Frontiers in Psychiatry | Molecular Psychiatry

Original Research

Published on 02 Jan 2026

SENP3/FIS1-regulated PFC neural mitochondrial fragmentation underlies the mechanism of electroacupuncture attenuating depressive behavior in CUMS mice

in Molecular Psychiatry

Shaoda Lai
Xiaoke Qiu
Peilin Lin
Jiayi Wu
Feifei Li
Ningjing Lai
Xin Li
Ting Tu
Jiping Zhang
Yong Huang

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1645757

144 views

Original Research

Accepted on 29 Dec 2025

DNMT Gene Expression in Peripheral Leukocytes in Schizophrenia and Correlations with One-Carbon Metabolites: Folate, Total Homocysteine, and Vitamin B6

in Molecular Psychiatry

Yukiko Tomioka*
Masahito Nakataki
Hidehiro Umehara
Tomohiro Yoshida
Hiroya Matsuda
Yui Matsumoto
Mariko Aoki
Yuri Yoshida
Yuichiro Kamiyama
Tomohiko Nakayama

Frontiers in Psychiatry

Original Research

Accepted on 18 Dec 2025

Clinical Implications of Admission Anemia for Electroconvulsive Therapy Planning in Adolescent Major Depressive Disorder: Identifying Vulnerable Subgroups with Poorer Response

in Molecular Psychiatry

Dandan Geng
Heyan Xu
Jijia Gou
Yuna Wang
Yujia Chen
Su Hong
Li Kuang

Frontiers in Psychiatry

100 views

Original Research

Accepted on 11 Dec 2025

Comparing tryptophan, serotonin, kynurenine, quinolinic acid plasma levels, and their ratios between patients with bipolar disorder and healthy controls: do depressive episode or post-traumatic stress disorder (PTSD) symptoms matter?

in Molecular Psychiatry

Valerio Dell’Oste
Lionella Palego
Andrea Bordacchini
Berenice Rimoldi
Livia Parrini
Virginia Pedrinelli
Gino Giannaccini
Laura Betti
Claudia Carmassi

Frontiers in Psychiatry

132 views

Original Research

Published on 11 Dec 2025

Claudin-5 and inflammatory biomarkers in panic disorder: a 6-week follow-up study

in Molecular Psychiatry

Dilek Örüm
Zekiye Çatak
Ali Baran Tanrıkulu
Murad Atmaca

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1703509

468 views

Original Research

Published on 08 Dec 2025

Association between olanzapine and immune function in lung cancer patients with anxiety and depression: a retrospective cohort study of medical records

in Molecular Psychiatry

Shang Chen
Guizhong Huang
Sen Lei
Xiaojun Lin

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1655599

533 views

Original Research

Accepted on 01 Dec 2025

Lack of striatal-enriched protein tyrosine phosphatase STEP affected serotonin system, behavior, and brain morphology in mice

in Molecular Psychiatry

Vitalii Sergeevich Moskaliuk
Polina Dmitrievna Komleva
Nikita Valerievich Khotskin
Alla Borisovna Arefieva
Oleg Borisovich Shevelev
Alexey Nikolaevich Korablev
Nariman Rashitovich Battulin
Irina Alexandrovna Serova
Alexander Viktorovich Kulikov
Vladimir Sergeevich Naumenko

Frontiers in Psychiatry

178 views

Original Research

Accepted on 20 Nov 2025

Quantitative susceptibility mapping of deep brain nuclei in 22q11.2 deletion syndrome

in Molecular Psychiatry

Nestor Muñoz
Marisleydis García
Analía Cuiza
Angeles Tepper
Javiera Vásquez
Juan Pablo Ramirez-Mahaluf
Daniella Barbagelata
Juan Aguirre
María Elisa Maldonado
Claudia Ornstein

