananjay B. Alagundagi
Mahima Rachel Thomas
Vinay C. Sangamesh
Vinay Kumar J Rajendra
Vijith V. Shetty
Shama Prasada Kabekkodu
Praveenkumar Shetty
Prakash Patil

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1744895

871 views

Review

Published on 12 Jan 2026

Cycloastragenol in inflammation-related diseases: mechanisms, pharmacokinetics, and translational prospects

Chun Zhao
Xiuhua Yang
Man Yao
Xiaoxuan Song
Jingtong Dai
Pilong He

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1732996

1,019 views

Original Research

Published on 12 Jan 2026

Setmelanotide-mediated MC4R activation improves hypothalamic obesity via CaMKK2/AMPK pathways

Junjie Peng
Yichao Ou
Mingfeng Zhou
Xingqin Wang
Xi’an Zhang
Hao Long
Guangsen Wu
Mengjie Che
Kai Li
Le Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1730786

1,269 views

Review

Published on 12 Jan 2026

Probucol: revisiting as a multifaceted therapeutic agent in atherosclerosis

Sha Li
Hui-Hui Liu
Rui-Xia Xu
Jian-Jun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1704983

1,257 views

Original Research

Published on 12 Jan 2026

Association of genetically instrumented HMGCR inhibition with the therapeutic role of prostate cancer: a Mendelian randomization study and supporting in vitro experiments

Xiaojie Hao
Jingjun Mu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701869

642 views

Original Research

Published on 12 Jan 2026

Clinical outcomes of adverse drug reaction-related hospital admissions in older adults with diabetes

Azizah Vonna
Mohammed S. Salahudeen
Gregory M. Peterson

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1729848

622 views
1 citation

Original Research

Published on 12 Jan 2026

Dual blockade of DPP-4 and CXCL12/CXCR4 axes synergistically protects podocytes in lupus nephritis

Hui-miao Hu
Yong-chun Li
Yang-ming Zhang
Teng-yu Zhu
Wei-jing Yong
Yu-hui Gan
Chen Liu
Rui-ying Duan
Hong-de Xu
Zhan-zheng Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1732243

994 views

Systematic Review

Published on 12 Jan 2026

Efficacy and safety of opioid-receptor antagonists for opioid-induced constipation: a systematic review and meta-analysis

Yuanlin Li
Yuyuan Tu
Zihao Zhou
Defu Liao
Ziyan He
Yan Li
Boyu Li
Zhiren Liu
Zugang Zhou
Shuangchun Ai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1749875

1,013 views

Original Research

Published on 12 Jan 2026

Computational-experimental integration identifies potent carbohydrate-hydrolyzing enzyme inhibitors from Nardostachys jatamansi: molecular docking, dynamics and pharmacokinetic predictions

Muhammad Javid Iqbal
Iqra Malik
Gonzalo Bernal
Alexis M. Salas-Burgos
Luis A. Salazar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1713452

991 views

Review

Published on 12 Jan 2026

Protective effects of naringenin and naringin in organ ischemia/reperfusion injuries: a comprehensive narrative review

Min Hou
Daiyan Wei
Yanshun Wang
Xiaojian Zhang
Zhiwei Yao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701726

1,140 views

Original Research

Published on 12 Jan 2026

Assessment of the acute toxicity of ethanol extract from the rhizomes of Iris scariosa L. in mice

Ailazzat A. Aitkenova
Gayane A. Atazhanova
Karakoz Zh. Badekova
Aleksandr V. Samorodov
Saule B. Akhmetova
Margarita Yu. Ishmuratova
Islambek Karilkhan
Arailym A. Tazhina
Ainur Zh. Sydykova

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701980

813 views

Review

Published on 12 Jan 2026

Bioactive metabolites of botanical drugs in the treatment of intervertebral disc degeneration-a review of promising therapeutic candidate

Le Qi
Xinming Fan
Jiabing Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1700077

673 views

Original Research

Published on 12 Jan 2026

Naeso-san, a traditional herbal formula, attenuates HCl/ethanol-induced gastric injury via MAPK and NF-κB pathway modulation in mice

Suji Choi
In Gyoung Ju
Minji Lee
Seungmin Lee
Minsik Choi
Seong Hye Kim
Seong-Hoon Park
Hyangsook Lee
Young Pyo Jang
Eugene Huh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1672854

885 views

Original Research

Published on 12 Jan 2026

Development of an in vitro metabolic dysfunction-associated steatohepatitis model to investigate altered drug metabolizing enzymes, transport proteins, and hepatobiliary disposition

William A. Murphy
Sarina Kyburz
Henry Ho
Matthew Shane Loop
John K. Fallon
Jacqueline B. Tiley
Thomas Kralj
Kim L. R. Brouwer

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1664808

1,342 views

Original Research

Published on 12 Jan 2026

Cinnamomum verum extract as a potential therapeutic for atopic dermatitis through reducing lipid peroxidation and oxidative stress

Min Jung Kim
Mi Jin Jang
Ju-Hye Yang
Young Zoo You
Ye Jin Yang
Ji Woong Heo
Han Nim Choi
Ryounghoon Jeon
Sang-Hyun An
Kwang Il Park

