Frontiers in Pharmacology

Original Research

Published on 18 Dec 2025

A warming-yang herbal decoction protects against high-altitude hypoxia–induced osteoblast injury through modulation of HIF-1 signaling

Xuehai Liu
Yaqian Qi
Rui Zhao
Binkui Jia
Xilin Lei
Hongfan Li
Di Wang
Haoling Zhang
Wei Wang
Zhijing Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673146

1,221 views

Systematic Review

Published on 18 Dec 2025

Synergistic antitumor effects of astragalus polysaccharide: a preclinical systematic review and meta-analysis

Ruo Zhang
Qian Yang
Zhi Chen
Jianming Huang
Guonan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1672450

1,628 views

Original Research

Published on 18 Dec 2025

Inflammatory response in CF airway epithelial cells: a comparative study of modulators and wild-type CFTR rescue

Amal Kouadri
Camille Lyko
Carine El Hajjar
Johanna Cormenier
Kevin Kevin Gemy
Nadia Alfaidy
Mohamed Benharouga

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657688

937 views

Original Research

Published on 18 Dec 2025

Identification of novel therapeutic targets and effective anticancer agents for gallbladder cancer by integrating bioinformatics analysis and experimental validation

Yanjie Zhong
Ruiqi Zou
Ximei Luo
Siqi Yang
Zhiqiang He
Haijie Hu
Fuyu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1658462

1,316 views

Original Research

Published on 18 Dec 2025

Therapeutic trough mycophenolic acid levels positively correlate with omega-3 fatty acids in leukocytes of children with idiopathic nephrotic syndrome. a pilot study

Stefano Turolo
Alberto Edefonti
Marie-Louise Syren
Anita S. Bellotti
William Morello
Federica Collino
Carlo Agostoni
Giovanni Montini

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1672304

1,150 views

Original Research

Published on 18 Dec 2025

Nonclinical evaluation of HS630, a proposed biosimilar of trastuzumab emtansine: affinity, pharmacokinetics, and immunogenicity

Hui Jiang
Jinjing Che

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1698727

1,356 views

Original Research

Published on 18 Dec 2025

Mitophagy-related gene TRIP13 predicts prognosis and immune response and promotes proliferation and migration in vitro and in vivo of clear cell renal cell carcinoma

Zhongjun Jiang
Lanlan Wang
Zhongrun He
Lian Guo
Wen Luo
Ying Fu
Qiyu Xiao
Guanglan Chen
Yinzi Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1736086

901 views

Opinion

Published on 18 Dec 2025

Voriconazole injection use in patients receiving continuous renal replacement therapy

Ling Zhou
Zhenwei Yu
Xia Wang
Huaiyu Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1736767

978 views

Clinical Trial

Published on 18 Dec 2025

Pharmacokinetics and safety of the antitumor drug everolimus in healthy Chinese subjects: a single-dose, open-label, randomized, two-sequence, two-period crossover, phase I bioequivalence study

Xiaodan Chen
Xiaoyi Yi
Yuting Liu
Xiaosong Wang
Yahui Peng
Qiong Wang
Ying Shuai
Hong Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1718032

876 views

Original Research

Published on 18 Dec 2025

Differential effects of PCSK9 inhibitors and statins on plasma ceramides in coronary artery disease

Liang Zhang
Yaodong Ding
Yong Zeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1726925

1,156 views

Mini Review

Published on 18 Dec 2025

Intranasal delivery of iron chelators and management of central nervous system disease

Ruiying Cheng
Jonghan Kim

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1709259

1,488 views

Review

Published on 18 Dec 2025

Molecular mechanisms and multi-target therapeutic strategies of diabetic nephropathy: from pathogenesis to precision interventions

Jiahuan Gong
Xingxing Fang
Xinlei Yao
Fei Xue
Guangdong Qi
Bingqian Chen
Hualin Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1729941

2,011 views

Original Research

Published on 18 Dec 2025

Harnessing natural terpenes via PEGylated mucoadhesive vesicles for improved urinary bladder delivery: from in vitro evaluation to in vivo assessment

Hayder A. Hammoodi
Rofida Albash
Mohammed I. A. Hamed
Khaled M. Darwish
Amira B. Kassem
Asmaa Saleh
Jawaher Abdullah Alamoudi
Noha M. Badawi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1685423

763 views

Original Research

Published on 18 Dec 2025

Anti-inflammatory effect of a pimarane diterpenoid isolated from Nepeta adenophyta Hedge based on a network analysis approach and experimental assessment

Wei Zhao
Meng Li
Chuanqing Jia
Iftikhar Ali
Long Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1652902

1,151 views

Original Research

Accepted on 17 Dec 2025

Benefit-risk Assessment of the use of toxic botanical drugs in superiority field: A case study on Aconitum carmichaeli Debx

Xiaomeng Zhang
Bing Zhang
Jintao Lyv
Zhijian Lin
Xinlong Liu

Frontiers in Pharmacology

161 views

Systematic Review

Accepted on 17 Dec 2025

Efficacy and safety of efruxifermin for patients with NASH/MASH:an updated systematic review and meta-analysis

Yajun Xiao
Xue-Ping Liu
Yan-Ling Zhang
Xiao-Li Tian
Yan-Qun Liu
Yan Cheng
Cunliang Deng
Hao Sun