Frontiers in Psychiatry

232 views

Original Research

Published on 07 Nov 2025

Identification and experimental validation of common genes associated with both pulmonary arterial hypertension and major depressive disorder

in Molecular Psychiatry

Yan Yan
Mohammad Ismail Hajary Sagor
Liang Chen
Huakan Lin
Gufeng Gao
Guili Lian
Liangdi Xie

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1670519

901 views

Original Research

Published on 29 Oct 2025

Hyperresponsiveness to inflammatory stimulation in human neuronal-like cells from patients with inflammation-associated depression

in Molecular Psychiatry

Susanne Elisa Schillo
Carmen Schiweck
Mareike Aichholzer
Anna Y. Yotova
Tsendmaa Tsengenbayar
Sharmili Edwin Thanarajah
Andreas Reif
Florian Freudenberg

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1576880

940 views

Original Research

Published on 22 Oct 2025

Th17-related cytokines and chemokines are associated with immune dysregulation and severity in schizophrenia

in Molecular Psychiatry

Han Liang
Jing Xu

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1675129

1,253 views

Systematic Review

Published on 16 Oct 2025

Mapping current research on biomarkers associated with the diagnosis of pedophilia: a scoping review

in Molecular Psychiatry

Maria Karanikola
Anna T. El Riz
Andreas Chatzittofis

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1627198

4,254 views

Mini Review

Published on 15 Sep 2025

Isotope-specific lithium bioactivity – physiological reality or laboratory oddity?

in Molecular Psychiatry

Cecile Delacour
Marshall Deline
Hildigunnur Hermannsdóttir
Zhaoqi Lu
Michel J. P. Gingras
Tobias Fromme

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1664092

3,876 views

Original Research

Published on 10 Sep 2025

Preliminary exploration of potential biomarkers for heart failure and bipolar disorder: an exploratory study based on bioinformatics

in Molecular Psychiatry

Wei Zhang
Na Li

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1627105

2,221 views

Original Research

Published on 04 Sep 2025

Integrated bioinformatics and machine learning identify S100A9 and VGLL1 as hub genes for schizophrenia

in Molecular Psychiatry

Jiankang Lv
Xueru Wang
Wei Qin

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1621219

3,264 views

Review

Published on 02 Sep 2025

Neurobiological mechanisms of the effect of exercise on depressive disorder: analysis using CiteSpace

in Molecular Psychiatry

Haiying Yang
Jiayi Xu
Lei Hou
Dejian Huang

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1600286

3,513 views

Original Research

Published on 12 Aug 2025

Multi-omics investigation of metabolic dysregulation in depression: integrating metabolomics, weighted gene co-expression network analysis, and mendelian randomization

in Molecular Psychiatry

Wu Qianhao
Zhang Jinwen
Miao Jingjie
Chen Xiaoyu
Zhao Yangfei
Yao Wenxiu
Jiang Xu
Wang Xiaojun
Han Peipei
Guo Qi

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1627020

2,842 views

Mini Review

Published on 23 Jul 2025

Beyond vertebrates: Drosophila melanogaster as a model to study negative symptoms of schizophrenia

in Molecular Psychiatry

Maximiliano Elgueta-Reyes
Sergio Hidalgo
Jorge M. Campusano

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1622281

3,648 views

Opinion

Published on 22 Jul 2025

CB1 receptor and psychosis: friend, foe, or both

in Molecular Psychiatry

Jagadeesh S. Rao
Maria Alejandra Tangarife
Diego A. Rodríguez-Soacha
Ram Mukunda

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1630080

1,871 views

Original Research

Published on 14 Jul 2025

Deciphering transcriptomic signatures in schizophrenia, bipolar disorder, and major depressive disorder

in Molecular Psychiatry

Priyanka
Rajesh Kumar
Vinod Kumar
Ashwani Kumar
Sandeep Singh Rana

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1574458

4,114 views
1 citation

Original Research

Published on 01 Jul 2025

Lurasidone induces developmental toxicity and behavioral impairments in zebrafish embryos

in Molecular Psychiatry

Wentian Li
Fang Wang
Zhe Feng
Qianqian Cheng
Yuqing Huang
Lisheng Zhu
Han Xiao
Hongjian Gong

