Frontiers in Pharmacology

Systematic Review

Published on 05 Jan 2026

Effectiveness of drug-loaded poly(ethylene glycol) and poly(lactic-co-glycolic-acid) nanoparticles in the in vitro treatment of breast cancer: a systematic review

Cristian Sandoval-Vásquez
Isabella Cárcamo
Paula Lagos
Anaís Muñoz
Francisco Zavala
Valentina Colil
Francisca Villagrán-Silva
Edgar Vásquez-Carrasco
Jordan Hernandez-Martinez
Pablo Valdés-Badilla

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710176

1,094 views

Original Research

Published on 05 Jan 2026

Randomized trial and multi-omics, machine learning–based mechanistic exploration of daixie decoction granules in type 2 diabetes

Zhong Zheng
Kepei Zhang
Xiaogang Ma
Yuezhou Qian
Miao Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1723584

1,028 views

Original Research

Published on 05 Jan 2026

Wound healing and photodynamic potential of Adiantum capillus-veneris L. (Pteridaceae): an evaluation of the cellular effects and molecular insights

Linru Mou
Banaz Jalil
Francesca Scotti
Majella E. Lane
Bernd L. Fiebich
Lu Sun
Caroline Maake
Michael Heinrich

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1729572

939 views

Original Research

Published on 05 Jan 2026

Natural product extracts for ischemic stroke: a methodological evaluation and meta-epidemiological analysis

Sijin Wang
Minghui Zhang
Yao Lu
Peipei Du
Ziwen Xu
Xu Pang
Jierong Gao
Li Li
Chi Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1730699

927 views

Original Research

Published on 02 Jan 2026

Donkey milk-derived exosomes protect against UVB irradiation-induced ferroptosis in skin cells: in vitro and in vivo evidence

Jie Yu
Jie Cheng
Guangyuan Liu
Zhijie Cheng
Pengxiang Niu
Derui Xu
Xinyun Pei
Hang Tie
Cong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683253

944 views

Original Research

Published on 02 Jan 2026

Patterns of prescription, over-the-counter, and herbal medication use among pregnant women in Buraydah, Saudi Arabia: a cross-sectional study

Masaad S. Almutairi
Mustafa S. Saeed
Hessa Alowias
Afnan Alharbi
Faris S. Alnezary
Omar A. Almohammed

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1732619

944 views

Systematic Review

Published on 02 Jan 2026

The potential role of GLP-1 receptor agonists in substance use disorders – a systematic review

K. M. Völker
B. L. H. Prechtl
N. L. Bormann
D. S. Choi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702448

2,330 views

Review

Published on 02 Jan 2026

System Xc-pathway as a potential regulatory target in neurological disorders

Ying Chen
Wei Xiao
Chengli Qian
Linshu Huang
Jianghao Lv
Zhuo Wang
Yi Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701320

1,438 views

Original Research

Published on 02 Jan 2026

A cost-effectiveness analysis of baloxavir marboxil versus oseltamivir for seasonal influenza treatment in China

Fangyu Zheng
Yuekun Tang
Hongli Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697645

1,044 views

Original Research

Published on 02 Jan 2026

Spectrum mining of immune checkpoint inhibitor-related cutaneous toxicities and analysis of associated factors based on FAERS

Siyao Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1684390

1,429 views

Systematic Review

Published on 02 Jan 2026

A network meta-analysis of first-line treatment options for patients with Child-Pugh class B functional hepatocellular carcinoma: comparison of efficacy and safety

Yu-Xuan Zhang
Jia-Yi Wu
Jun-Yi Wu
Zhen-Xin Zeng
Rong-Jian Pan
Xiang-Ye Ou
Yi-Nan Li
Mao-Lin Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1705502

1,384 views

Original Research

Published on 02 Jan 2026

Cedrol ameliorates inflammatory bowel disease via mitochondrial biogenesis, gut microbiota restoration, and intestinal barrier repair

Mo-Rong Xu
Chia-Hsin Lin
Chung-Hsuan Wang
Sheng-Yang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1619537

1,085 views

Correction

Published on 02 Jan 2026

Correction: Nafamostat mesilate attenuates renal fibrosis by suppressing the IL-17 signaling pathway

Weili Liao
Rui Fan
Yuman Du
Hairong Wang
Yong Yang
Yuan Tian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1764700

565 views

Original Research

Published on 02 Jan 2026

Bone-targeted mitochondrial delivery via magnetic-temperature responsive artificial cells for repairing age-related fractures

Shihao Nie
Yue Yu
Rong Yan
Taoran Liu
Yue Du
Zhuojing Luo
Shengyou Li
Jinghui Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1725973

1,368 views

Original Research

Published on 02 Jan 2026

Neoantigen immune responses in healthy volunteers: insights from multiple integrated keyhole limpet hemocyanin challenge studies on repeated immunization and response covariates

Micha N. Ronner
Marieke L. De Kam
Silke Van Reeuwijk
Jacobus Burggraaf
Manon A. A. Jansen
Matthijs Moerland

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1717333

985 views

Original Research

Published on 02 Jan 2026

Ferula ammoniacum gum aqueous extract exerts anti-inflammatory and antioxidant mechanisms to combat aluminum chloride-induced Alzheimer’s disease in rats: possible involvement of opioid pathways

Sajad Fakhri
Mohammad Mehdi Gravandi
Mohammad Bagher Majnooni
Mohammad Hosein Farzaei
Fatemeh Abbaszadeh
Khodabakhsh Rashidi
Javier Echeverría

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1708643

973 views

Original Research

Published on 02 Jan 2026

Jaranol: a compound with therapeutic activity against pathological cardiac remodelling via multi-target inhibition of the Snai3/TLR2 and NF-κB signaling pathways

