Frontiers in Toxicology | In Vitro Toxicology

Review

Published on 17 Jul 2024

Unleashing the potential of cell painting assays for compound activities and hazards prediction

in In Vitro Toxicology

Floriane Odje
David Meijer
Elena von Coburg
Justin J. J. van der Hooft
Sebastian Dunst
Marnix H. Medema
Andrea Volkamer

Frontiers in Toxicology

doi 10.3389/ftox.2024.1401036

8,586 views
7 citations

Original Research

Published on 13 Jun 2024

Optimisation of an in vitro human cardiovascular model on-a-chip for toxicological assessment of nicotine delivery products

in In Vitro Toxicology

Fiona Chapman
Luuk de Haan
Linda Gijzen
Wouter Strijker
Edgar Trelles Sticken
Sarah Jean Pour
Roman Wieczorek
Florian Haberstroh
Sandra Otte
Thomas Nahde

Frontiers in Toxicology

doi 10.3389/ftox.2024.1395670

6,186 views
2 citations

Review

Published on 13 Jun 2024

Applying new approach methodologies to assess next-generation tobacco and nicotine products

in In Vitro Toxicology

David Thorne
Damian McHugh
Liam Simms
K. Monica Lee
Hitoshi Fujimoto
Sara Moses
Marianna Gaca

Frontiers in Toxicology

doi 10.3389/ftox.2024.1376118

7,835 views
5 citations

Original Research

Published on 11 Apr 2024

Use of quantitative in vitro to in vivo extrapolation (QIVIVE) for the assessment of non-combustible next-generation product aerosols

in In Vitro Toxicology

Marjory Moreau
Liam Simms
Melvin E. Andersen
Edgar Trelles Sticken
Roman Wieczorek
Sarah Jean Pour
Fiona Chapman
Karin Roewer
Sandra Otte
Jeffrey Fisher

Frontiers in Toxicology

doi 10.3389/ftox.2024.1373325

5,287 views
14 citations

Correction

Published on 25 Mar 2024

Corrigendum: Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project

in In Vitro Toxicology

Albert Braeuning
Patrick Balaguer
William Bourguet
Jordi Carreras-Puigvert
Katreece Feiertag
Jorke H. Kamstra
Dries Knapen
Dajana Lichtenstein
Philip Marx-Stoelting
Jonne Rietdijk

Frontiers in Toxicology

doi 10.3389/ftox.2024.1394396

1,875 views

Original Research

Published on 12 Mar 2024

Evaluation of the applicability of GARDskin to predict skin sensitizers in extracts from medical device materials

in In Vitro Toxicology

Rose-Marie Jenvert
Olivia Larne
Angelica Johansson
Mattias Berglin
Emma Pedersen
Henrik Johansson

Frontiers in Toxicology

doi 10.3389/ftox.2024.1320367

4,152 views
3 citations

Original Research

Published on 28 Feb 2024

Use of in vitro methods combined with in silico analysis to identify potential skin sensitizers in the Tox21 10K compound library

in In Vitro Toxicology

Zhengxi Wei
Tuan Xu
Judy Strickland
Li Zhang
Yuhong Fang
Dingyin Tao
Anton Simeonov
Ruili Huang
Nicole C. Kleinstreuer
Menghang Xia

Frontiers in Toxicology

doi 10.3389/ftox.2024.1321857

4,660 views
5 citations

Editorial

Published on 01 Feb 2024

Editorial: Emerging talents in toxicology

in In Vitro Toxicology

Takamitsu A. Kato

Frontiers in Toxicology

doi 10.3389/ftox.2024.1369297

1,405 views

Original Research

Published on 23 Jan 2024

Liquid application dosing alters the physiology of air-liquid interface (ALI) primary human bronchial epithelial cell/lung fibroblast co-cultures and in vitro testing relevant endpoints

in In Vitro Toxicology

Nicholas M. Mallek
Elizabeth M. Martin
Lisa A. Dailey
Shaun D. McCullough

Frontiers in Toxicology

doi 10.3389/ftox.2023.1264331

8,299 views
16 citations

Mini Review

Published on 11 Oct 2023

Race, pigmentation, and the human skin barrier—considerations for dermal absorption studies

