Frontiers in Pharmacology

Original Research

Published on 16 Dec 2025

Integrated gut microbiota and metabolomics analysis reveals the antitumor effects of ergosta-4,6,8(14),22-tetraen-3-one purified from the medicinal fungus pholiota adiposa in tumor-bearing mice

Boyuan Liu
Junsen Qin
Shan Zheng
Jiaxin Zhang
Xuemei Hu
Xiaoyan Wang
Yan Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1653035

1,286 views

Review

Published on 16 Dec 2025

Recent advances in mineralocorticoid receptor antagonists for heart failure with preserved ejection fraction: focus on finerenone in the era of sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists

Tian-Yu Wang
Lei Zhang
Huan-Yi Wang
Fen-Fen Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1725782

2,598 views

Original Research

Published on 16 Dec 2025

Developing a value assessment index system of anti-tumour commercial Chinese polyherbal preparation in China: a modified Delphi study

Tongchao Xia
Min Hu
Chunmei Luo
Mengmeng Yang
Mingming Chu
Xing Xiang
Zhe Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681174

1,215 views

Original Research

Published on 16 Dec 2025

Total alkaloids of Corydalis saxicola Bunting ameliorate ulcerative colitis through regulation of metabolite networks and gut microbiota

Shuyi Jin
Xinyi Cheng
Feng Han
Qien Li
Jing Shang
Guoyong Xie
Minjian Qin

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721116

1,138 views

Correction

Published on 15 Dec 2025

Correction: Mitochondrial iron overload-mediated inhibition of Nrf2-HO-1/GPX4 assisted ALI-induced nephrotoxicity

Hui-Fang Deng
Lan-Xin Yue
Ning-Ning Wang
Yong-Qiang Zhou
Wei Zhou
Xian Liu
Yu-Hao Ni
Cong-Shu Huang
Li-Zhen Qiu
Hong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1734058

660 views

Editorial

Published on 15 Dec 2025

Editorial: Traditional, complementary and integrative medicine – opportunities for managing and treating neurodegenerative diseases and ischaemic stroke

Huazheng Liang
Chunguang Li
Bin Yu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1749624

874 views

Original Research

Published on 15 Dec 2025

Selective anti-cancer effects of cannabidiol and Δ9-tetrahydrocannabinol via PI3K/AKT/mTOR inhibition and PTEN restoration in ovarian cancer cells

Siyao Tong
Watcharin Loilome
Nisana Namwat
Poramate Klanrit
Arporn Wangwiwatsin
Zar Zar Win
Preeya Koyabuth
Bandit Chumworathayi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693129

6,474 views

Original Research

Published on 12 Dec 2025

Targeting lipogenesis promotes the synergistic effect of the selective HDAC6 inhibitor ITF3756 with bortezomib in colon cancer cells

Marzia Franzò
Chiara Zichittella
Diana Di Liberto
Giovanni Pratelli
Federica Affranchi
Antonietta Notaro
Michela Giuliano
Sonia Emanuele

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706770

1,442 views

Review

Published on 12 Dec 2025

Relevant pharmacokinetics, bioavailability, and bioequivalence studies on Chlorpheniramine maleate (various species): a review

César Alas-Pineda
Dennis J. Pavón-Varela
Kristhel Gaitán-Zambrano
Gustavo Ferrer

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1737690

2,267 views

Methods

Published on 12 Dec 2025

Development of an LC-MS/MS method to quantitatively analyze escitalopram and its metabolites with application in liver and placenta microsome metabolism

Yifei Shen
Bingyi Yao
Yuanqing Guo
Yujia Yang
Chenmeizi Liang
Junze Huang
Yuanjin Zhang
Xin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714686

1,147 views

Review

Published on 12 Dec 2025

Clinical relevance of PLK1 in epithelial ovarian cancer

Xiaochang Shen
Jiandong Wang
Shuning Chen
Haomeng Zhang
Chunxiao Zhou
Victoria L. Bae-Jump

