Frontiers in Pharmacology

Clinical Trial

Published on 19 Dec 2025

Effects and safety of a CBD-rich Cannabis sativa oil in knee osteoarthritis: a double-blind, randomized, placebo-controlled trial – CANOA – cannabis for osteoarthritis

Andrés Mojoli
Osvaldo Haider
Yasmin Fakih
Maria Victoria Luz Gonçalves
Bruno Zepeda Rojas
Giovanna Xaia
Emanuelly Krefta
Maíra Assunção Bicca
Thiago Lopes de Mari
Charles Francisco Ferreira

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657065

792 views

Systematic Review

Published on 19 Dec 2025

Effectiveness and safety of Ayurvedic intervention in essential hypertension: a systematic review with meta-analysis

Saylee Deshmukh
Kuldeep Choudhary
Azeem Ahmad
Govind Reddy
B. C. S. Rao
Narayanam Srikanth
Rabinarayan Acharya

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1695614

1,626 views

Original Research

Published on 19 Dec 2025

Systemic angiogenic protein changes following propranolol therapy in infantile hemangioma: a multi-target perspective

Lijun Liang
Yan Zhang
Yan Ma
Jing Liu
Wangnan Du
Qiang Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706048

588 views

Original Research

Published on 19 Dec 2025

Oleanolic acid cubic liquid crystal nanoparticle-based thermosensitive gel attenuates knee osteoarthritis symptoms in rats

Zhiqi Shi
Fan Jia
Xiaoyu Tang
Qing Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1730566

534 views

Original Research

Published on 19 Dec 2025

Generation of Phd2-haplodeficient macrophages with proresolution effects for the treatment of limb ischemia

Patrícia Terra Alves
Sayone Andrade de Moura
Helen Taylor
Antonella Fidanza
Cristiane Damas Gil
Leonardo Martin
Aléx Martins Nasare
André van Helvoort Lengert
Bianca Bonetto Moreno Garcia
Gabriel Cicolin Guarache

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1698623

644 views

Original Research

Published on 19 Dec 2025

Emodin and physcion alleviate cholestatic liver injury by targeting FXR: hepatoprotective components identified in processed Polygonum multiflorum Thunb. using a comprehensive two-dimensional biochromatography system

Zhihui Li
Yanqiu Gu
Jianbo Yang
Shaozhan Wang
Shengnan Li
Panpan Chen
Ru Yao
Fangbin Liu
Ying Wang
Rong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706401

658 views

Mini Review

Published on 19 Dec 2025

Abhraka Bhasma (mica based nanomedicine): an ayurvedic herbomineral perspective in breast cancer management

Dhanya Soman Pillai
Amarnath Karavettekudy Ranjit

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1656846

717 views

Case Report

Published on 19 Dec 2025

Case Report: Tislelizumab–induced panuveitis: a report of two cases

Huan Ding
Shuyuan Zhang
Lin Lin
Kaiyan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678663

734 views

Mini Review

Published on 19 Dec 2025

Transcriptional rewiring in cancer driven by POLR2A/RPB1: mechanistic insights, non-coding RNA crosstalk, and therapeutic opportunities

Adrian Szczepaniak
Kinga Jaskuła
Marta Zielińska
Jakub Godlewski

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1745087

646 views

Systematic Review

Published on 19 Dec 2025

Efficacy and safety of later-line targeted therapies in advanced non-small cell lung cancer with EGFR exon 20 insertion mutations: a systematic review

Qiang Wen
Yue Zhuang
Silv Fu
Chunguo Pan
Zhihua Liu
Lei Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1707050

1,256 views

Systematic Review

Published on 19 Dec 2025

Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis

Marta Mazur
Artnora Ndokaj
Claudia Salerno
Jessica Vallone
Roman Ardan
Sabina Bietolini
Florence Carrouel
Aleksandra Wilk
Rachel Sarig
Livia Ottolenghi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1602976