in In Vitro Toxicology

Alec T. Salminen
Prashiela Manga
Luísa Camacho

Frontiers in Toxicology

doi 10.3389/ftox.2023.1271833

7,311 views
11 citations

Brief Research Report

Published on 25 Jul 2023

Experimental exposure assessment for in vitro cell-based bioassays in 96- and 384-well plates

in In Vitro Toxicology

Julia Huchthausen
Maria König
Beate I. Escher
Luise Henneberger

Frontiers in Toxicology

doi 10.3389/ftox.2023.1221625

3,008 views
6 citations

Mini Review

Published on 19 Jul 2023

Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment

in In Vitro Toxicology

Thalia De Castelbajac
Kiara Aiello
Celia Garcia Arenas
Terje Svingen
Louise Ramhøj
Daniel Zalko
Robert Barouki
Tamara Vanhaecke
Vera Rogiers
Marc Audebert

Frontiers in Toxicology

doi 10.3389/ftox.2023.1216369

5,876 views
21 citations

Review

Published on 10 Jul 2023

New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens—a PARC project

in In Vitro Toxicology

Marc Audebert
Ann-Sophie Assmann
Amaya Azqueta
Pavel Babica
Emilio Benfenati
Sylvie Bortoli
Peter Bouwman
Albert Braeuning
Tanja Burgdorf
Xavier Coumoul

Frontiers in Toxicology

doi 10.3389/ftox.2023.1220998

9,619 views
23 citations

Perspective

Published on 29 Jun 2023

Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project

in In Vitro Toxicology

Albert Braeuning
Patrick Balaguer
William Bourguet
Jordi Carreras-Puigvert
Katreece Feiertag
Jorke H. Kamstra
Dries Knapen
Dajana Lichtenstein
Philip Marx-Stoelting
Jonne Rietdijk

Frontiers in Toxicology

doi 10.3389/ftox.2023.1212509

6,312 views
22 citations

Brief Research Report

Published on 04 May 2023

Development of a bioprinter-based method for incorporating metabolic competence into high-throughput in vitro assays

in In Vitro Toxicology

Kristen Hopperstad
Chad Deisenroth

Frontiers in Toxicology

doi 10.3389/ftox.2023.1196245

2,579 views
8 citations

Original Research

Published on 03 May 2023

Substantiate a read-across hypothesis by using transcriptome data—A case study on volatile diketones

in In Vitro Toxicology

Christina Drake
Matthias M. Wehr
Walter Zobl
Jeannette Koschmann
David De Lucca
Britta A. Kühne
Tanja Hansen
Jan Knebel
Detlef Ritter
Jan Boei

Frontiers in Toxicology

doi 10.3389/ftox.2023.1155645

3,704 views
4 citations

Review

Published on 24 Apr 2023

A review of complex in vitro cell culture stressing the importance of fluid flow and illustrated by organ on a chip liver models

in In Vitro Toxicology

John Malcolm Wilkinson

Frontiers in Toxicology

doi 10.3389/ftox.2023.1170193

7,476 views
19 citations

Original Research

Published on 04 Apr 2023

High-throughput AR dimerization assay identifies androgen disrupting chemicals and metabolites

in In Vitro Toxicology

Evan C. Brown
Daniel R. Hallinger
Steven O. Simmons

Frontiers in Toxicology

doi 10.3389/ftox.2023.1134783

3,948 views
3 citations

Original Research

Published on 08 Mar 2023

How to facilitate the implementation of 3D models in China by applying good in vitro method practice for regulatory use

in In Vitro Toxicology

Yanfeng Liu
Zhenzi Cai
Nan Li
Nathalie Alépée

Frontiers in Toxicology

doi 10.3389/ftox.2023.1080528

2,518 views
1 citation

Original Research

Published on 21 Feb 2023

Inhibition of matrix metalloproteinases by HIV-1 integrase strand transfer inhibitors

in In Vitro Toxicology

Emma G. Foster
Nicholas Y. Palermo
Yutong Liu
Benson Edagwa
Howard E. Gendelman
Aditya N. Bade

