Frontiers in Pharmacology

Original Research

Published on 20 Jan 2022

Cycloastragenol Attenuates Osteoclastogenesis and Bone Loss by Targeting RANKL-Induced Nrf2/Keap1/ARE, NF-κB, Calcium, and NFATc1 Pathways

Gang Wang
Chao Ma
Kai Chen
Ziyi Wang
Heng Qiu
Delong Chen
Jianbo He
Cheng Zhang
Ding Guo
Boyong Lai

Frontiers in Pharmacology

doi 10.3389/fphar.2021.810322

5,703 views
31 citations

Original Research

Published on 19 Jan 2022

FGFC1 Selectively Inhibits Erlotinib-Resistant Non-Small Cell Lung Cancer via Elevation of ROS Mediated by the EGFR/PI3K/Akt/mTOR Pathway

Shike Yan
Bing Zhang
Jingwen Feng
Haigang Wu
Namin Duan
Yamin Zhu
Yueliang Zhao
Shuang Shen
Kai Zhang
Wenhui Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.764699

6,191 views
20 citations

Review

Published on 19 Jan 2022

The Effects of Crocin on Bone and Cartilage Diseases

Shayan Vafaei
Xuming Wu
Jiajie Tu
Seyed Noureddin Nematollahi-mahani

Frontiers in Pharmacology

doi 10.3389/fphar.2021.830331

9,251 views
18 citations

Review

Published on 19 Jan 2022

Trends in Antidiabetic Drug Discovery: FDA Approved Drugs, New Drugs in Clinical Trials and Global Sales

Amelia D. Dahlén
Giovanna Dashi
Ivan Maslov
Misty M. Attwood
Jörgen Jonsson
Vladimir Trukhan
Helgi B. Schiöth

Frontiers in Pharmacology

doi 10.3389/fphar.2021.807548

85,269 views
238 citations

Original Research

Published on 19 Jan 2022

Fenofibrate Improves Insulin Resistance and Hepatic Steatosis and Regulates the Let-7/SERCA2b Axis in High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease Mice

Dan Zhang
Shanzhuang Niu
Yicheng Ma
Hang Chen
Yu Wen
Mingke Li
Bo Zhou
Yi Deng
Chunjing Shi
Guangyu Pu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.770652

12,288 views
9 citations

Original Research

Published on 19 Jan 2022

The Gene Expression Analysis of Peripheral Blood Monocytes From Psoriasis Vulgaris Patients With Different Traditional Chinese Medicine Syndromes

Yue Lu
Yao Qi
Li Li
Yuhong Yan
Jianan Wei
Danni Yao
Jingjing Wu
Hao Deng
Jingwen Deng
Shuyan Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2021.759741

4,148 views
5 citations

Original Research

Published on 19 Jan 2022

A Frog Peptide Ameliorates Skin Photoaging Through Scavenging Reactive Oxygen Species

Guizhu Feng
Lin Wei
Helong Che
Yan Shen
Jun Yang
Kai Mi
Jin Liu
Jing Wu
Hailong Yang
Lixian Mu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.761011

9,666 views
23 citations

Mini Review

Published on 19 Jan 2022

Components of the Endocannabinoid System and Effects of Cannabinoids Against Bone Diseases: A Mini-Review

Yuqi Xin
Anqun Tang
Shuting Pan
Jie Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.793750

9,997 views
14 citations

Review

Published on 19 Jan 2022

Biologics in Asthma: A Molecular Perspective to Precision Medicine

Brittany Salter
Paige Lacy
Manali Mukherjee

Frontiers in Pharmacology

doi 10.3389/fphar.2021.793409

16,620 views
61 citations

Original Research

Published on 19 Jan 2022

Echinocystic Acid Inhibits Inflammation and Exerts Neuroprotective Effects in MPTP-Induced Parkinson’s Disease Model Mice

Dewei He
Guiqiu Hu
Ang Zhou
Yanting Liu
Bingxu Huang
Yingchun Su
Hefei Wang
Bojian Ye
Yuan He
Xiyu Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2021.787771

5,033 views
19 citations

Original Research

Published on 19 Jan 2022

Insulin Treatment of Hypertriglyceridemia During Pregnancy

De-cui Cheng
Yao Su
Feifei Li
Xianming Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.785756