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702273

1,167 views

Editorial

Published on 12 Dec 2025

Editorial: Cell death in kidney diseases: novel biomarkers, mechanisms, and therapeutic strategies

Min Chen
Yu Ning Liu
Wei Jing Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1715728

770 views

Original Research

Published on 12 Dec 2025

Medication adherence in the elderly population with chronic diseases: a factor analysis

Doris Cardona
Valeria Santacruz-Restrepo
Alejandra Rendón-Montoya
Juliana Madrigal-Cadavid
Alejandra Segura-Cardona
Jorge Iván Estrada-Acevedo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1699999

1,609 views

Original Research

Published on 12 Dec 2025

Alginate-encapsulated muscle-derived stem cell spheroids promote muscle regeneration in a murine model of volumetric muscle loss

Lucas Pari Mitre
Giovana Zanetti Ivanov
Shahin Shams
Fabio Yamaguchi
André Petraconi
Ricardo Jorge Espanhol Andrade
Eduardo Silva
Leonardo Martin
Roberta Sessa Stilhano

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657563

1,326 views

Original Research

Published on 12 Dec 2025

Coreopsis tinctoria Nutt. attenuates ultraviolet A photodamage by suppressing endoplasmic reticulum stress-induced apoptosis via Nrf2 crosstalk

Ling Liang
Xin Nie
Nan Zhao
Menggeng Li
Mingjie Li
Zhiwei Li
Man Wu
Xuanmin Wu
Cheuk-Lun Lee
Peng Shu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686234

996 views

Original Research

Published on 12 Dec 2025

Real-world disproportionality analysis of sleep disturbances associated with antiseizure medications in epilepsy: a pharmacovigilance study

Chen Gou
Mengshi Yang
Qingqing Zhao
Yanbing Han

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1740747

2,155 views

Original Research

Published on 12 Dec 2025

Exploring HSP90α and hs-CRP using AI models to predict prognosis in advanced hepatocellular carcinoma treated with PD-1 inhibitors and targeted therapy

Zhen-Ying Wu
Xueting Li
Lu Yang
Yuhui Shi
Xianguo Liu
Lianbin Wen
Yanqiong Song
Wanyun Du
Yulin Tu
Qian Wei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1726967

1,162 views

Original Research

Published on 11 Dec 2025

Practical utility of meropenem therapeutic drug monitoring: a systematic review of evidence for clinical application

Yi-Chang Zhao
Jia-Yi Liu
Jia-Kai Li
Huai-Yuan Liu
Zhi-Hua Sun
Bi-Kui Zhang
Miao Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1725419

1,769 views

Original Research

Published on 11 Dec 2025

Impact of the diverse cardiotonic steroids on beta-amyloid precursor protein level

Irina Yu. Petrushanko
Denis R. Lisitskii
Maria A. Strelkova
Anna P. Tolstova
Artemy P. Fedulov
Filipp A. Filonov
Vladimir A. Mitkevich
Alexander A. Makarov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1723629

1,251 views

Correction

Published on 11 Dec 2025

Correction: Anticancer effects of OSW-1 on glioma cells via regulation of the PI3K/AKT signal pathway: a network pharmacology approach and experimental validation in vitro and in vivo

Zhixin Zhan
Ziqiang Liu
Chaochao Zhang
Haijun Gao
Jiacheng Lai
Yong Chen
Haiyan Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1754450

652 views

Correction

Published on 11 Dec 2025

Correction: Terminal complement inhibition in atypical haemolytic uremic syndrome: a single-centre experience

Valentin D. Mocanu
Bogdan M. Sorohan
Elena G. Micu
Sonia Bălănică
Bogdan Obrişcă
Roxana A. Jurubiță
Camelia A. Achim
Adrian C. Lungu
Cristina S. Căpuşă
Gabriel Mircescu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1760223

688 views

Original Research

Published on 11 Dec 2025

Targeting a distinct binding pocket in the pregnane X receptor with natural agonist TRLW-2 ameliorates murine ulcerative colitis