Yao Zhang
Nan Li
Shiqi Chu
Heqing Fu
Xiaowen Yang
Huimin Xia
Yunfeng Xiao
Zhibin Xiao
Jing Liu
Yu Dong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1723889

846 views

Systematic Review

Published on 02 Jan 2026

Efficacy and safety of Chinese herbal medicine for metabolic conditions: a systematic review and meta-analysis of randomised controlled trials

Yinglin Liang
Hongshen Yu
Jie Ren
Jiayi Ren
Guanlin Chen
Yikai Zhang
Yefeng Cai
Xiaojia Ni

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1644950

1,616 views

Systematic Review

Published on 02 Jan 2026

Effects of modified Soyo-san (Xiao-yao-san, Shoyo-san) combined with antidepressants on post-stroke depression and functional recovery: a systematic review and meta-analysis

Jeongrim Bak
Hyowon Jin
Jong-Min Yun
Jungtae Leem

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651831

963 views

Mini Review

Published on 02 Jan 2026

Tumor-like characteristics of vascular smooth muscle cells in atherosclerosis

Xiangchun Li
Yuyan Deng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1734123

929 views

Review

Published on 02 Jan 2026

Evidence-based production framework for herbal medicine regulation in Indonesia

Mohamad Kashuri
Taruna Ikrar
Sutriyo
Abdul Mun’im
Arry Yanuar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1730273

1,455 views

Review

Accepted on 30 Dec 2025

Pharmacological Advances in Multi-Targeted Strategies for Type 2 Diabetes Mellitus: A Systematic Perspective Based on Traditional Chinese Medicine

Yanli Zhao
Jiabao Liao
Panpan Pang
JingYuan Li
Suocai Su
Mengqiu Shao
Weibo Wen
Furong Xu

Frontiers in Pharmacology

257 views

Review

Accepted on 24 Dec 2025

MOLECULAR AND PATHOPHYSIOLOGICAL INTERSECTIONS BETWEEN ARTERIAL HYPERTENSION, PULMONARY INFLAMMATION AND DIABETES MELLITUS

Higo José Neri da Silva
Antônio Carlos Melo Lima Filho
Ester Miranda Pereira
Ian Jhemes Oliveira Sousa
Francisco Valmor Macedo Cunha
Massimo Lucarini
Alessandra Durazzo
Leonardo da Rocha Sousa
Daniel Dias Rufino Arcanjo

Frontiers in Pharmacology

204 views

29,545 Publications

volumes

Volume 16 - 2025

Effectiveness of drug-loaded poly(ethylene glycol) and poly(lactic-co-glycolic-acid) nanoparticles in the in vitro treatment of breast cancer: a systematic review

Randomized trial and multi-omics, machine learning–based mechanistic exploration of daixie decoction granules in type 2 diabetes

Wound healing and photodynamic potential of Adiantum capillus-veneris L. (Pteridaceae): an evaluation of the cellular effects and molecular insights

Natural product extracts for ischemic stroke: a methodological evaluation and meta-epidemiological analysis

Donkey milk-derived exosomes protect against UVB irradiation-induced ferroptosis in skin cells: in vitro and in vivo evidence

Patterns of prescription, over-the-counter, and herbal medication use among pregnant women in Buraydah, Saudi Arabia: a cross-sectional study

The potential role of GLP-1 receptor agonists in substance use disorders – a systematic review

System Xc-pathway as a potential regulatory target in neurological disorders

A cost-effectiveness analysis of baloxavir marboxil versus oseltamivir for seasonal influenza treatment in China

Spectrum mining of immune checkpoint inhibitor-related cutaneous toxicities and analysis of associated factors based on FAERS

A network meta-analysis of first-line treatment options for patients with Child-Pugh class B functional hepatocellular carcinoma: comparison of efficacy and safety

Cedrol ameliorates inflammatory bowel disease via mitochondrial biogenesis, gut microbiota restoration, and intestinal barrier repair

Correction: Nafamostat mesilate attenuates renal fibrosis by suppressing the IL-17 signaling pathway

Bone-targeted mitochondrial delivery via magnetic-temperature responsive artificial cells for repairing age-related fractures

Neoantigen immune responses in healthy volunteers: insights from multiple integrated keyhole limpet hemocyanin challenge studies on repeated immunization and response covariates

Ferula ammoniacum gum aqueous extract exerts anti-inflammatory and antioxidant mechanisms to combat aluminum chloride-induced Alzheimer’s disease in rats: possible involvement of opioid pathways

Jaranol: a compound with therapeutic activity against pathological cardiac remodelling via multi-target inhibition of the Snai3/TLR2 and NF-κB signaling pathways

Efficacy and safety of Chinese herbal medicine for metabolic conditions: a systematic review and meta-analysis of randomised controlled trials

Effects of modified Soyo-san (Xiao-yao-san, Shoyo-san) combined with antidepressants on post-stroke depression and functional recovery: a systematic review and meta-analysis

Tumor-like characteristics of vascular smooth muscle cells in atherosclerosis

Evidence-based production framework for herbal medicine regulation in Indonesia

Pharmacological Advances in Multi-Targeted Strategies for Type 2 Diabetes Mellitus: A Systematic Perspective Based on Traditional Chinese Medicine

MOLECULAR AND PATHOPHYSIOLOGICAL INTERSECTIONS BETWEEN ARTERIAL HYPERTENSION, PULMONARY INFLAMMATION AND DIABETES MELLITUS

Volume 17 - 2026

Tripterine from Tripterygium wilfordii exosome accelerated diabetic wound healing by improving endothelial cell function