4,130 views
7 citations

Original Research

Published on 19 Jan 2022

DDIT: An Online Predictor for Multiple Clinical Phenotypic Drug-Disease Associations

Lu Lu
Jiale Qin
Jiandong Chen
Hao Wu
Qiang Zhao
Satoru Miyano
Yaozhong Zhang
Hua Yu
Chen Li

Frontiers in Pharmacology

doi 10.3389/fphar.2021.772026

6,220 views
2 citations

Original Research

Published on 19 Jan 2022

Physiologically Based Pharmacokinetic Modeling in Pregnant Women Suggests Minor Decrease in Maternal Exposure to Olanzapine

Liang Zheng
Hongyi Yang
André Dallmann
Xuehua Jiang
Ling Wang
Wei Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.793346

6,496 views
22 citations

Original Research

Published on 19 Jan 2022

Systems Pharmacology Modeling Identifies a Novel Treatment Strategy for Bortezomib-Induced Neuropathic Pain

Peter Bloomingdale
Cristina Meregalli
Kevin Pollard
Annalisa Canta
Alessia Chiorazzi
Giulia Fumagalli
Laura Monza
Eleonora Pozzi
Paola Alberti
Elisa Ballarini

Frontiers in Pharmacology

doi 10.3389/fphar.2021.817236

6,563 views
14 citations

Review

Published on 19 Jan 2022

Idiopathic Pulmonary Fibrosis: An Update on Pathogenesis

Qianru Mei
Zhe Liu
He Zuo
Zhenhua Yang
Jing Qu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.797292

61,769 views
302 citations

Original Research

Published on 19 Jan 2022

Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro

Senem Merve Fred
Suvi Kuivanen
Hasan Ugurlu
Plinio Cabrera Casarotto
Lev Levanov
Kalle Saksela
Olli Vapalahti
Eero Castrén

Frontiers in Pharmacology

doi 10.3389/fphar.2021.755600

9,911 views
57 citations

Editorial

Published on 19 Jan 2022

Editorial: Pharmacological Treatments Affecting Gastro-Intestinal Motility in Man

E. Scarpellini
G. Ianiro
J. Tack

Frontiers in Pharmacology

doi 10.3389/fphar.2021.801136

2,745 views
2 citations

Review

Published on 19 Jan 2022

Salvia miltiorrhiza Bge. (Danshen) for Inflammatory Bowel Disease: Clinical Evidence and Network Pharmacology-Based Strategy for Developing Supplementary Medical Application

Siyuan Zhang
Hua Luo
Shiyi Sun
Yating Zhang
Jiaqi Ma
Yuting Lin
Lin Yang
Dechao Tan
Chaomei Fu
Zhangfeng Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2021.741871

9,074 views
22 citations

Review

Published on 19 Jan 2022

Immunotherapy and Gene Therapy: New Challenges in the Diagnosis and Management of Drug-Induced Liver Injury

Bénédicte Delire
Eleonora De Martin
Lucy Meunier
Dominique Larrey
Yves Horsmans

Frontiers in Pharmacology

doi 10.3389/fphar.2021.786174

8,938 views
20 citations

Review

Published on 19 Jan 2022

Understanding the Emerging Link Between Circadian Rhythm, Nrf2 Pathway, and Breast Cancer to Overcome Drug Resistance

Supriya Bevinakoppamath
Shobha Chikkavaddaragudi Ramachandra
Anshu Kumar Yadav
Vijaya Basavaraj
Prashant Vishwanath
Akila Prashant

Frontiers in Pharmacology

doi 10.3389/fphar.2021.719631

9,862 views
36 citations

Original Research

Published on 19 Jan 2022

Integrating Network Analysis and Metabolomics to Reveal Mechanism of Huaganjian Decoction in Treatment of Cholestatic Hepatic Injury

Qin Dong
Jiao Chen
Yan-Ping Jiang
Zong-Ping Zhu
Yong-Feng Zheng
Jin-Ming Zhang
Zhen Zhang
Wen-Qing Chen
Shi-Yi Sun
Lan Pang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.773957

4,399 views
3 citations

Original Research

Published on 19 Jan 2022

Multifactoriality of Parkinson’s Disease as Explored Through Human Neural Stem Cells and Their Transplantation in Middle-Aged Parkinsonian Mice