Shangrui Rao
Yi Mei
Lingyan Shi
Hongzheng Li
Minyu Zhou
Ziyu Meng
Zhijie Zhao
Shaotang Li
Weijian Sun
Qiang Tian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1726597

1,454 views

Original Research

Published on 11 Dec 2025

Xin-Fu-Kang oral liquid improves cardiac function and attenuates miR-223–associated NF-κB/NLRP3 pyroptotic signaling in chronic heart failure

Zelin Ye
Mingrui Liu
Xiaohan Zhang
Huaqin Wu
Zhiling Qiu
Ruoning Chai
Yuanhui Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697422

1,409 views
1 citation

Original Research

Published on 11 Dec 2025

Ensemble learning approach with explainable AI for improved heart disease prediction

Ayomide Adekoya
Faisal Saeed
Wad Ghaban
Sultan Noman Qasem

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654681

1,074 views

29,558 Publications

volumes

Volume 16 - 2025

Integrated gut microbiota and metabolomics analysis reveals the antitumor effects of ergosta-4,6,8(14),22-tetraen-3-one purified from the medicinal fungus pholiota adiposa in tumor-bearing mice

Recent advances in mineralocorticoid receptor antagonists for heart failure with preserved ejection fraction: focus on finerenone in the era of sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists

Developing a value assessment index system of anti-tumour commercial Chinese polyherbal preparation in China: a modified Delphi study

Total alkaloids of Corydalis saxicola Bunting ameliorate ulcerative colitis through regulation of metabolite networks and gut microbiota

Correction: Mitochondrial iron overload-mediated inhibition of Nrf2-HO-1/GPX4 assisted ALI-induced nephrotoxicity

Editorial: Traditional, complementary and integrative medicine – opportunities for managing and treating neurodegenerative diseases and ischaemic stroke

Selective anti-cancer effects of cannabidiol and Δ9-tetrahydrocannabinol via PI3K/AKT/mTOR inhibition and PTEN restoration in ovarian cancer cells

Targeting lipogenesis promotes the synergistic effect of the selective HDAC6 inhibitor ITF3756 with bortezomib in colon cancer cells

Relevant pharmacokinetics, bioavailability, and bioequivalence studies on Chlorpheniramine maleate (various species): a review

Development of an LC-MS/MS method to quantitatively analyze escitalopram and its metabolites with application in liver and placenta microsome metabolism

Clinical relevance of PLK1 in epithelial ovarian cancer

Editorial: Cell death in kidney diseases: novel biomarkers, mechanisms, and therapeutic strategies

Medication adherence in the elderly population with chronic diseases: a factor analysis

Alginate-encapsulated muscle-derived stem cell spheroids promote muscle regeneration in a murine model of volumetric muscle loss

Coreopsis tinctoria Nutt. attenuates ultraviolet A photodamage by suppressing endoplasmic reticulum stress-induced apoptosis via Nrf2 crosstalk

Real-world disproportionality analysis of sleep disturbances associated with antiseizure medications in epilepsy: a pharmacovigilance study

Exploring HSP90α and hs-CRP using AI models to predict prognosis in advanced hepatocellular carcinoma treated with PD-1 inhibitors and targeted therapy

Practical utility of meropenem therapeutic drug monitoring: a systematic review of evidence for clinical application

Impact of the diverse cardiotonic steroids on beta-amyloid precursor protein level

Correction: Anticancer effects of OSW-1 on glioma cells via regulation of the PI3K/AKT signal pathway: a network pharmacology approach and experimental validation in vitro and in vivo

Correction: Terminal complement inhibition in atypical haemolytic uremic syndrome: a single-centre experience

Targeting a distinct binding pocket in the pregnane X receptor with natural agonist TRLW-2 ameliorates murine ulcerative colitis

Xin-Fu-Kang oral liquid improves cardiac function and attenuates miR-223–associated NF-κB/NLRP3 pyroptotic signaling in chronic heart failure

Ensemble learning approach with explainable AI for improved heart disease prediction