2,289 views

Original Research

Accepted on 18 Dec 2025

Integrative Multi-Omics and Experimental Analyses Implicate PTK2 as a Lorazepam-Associated Biomarker and Potential Therapeutic Target in Ovarian Cancer

Xia Hong
Xingjun He
Suli He

Frontiers in Pharmacology

257 views

Original Research

Accepted on 18 Dec 2025

Piperine Encapsulated in Solid Lipid Nanoparticles: A Promising Nano-Phytomedicine Approach for Non-Alcoholic Fatty Liver Disease Treatment

Afrasim Moin
Shwetha Ram
Sateesha SB
Talib Hussain
Amr Selim Abu Lila
Rajamma AJ
Syed Mohd Danish Rizvi
Sirajudheen Anwar
Chandan K

Frontiers in Pharmacology

266 views

Original Research

Accepted on 18 Dec 2025

Elevated somatostatin interneuron long-term potentiation minimally regulates temporoammonic LTP in a mouse model of Fragile X Syndrome

Max A Wilson
Anna Sumera
Emre Berk
Sam A Booker

Frontiers in Pharmacology

112 views

Original Research

Accepted on 18 Dec 2025

Pharmacological Activation of SIRT1-AMPK by Ginsenoside Rb1: A Novel Therapeutic Strategy for Pressure Injury via Dual Suppression of Ferroptosis and Inflammation

Hongbo Zhu
Hang Li
Yinong Shi
Hua Zhi
Xuelu Zhao
Zhiwen Wang
Jinhui Liu

Frontiers in Pharmacology

167 views

Review

Accepted on 18 Dec 2025

Plant Polysaccharides in Neuroprotection: Mechanistic Insights Across Central Nervous System Disorders.

Qiyue Yu
Hui Chen
Zhuofeng Qu
Jialin Qu
Yan Wang
Lina Liang
Shouyu Hu

Frontiers in Pharmacology

Original Research

Accepted on 18 Dec 2025

PTX-Loaded, Polysorbate 80-Functionalized Brain-Targeting Pullulan Nanoparticles for Drug Delivery

Huabing Yuan
Lu Han
Hao Deng
Yue Tan
Yi Yang
Yi Liu
Jiaxin Ying
Mengqi Fang
Hui Wei
Zhihe Tao

Frontiers in Pharmacology

163 views

Review

Accepted on 18 Dec 2025

The Role of Probiotics in Modulation of the Gut-Brain Axis: A Prospective Therapy for Depression and Mood Disorders

Hui Wang
Yining Chen
Allen Zhao
Zhongxia Shen
Yu Zhang

Frontiers in Pharmacology

219 views

Original Research

Accepted on 18 Dec 2025

Hypericin Alleviates Cerebral Ischemia/Reperfusion Injury by Modulating Endoplasmic Reticulum Stress

Tingting Li
Chao Wang

Frontiers in Pharmacology

122 views

Original Research

Accepted on 18 Dec 2025

Anwuligan promote the Transition of Hair Follicle Cycle via Wnt/β-catenin signaling pathway

Fang Li
Leyao Zhang
Yan Li
Xiang Zheng

Frontiers in Pharmacology

114 views

Editorial

Published on 18 Dec 2025

Editorial: Non-coding RNAs as potential therapeutics and biomarkers for human diseases

Margarida Gama-Carvalho
Alice Conigliaro
Chiara De Santi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1753536

538 views

Original Research

Published on 18 Dec 2025

Exploring medication adherence in racial/ethnic minorities

Joronia Chery
Lisa Gualtieri
Ian Lee
Grace Sheng
Meera Singhal
Sebastian Z. Ramos

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1670633

442 views

Original Research

Published on 18 Dec 2025

Bromhexine hydrochloride enhances the therapeutic efficacy of tiamulin against experimental Staphylococcus aureus infection in dogs: targeting bacterial virulence, boosting antioxidant defense, and improving histopathology