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714816

732 views

Original Research

Published on 12 Jan 2026

The role of total polysaccharides from Sonchus arvensis L. in the prevention and treatment of colitis via regulation of gut microbiota and metabolites

Yachao Ren
Shenghua Hou
Guoyou Chen
Yulong Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657918

464 views

Review

Published on 12 Jan 2026

Tribulus terrestris L.: a medicinal plant with promising therapeutic potential for skin diseases

Xiao-Mu Wang
Xiao-Min Liu
Yan Zeng
Ke-Jing Zhu
Tian-Tian Shen
Fang Bian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1732016

1,211 views

Original Research

Published on 12 Jan 2026

Bromhexine inhibits SARS-CoV-2 Omicron and variant pseudovirus infection via ACE2-targeted mechanisms

Rafael Zúñiga
Whitney Venturini
Natalia González
Paulina Valenzuela-Hormazábal
Laura Sánchez-Aros
David Ramírez
Angel Cayo
Cristian Vilos
Leandro Zúñiga

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1745277

1,067 views

Review

Published on 12 Jan 2026

Metabolite and gut microbiota co-biomarkers in Danggui Shaoyao San: insights into a shared therapeutic approach

Xin Fu
Dinghan Peng
Yang Yu
Mingguo Cao
Xin Zheng
Songquan Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1698734

904 views

Original Research

Published on 12 Jan 2026

Antioxidant, antiaging and mitochondrial protective effects of JadeAging in Caenorhabditis elegans

Bowen Lu
Dongli Yin
Jiahao Zhang
Yilei Wang
Xue Wang
Shengcan Zou
Jiacheng Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1644921

890 views

Review

Published on 12 Jan 2026

Bile acids as therapeutic agents

Brandon Vu
Ryo Kawamoto
Priscila Villalba-Davila
Xinzhong Dong
Wikrom Karnsakul

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1732854

1,640 views

Original Research

Published on 12 Jan 2026

Serum valeric acid stimulates lung epithelial cilia assembly and improves prognosis in patients with severe respiratory infections

Yabin Zhang
Yuqing Zhang
Lin Wang
Beibei Liu
Jiajia Zheng
Jiabao Cao
Lixin Xie
Ning Shen
Jun Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1761517

1,058 views

29,525 Publications

volumes

Volume 16 - 2025

Exploring cannabinoid modulation on autophagy mechanisms in Alzheimer’s disease: a review

Tumor-derived extracellular vesicles mediate cell-specific uptake and facilitate enhanced doxorubicin delivery in breast cancer

Cycloastragenol in inflammation-related diseases: mechanisms, pharmacokinetics, and translational prospects

Setmelanotide-mediated MC4R activation improves hypothalamic obesity via CaMKK2/AMPK pathways

Probucol: revisiting as a multifaceted therapeutic agent in atherosclerosis

Association of genetically instrumented HMGCR inhibition with the therapeutic role of prostate cancer: a Mendelian randomization study and supporting in vitro experiments

Clinical outcomes of adverse drug reaction-related hospital admissions in older adults with diabetes

Dual blockade of DPP-4 and CXCL12/CXCR4 axes synergistically protects podocytes in lupus nephritis

Efficacy and safety of opioid-receptor antagonists for opioid-induced constipation: a systematic review and meta-analysis

Computational-experimental integration identifies potent carbohydrate-hydrolyzing enzyme inhibitors from Nardostachys jatamansi: molecular docking, dynamics and pharmacokinetic predictions

Protective effects of naringenin and naringin in organ ischemia/reperfusion injuries: a comprehensive narrative review

Assessment of the acute toxicity of ethanol extract from the rhizomes of Iris scariosa L. in mice

Bioactive metabolites of botanical drugs in the treatment of intervertebral disc degeneration-a review of promising therapeutic candidate

Naeso-san, a traditional herbal formula, attenuates HCl/ethanol-induced gastric injury via MAPK and NF-κB pathway modulation in mice

Development of an in vitro metabolic dysfunction-associated steatohepatitis model to investigate altered drug metabolizing enzymes, transport proteins, and hepatobiliary disposition

Cinnamomum verum extract as a potential therapeutic for atopic dermatitis through reducing lipid peroxidation and oxidative stress

The role of total polysaccharides from Sonchus arvensis L. in the prevention and treatment of colitis via regulation of gut microbiota and metabolites

Tribulus terrestris L.: a medicinal plant with promising therapeutic potential for skin diseases

Bromhexine inhibits SARS-CoV-2 Omicron and variant pseudovirus infection via ACE2-targeted mechanisms

Metabolite and gut microbiota co-biomarkers in Danggui Shaoyao San: insights into a shared therapeutic approach

Antioxidant, antiaging and mitochondrial protective effects of JadeAging in Caenorhabditis elegans

Bile acids as therapeutic agents

Serum valeric acid stimulates lung epithelial cilia assembly and improves prognosis in patients with severe respiratory infections

Volume 17 - 2026

Prevalence and risk factors of burnout among community pharmacists in the Aseer region, Saudi Arabia: a cross-sectional study