Frontiers in Pharmacology

274 views

Original Research

Published on 17 Dec 2025

The mechanistic role of gitogenin as a treatment for laryngeal cancer: a network pharmacology and experimental analysis

Zhuo Fu
Yue Guan
Zhangwei Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1663323

1,010 views

Original Research

Published on 17 Dec 2025

Study on mechanism of action of β-elemene in inhibiting cisplatin resistance in lung cancer through LncRNA LINC00511

Xiaoli Deng
Chunjie Hu
Lin Li
Guixian Yang
Chikun Li
Wanxun Zhang
Guangyu Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586657

995 views

Original Research

Published on 17 Dec 2025

Rapid health technology assessment of six non-ergot dopamine-receptor agonists for the treatment of early Parkinson’s disease

Jieqiong Lv
Hongbo Fu
Yanqiong Zhou
Wenwei Li
Jiaxin Zhang
Zhihua Zhou
Sha Lai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1648833

1,330 views

Review

Published on 17 Dec 2025

Novel protein acylations in ferroptosis: decoding the regulatory roles of lactylation, crotonylation, succinylation, and β-hydroxybutyrylation

Meiquan Wei
Shiming Wei
Xuhua Xie
Taotao Liu
Jun Deng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688548

2,137 views

Review

Published on 17 Dec 2025

Research progress on the regulatory effects and mechanisms of natural active products on intestinal barrier function

Fuyixuan Zheng
Yuemei Sun
Minghui Zhao
Rong Wang
Wenbin Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673568

1,218 views

Review

Accepted on 16 Dec 2025

Harnessing Curcumin in Oral Medicine: Mechanisms, Therapeutic Potential, and Future Innovations

Chengchen Hu
Shengguo Wang
Zhi Gao
Maofeng Qing
Lian Tan
Lu Yang
Fang Li

Frontiers in Pharmacology

430 views

Original Research

Published on 16 Dec 2025

Fedratinib reveals chemotherapeutic potential in esophageal squamous cell cancer

Man Luo
Jiang Zhu
Yong Yang
Chongbo Liao
Xiao Liu
Maoju Tang
Lei Xu
Xiaowu Zhong
Qiang Ma
Xiaolan Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1689663

1,329 views

Original Research

Published on 16 Dec 2025

O-GlcNAcylation of eNOS in high-salt-induced thoracic aorta endothelial dysfunction in mice

Chang Li
Liuming Gao
Yi Ling
Zhan Lv

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1730447

1,090 views

29,558 Publications

volumes

Volume 16 - 2025

A warming-yang herbal decoction protects against high-altitude hypoxia–induced osteoblast injury through modulation of HIF-1 signaling

Synergistic antitumor effects of astragalus polysaccharide: a preclinical systematic review and meta-analysis

Inflammatory response in CF airway epithelial cells: a comparative study of modulators and wild-type CFTR rescue

Identification of novel therapeutic targets and effective anticancer agents for gallbladder cancer by integrating bioinformatics analysis and experimental validation

Therapeutic trough mycophenolic acid levels positively correlate with omega-3 fatty acids in leukocytes of children with idiopathic nephrotic syndrome. a pilot study

Nonclinical evaluation of HS630, a proposed biosimilar of trastuzumab emtansine: affinity, pharmacokinetics, and immunogenicity

Mitophagy-related gene TRIP13 predicts prognosis and immune response and promotes proliferation and migration in vitro and in vivo of clear cell renal cell carcinoma

Voriconazole injection use in patients receiving continuous renal replacement therapy

Pharmacokinetics and safety of the antitumor drug everolimus in healthy Chinese subjects: a single-dose, open-label, randomized, two-sequence, two-period crossover, phase I bioequivalence study

Differential effects of PCSK9 inhibitors and statins on plasma ceramides in coronary artery disease

Intranasal delivery of iron chelators and management of central nervous system disease

Molecular mechanisms and multi-target therapeutic strategies of diabetic nephropathy: from pathogenesis to precision interventions

Harnessing natural terpenes via PEGylated mucoadhesive vesicles for improved urinary bladder delivery: from in vitro evaluation to in vivo assessment

Anti-inflammatory effect of a pimarane diterpenoid isolated from Nepeta adenophyta Hedge based on a network analysis approach and experimental assessment

Benefit-risk Assessment of the use of toxic botanical drugs in superiority field: A case study on Aconitum carmichaeli Debx

Efficacy and safety of efruxifermin for patients with NASH/MASH:an updated systematic review and meta-analysis

The mechanistic role of gitogenin as a treatment for laryngeal cancer: a network pharmacology and experimental analysis

Study on mechanism of action of β-elemene in inhibiting cisplatin resistance in lung cancer through LncRNA LINC00511

Rapid health technology assessment of six non-ergot dopamine-receptor agonists for the treatment of early Parkinson’s disease

Novel protein acylations in ferroptosis: decoding the regulatory roles of lactylation, crotonylation, succinylation, and β-hydroxybutyrylation

Research progress on the regulatory effects and mechanisms of natural active products on intestinal barrier function

Harnessing Curcumin in Oral Medicine: Mechanisms, Therapeutic Potential, and Future Innovations

Fedratinib reveals chemotherapeutic potential in esophageal squamous cell cancer

O-GlcNAcylation of eNOS in high-salt-induced thoracic aorta endothelial dysfunction in mice