Hanem F. El-Gendy
Shimaa R. Masoud
Nagwa I. Sheraiba
Shimaa S. Elnahriry
Doaa A. Madkour
Reda M. S. Korany
Hazim O. Khalifa
Hanaa Y. Elnagar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1679854

575 views

Original Research

Published on 18 Dec 2025

Multimode MALDI-MSI deciphers matrine-induced metabolic reprogramming in prostate cancer xenografts: spatial mapping of low-molecular-weight compound alterations

Jia Xu
Liang Qin
Xiao Liang
Lulu Chen
Juexin Wang
Hua Guo
Fengmei Wang
Ran Wu
Xiaojing An
Wenjuan Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1627864

389 views

4,182 Publications

volumes

Effects and safety of a CBD-rich Cannabis sativa oil in knee osteoarthritis: a double-blind, randomized, placebo-controlled trial – CANOA – cannabis for osteoarthritis

Effectiveness and safety of Ayurvedic intervention in essential hypertension: a systematic review with meta-analysis

Systemic angiogenic protein changes following propranolol therapy in infantile hemangioma: a multi-target perspective

Oleanolic acid cubic liquid crystal nanoparticle-based thermosensitive gel attenuates knee osteoarthritis symptoms in rats

Generation of Phd2-haplodeficient macrophages with proresolution effects for the treatment of limb ischemia

Emodin and physcion alleviate cholestatic liver injury by targeting FXR: hepatoprotective components identified in processed Polygonum multiflorum Thunb. using a comprehensive two-dimensional biochromatography system

Abhraka Bhasma (mica based nanomedicine): an ayurvedic herbomineral perspective in breast cancer management

Case Report: Tislelizumab–induced panuveitis: a report of two cases

Transcriptional rewiring in cancer driven by POLR2A/RPB1: mechanistic insights, non-coding RNA crosstalk, and therapeutic opportunities

Efficacy and safety of later-line targeted therapies in advanced non-small cell lung cancer with EGFR exon 20 insertion mutations: a systematic review

Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis

Integrative Multi-Omics and Experimental Analyses Implicate PTK2 as a Lorazepam-Associated Biomarker and Potential Therapeutic Target in Ovarian Cancer

Piperine Encapsulated in Solid Lipid Nanoparticles: A Promising Nano-Phytomedicine Approach for Non-Alcoholic Fatty Liver Disease Treatment

Elevated somatostatin interneuron long-term potentiation minimally regulates temporoammonic LTP in a mouse model of Fragile X Syndrome

Pharmacological Activation of SIRT1-AMPK by Ginsenoside Rb1: A Novel Therapeutic Strategy for Pressure Injury via Dual Suppression of Ferroptosis and Inflammation

Plant Polysaccharides in Neuroprotection: Mechanistic Insights Across Central Nervous System Disorders.

PTX-Loaded, Polysorbate 80-Functionalized Brain-Targeting Pullulan Nanoparticles for Drug Delivery

The Role of Probiotics in Modulation of the Gut-Brain Axis: A Prospective Therapy for Depression and Mood Disorders

Hypericin Alleviates Cerebral Ischemia/Reperfusion Injury by Modulating Endoplasmic Reticulum Stress

Anwuligan promote the Transition of Hair Follicle Cycle via Wnt/β-catenin signaling pathway

Editorial: Non-coding RNAs as potential therapeutics and biomarkers for human diseases

Exploring medication adherence in racial/ethnic minorities

Bromhexine hydrochloride enhances the therapeutic efficacy of tiamulin against experimental Staphylococcus aureus infection in dogs: targeting bacterial virulence, boosting antioxidant defense, and improving histopathology

Multimode MALDI-MSI deciphers matrine-induced metabolic reprogramming in prostate cancer xenografts: spatial mapping of low-molecular-weight compound alterations