Anna Nelke
Silvia García-López
Alberto Martínez-Serrano
Marta P. Pereira

Frontiers in Pharmacology

doi 10.3389/fphar.2021.773925

4,600 views
5 citations

Original Research

Published on 19 Jan 2022

Deciphering the Effective Constituents and Mechanisms of Portulaca oleracea L. for Treating NASH via Integrating Bioinformatics Analysis and Experimental Pharmacology

Xiaoli He
Yiren Hu
Wei Liu
Guanghao Zhu
Ruoxi Zhang
Jiawen You
Yanting Shao
Yunhao Li
Zeng Zhang
Jingang Cui

Frontiers in Pharmacology

doi 10.3389/fphar.2021.818227

5,368 views
11 citations

Original Research

Published on 19 Jan 2022

Hermansky-Pudlak Syndrome: Identification of Novel Variants in the Genes HPS3, HPS5, and DTNBP1 (HPS-7)

Doris Boeckelmann
Mira Wolter
Katharina Neubauer
Felix Sobotta
Antonia Lenz
Hannah Glonnegger
Barbara Käsmann-Kellner
Jasmin Mann
Stephan Ehl
Barbara Zieger

Frontiers in Pharmacology

doi 10.3389/fphar.2021.786937

5,762 views
14 citations

4,137 Publications

volumes

Cycloastragenol Attenuates Osteoclastogenesis and Bone Loss by Targeting RANKL-Induced Nrf2/Keap1/ARE, NF-κB, Calcium, and NFATc1 Pathways

FGFC1 Selectively Inhibits Erlotinib-Resistant Non-Small Cell Lung Cancer via Elevation of ROS Mediated by the EGFR/PI3K/Akt/mTOR Pathway

The Effects of Crocin on Bone and Cartilage Diseases

Trends in Antidiabetic Drug Discovery: FDA Approved Drugs, New Drugs in Clinical Trials and Global Sales

Fenofibrate Improves Insulin Resistance and Hepatic Steatosis and Regulates the Let-7/SERCA2b Axis in High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease Mice

The Gene Expression Analysis of Peripheral Blood Monocytes From Psoriasis Vulgaris Patients With Different Traditional Chinese Medicine Syndromes

A Frog Peptide Ameliorates Skin Photoaging Through Scavenging Reactive Oxygen Species

Components of the Endocannabinoid System and Effects of Cannabinoids Against Bone Diseases: A Mini-Review

Biologics in Asthma: A Molecular Perspective to Precision Medicine

Echinocystic Acid Inhibits Inflammation and Exerts Neuroprotective Effects in MPTP-Induced Parkinson’s Disease Model Mice

Insulin Treatment of Hypertriglyceridemia During Pregnancy

DDIT: An Online Predictor for Multiple Clinical Phenotypic Drug-Disease Associations

Physiologically Based Pharmacokinetic Modeling in Pregnant Women Suggests Minor Decrease in Maternal Exposure to Olanzapine

Systems Pharmacology Modeling Identifies a Novel Treatment Strategy for Bortezomib-Induced Neuropathic Pain

Idiopathic Pulmonary Fibrosis: An Update on Pathogenesis

Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro

Editorial: Pharmacological Treatments Affecting Gastro-Intestinal Motility in Man

Salvia miltiorrhiza Bge. (Danshen) for Inflammatory Bowel Disease: Clinical Evidence and Network Pharmacology-Based Strategy for Developing Supplementary Medical Application

Immunotherapy and Gene Therapy: New Challenges in the Diagnosis and Management of Drug-Induced Liver Injury

Understanding the Emerging Link Between Circadian Rhythm, Nrf2 Pathway, and Breast Cancer to Overcome Drug Resistance

Integrating Network Analysis and Metabolomics to Reveal Mechanism of Huaganjian Decoction in Treatment of Cholestatic Hepatic Injury

Multifactoriality of Parkinson’s Disease as Explored Through Human Neural Stem Cells and Their Transplantation in Middle-Aged Parkinsonian Mice

Deciphering the Effective Constituents and Mechanisms of Portulaca oleracea L. for Treating NASH via Integrating Bioinformatics Analysis and Experimental Pharmacology

Hermansky-Pudlak Syndrome: Identification of Novel Variants in the Genes HPS3, HPS5, and DTNBP1 (HPS-7)