Frontiers in Toxicology

doi 10.3389/ftox.2023.1113032

3,679 views
6 citations

Original Research

Published on 16 Feb 2023

Twenty-eight day repeated exposure of human 3D bronchial epithelial model to heated tobacco aerosols indicates decreased toxicological responses compared to cigarette smoke

in In Vitro Toxicology

Fiona Chapman
Sarah Jean Pour
Roman Wieczorek
Edgar Trelles Sticken
Jessica Budde
Karin Röwer
Sandra Otte
Elizabeth Mason
Lukasz Czekala
Thomas Nahde

Frontiers in Toxicology

doi 10.3389/ftox.2023.1076752

7,836 views
9 citations

Original Research

Published on 14 Dec 2022

Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells

in In Vitro Toxicology

Francesca V. LoBianco
Kimberly J. Krager
Erica Johnson
Christopher O. Godwin
Antino R. Allen
Peter A. Crooks
Cesar M. Compadre
Michael J. Borrelli
Nukhet Aykin-Burns

Frontiers in Toxicology

doi 10.3389/ftox.2022.936149

5,094 views
17 citations

Editorial

Published on 10 Nov 2022

Editorial: Chemical testing using new approach methodologies (NAMs)

in In Vitro Toxicology

Andreas O. Stucki
Amy J. Clippinger
Tala R. Henry
Carole Hirn
Todd J. Stedeford
Claire Terry

Frontiers in Toxicology

doi 10.3389/ftox.2022.1048900

3,848 views
16 citations

Original Research

Published on 24 Oct 2022

Markers for DNA damage are induced in the rat colon by the Alternaria toxin altertoxin-II, but not a complex extract of cultured Alternaria alternata

in In Vitro Toxicology

Georg Aichinger
Gudrun Pahlke
Hannes Puntscher
Julia Groestlinger
Stephanie Grabher
Dominik Braun
Katharina Tillmann
Roberto Plasenzotti
Giorgia Del Favero
Benedikt Warth

Frontiers in Toxicology

doi 10.3389/ftox.2022.977147

3,689 views
6 citations

108 articles

articles

Unleashing the potential of cell painting assays for compound activities and hazards prediction

Optimisation of an in vitro human cardiovascular model on-a-chip for toxicological assessment of nicotine delivery products

Applying new approach methodologies to assess next-generation tobacco and nicotine products

Use of quantitative in vitro to in vivo extrapolation (QIVIVE) for the assessment of non-combustible next-generation product aerosols

Corrigendum: Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project

Evaluation of the applicability of GARDskin to predict skin sensitizers in extracts from medical device materials

Use of in vitro methods combined with in silico analysis to identify potential skin sensitizers in the Tox21 10K compound library

Editorial: Emerging talents in toxicology

Liquid application dosing alters the physiology of air-liquid interface (ALI) primary human bronchial epithelial cell/lung fibroblast co-cultures and in vitro testing relevant endpoints

Race, pigmentation, and the human skin barrier—considerations for dermal absorption studies

Experimental exposure assessment for in vitro cell-based bioassays in 96- and 384-well plates

Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment

New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens—a PARC project

Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project

Development of a bioprinter-based method for incorporating metabolic competence into high-throughput in vitro assays

Substantiate a read-across hypothesis by using transcriptome data—A case study on volatile diketones

A review of complex in vitro cell culture stressing the importance of fluid flow and illustrated by organ on a chip liver models

High-throughput AR dimerization assay identifies androgen disrupting chemicals and metabolites

How to facilitate the implementation of 3D models in China by applying good in vitro method practice for regulatory use

Inhibition of matrix metalloproteinases by HIV-1 integrase strand transfer inhibitors

Twenty-eight day repeated exposure of human 3D bronchial epithelial model to heated tobacco aerosols indicates decreased toxicological responses compared to cigarette smoke

Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells

Editorial: Chemical testing using new approach methodologies (NAMs)

Markers for DNA damage are induced in the rat colon by the Alternaria toxin altertoxin-II, but not a complex extract of cultured Alternaria alternata