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1581524

2,371 views

Original Research

Published on 27 Jun 2025

Integrating weighted gene co-expression network analysis and machine learning to elucidate neural characteristics in a mouse model of depression

in Molecular Psychiatry

Jinli Gao
Qinglang Wang
Jie Liu
Siqian Zheng
Jiahong Liu
Zhiyong Gao
Cheng Zhu

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1564095

1,963 views
1 citation

Original Research

Published on 27 Jun 2025

Psychiatric safety associated with hormone replacement therapy for menopausal symptoms: a real-world study of the FDA adverse event reporting system

in Molecular Psychiatry

Nan Chen
Lei Li
Chun-li Fu
Yi Ren

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1614087

4,540 views

Editorial

Published on 04 Jun 2025

Editorial: Advances, opportunities and challenges of using modern AGI and AIGC technologies in depression and related disorders

in Molecular Psychiatry

Ming D. Li
Yunpeng Wang

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1625579

3,068 views
1 citation

524 articles

articles

SENP3/FIS1-regulated PFC neural mitochondrial fragmentation underlies the mechanism of electroacupuncture attenuating depressive behavior in CUMS mice

DNMT Gene Expression in Peripheral Leukocytes in Schizophrenia and Correlations with One-Carbon Metabolites: Folate, Total Homocysteine, and Vitamin B6

Clinical Implications of Admission Anemia for Electroconvulsive Therapy Planning in Adolescent Major Depressive Disorder: Identifying Vulnerable Subgroups with Poorer Response

Comparing tryptophan, serotonin, kynurenine, quinolinic acid plasma levels, and their ratios between patients with bipolar disorder and healthy controls: do depressive episode or post-traumatic stress disorder (PTSD) symptoms matter?

Claudin-5 and inflammatory biomarkers in panic disorder: a 6-week follow-up study

Association between olanzapine and immune function in lung cancer patients with anxiety and depression: a retrospective cohort study of medical records

Lack of striatal-enriched protein tyrosine phosphatase STEP affected serotonin system, behavior, and brain morphology in mice

Quantitative susceptibility mapping of deep brain nuclei in 22q11.2 deletion syndrome

Identification and experimental validation of common genes associated with both pulmonary arterial hypertension and major depressive disorder

Hyperresponsiveness to inflammatory stimulation in human neuronal-like cells from patients with inflammation-associated depression

Th17-related cytokines and chemokines are associated with immune dysregulation and severity in schizophrenia

Mapping current research on biomarkers associated with the diagnosis of pedophilia: a scoping review

Isotope-specific lithium bioactivity – physiological reality or laboratory oddity?

Preliminary exploration of potential biomarkers for heart failure and bipolar disorder: an exploratory study based on bioinformatics

Integrated bioinformatics and machine learning identify S100A9 and VGLL1 as hub genes for schizophrenia

Neurobiological mechanisms of the effect of exercise on depressive disorder: analysis using CiteSpace

Multi-omics investigation of metabolic dysregulation in depression: integrating metabolomics, weighted gene co-expression network analysis, and mendelian randomization

Beyond vertebrates: Drosophila melanogaster as a model to study negative symptoms of schizophrenia

CB1 receptor and psychosis: friend, foe, or both

Deciphering transcriptomic signatures in schizophrenia, bipolar disorder, and major depressive disorder

Lurasidone induces developmental toxicity and behavioral impairments in zebrafish embryos

Integrating weighted gene co-expression network analysis and machine learning to elucidate neural characteristics in a mouse model of depression

Psychiatric safety associated with hormone replacement therapy for menopausal symptoms: a real-world study of the FDA adverse event reporting system

Editorial: Advances, opportunities and challenges of using modern AGI and AIGC technologies in depression and related disorders