Frontiers in Toxicology | In Vitro Toxicology

Original Research

Published on 23 Sep 2022

In vitro biotransformation assays using fish liver cells: Comparing rainbow trout and carp hepatocytes

in In Vitro Toxicology

Ina Bischof
Jon A. Arnot
Heinrich Jürling
Georg Knipschild
Christian Schlechtriem
Anna Schauerte
Helmut Segner

Frontiers in Toxicology

doi 10.3389/ftox.2022.1021880

2,598 views
2 citations

Perspective

Published on 09 Sep 2022

Use of new approach methodologies (NAMs) to meet regulatory requirements for the assessment of tobacco and other nicotine-containing products

in In Vitro Toxicology

Jacqueline Miller-Holt
Holger P. Behrsing
Amy J. Clippinger
Carole Hirn
Todd J. Stedeford
Andreas O. Stucki

Frontiers in Toxicology

doi 10.3389/ftox.2022.943358

5,401 views
11 citations

Review

Published on 01 Sep 2022

Use of new approach methodologies (NAMs) to meet regulatory requirements for the assessment of industrial chemicals and pesticides for effects on human health

in In Vitro Toxicology

Andreas O. Stucki
Tara S. Barton-Maclaren
Yadvinder Bhuller
Joseph E. Henriquez
Tala R. Henry
Carole Hirn
Jacqueline Miller-Holt
Edith G. Nagy
Monique M. Perron
Deborah E. Ratzlaff

Frontiers in Toxicology

doi 10.3389/ftox.2022.964553

38,610 views
169 citations

Original Research

Published on 22 Aug 2022

Dynamic Mass Balance Modeling for Chemical Distribution Over Time in In Vitro Systems With Repeated Dosing

in In Vitro Toxicology

Sherri Bloch
Jon A. Arnot
Nynke I. Kramer
James M. Armitage
Marc-André Verner

Frontiers in Toxicology

doi 10.3389/ftox.2022.911128

2,802 views
3 citations

Original Research

Published on 05 Aug 2022

Congeners-Specific Intestinal Absorption Of Microcystins In An In Vitro 3D Human Intestinal Epithelium: The Role Of Influx/Efflux Transporters

in In Vitro Toxicology

Laura Turco
Nicoletta Santori
Franca M. Buratti
Jean-Lou C. M. Dorne
Emanuela Testai

Frontiers in Toxicology

doi 10.3389/ftox.2022.883063

2,556 views
3 citations

Original Research

Published on 18 Jul 2022

In Vitro–In Vivo Extrapolation by Physiologically Based Kinetic Modeling: Experience With Three Case Studies and Lessons Learned

in In Vitro Toxicology

Engi Abdelhady Algharably
Emma Di Consiglio
Emanuela Testai
Francesca Pistollato
Hans Mielke
Ursula Gundert-Remy

Frontiers in Toxicology

doi 10.3389/ftox.2022.885843

6,961 views
10 citations

Original Research

Published on 17 Jun 2022

A New Immortalized Human Alveolar Epithelial Cell Model to Study Lung Injury and Toxicity on a Breathing Lung-On-Chip System

in In Vitro Toxicology

Arunima Sengupta
Nuria Roldan
Mirjam Kiener
Laurène Froment
Giulia Raggi
Theo Imler
Lea de Maddalena
Aude Rapet
Tobias May
Patrick Carius

Frontiers in Toxicology

doi 10.3389/ftox.2022.840606

14,744 views
41 citations

Original Research

Published on 15 Jun 2022

Mapping Adverse Outcome Pathways for Kidney Injury as a Basis for the Development of Mechanism-Based Animal-Sparing Approaches to Assessment of Nephrotoxicity

in In Vitro Toxicology

Angela Mally
Sebastian Jarzina

Frontiers in Toxicology

doi 10.3389/ftox.2022.863643

3,552 views
6 citations

Original Research

Published on 06 Jun 2022

Accurate Evaluation of Hepatocyte Metabolisms on a Noble Oxygen-Permeable Material With Low Sorption Characteristics

in In Vitro Toxicology

Masaki Nishikawa
Hiroyasu Ito
Fumiya Tokito
Keita Hirono
Kousuke Inamura
Benedikt Scheidecker
Mathieu Danoy
Takumi Kawanishi
Hirohsi Arakawa
Yukio Kato

Frontiers in Toxicology

doi 10.3389/ftox.2022.810478

4,062 views
14 citations

Original Research

Published on 02 Jun 2022

Next Generation Risk Assessment of the Anti-Androgen Flutamide Including the Contribution of Its Active Metabolite Hydroxyflutamide

in In Vitro Toxicology

Tessa C.A. van Tongeren
Paul L. Carmichael
Ivonne M.C.M. Rietjens
Hequn Li

Frontiers in Toxicology

doi 10.3389/ftox.2022.881235

3,787 views
2 citations

Original Research

Published on 02 May 2022

Application of Defined Approaches for Skin Sensitization to Agrochemical Products

in In Vitro Toxicology

Judy Strickland
James Truax
Marco Corvaro
Raja Settivari
Joseph Henriquez
Jeremy McFadden
Travis Gulledge
Victor Johnson
Sean Gehen
Dori Germolec

Frontiers in Toxicology

doi 10.3389/ftox.2022.852856

10,831 views
22 citations

Original Research

Published on 02 May 2022

Cytotoxicity of Medicinal Plant Species Used by Traditional Healers in Treating People Suffering From HIV/AIDS in Uganda

in In Vitro Toxicology

Godwin Upoki Anywar
Esezah Kakudidi
Hannington Oryem-Origa
Andreas Schubert
Christian Jassoy

Frontiers in Toxicology

doi 10.3389/ftox.2022.832780

12,654 views
30 citations

Review

Published on 29 Apr 2022

Considerations for Improving Metabolism Predictions for In Vitro to In Vivo Extrapolation

in In Vitro Toxicology

Marjory Moreau
Pankajini Mallick
Marci Smeltz
Saad Haider
Chantel I. Nicolas
Salil N. Pendse
Jeremy A. Leonard
Matthew W. Linakis
Patrick D. McMullen
Rebecca A. Clewell

Frontiers in Toxicology

doi 10.3389/ftox.2022.894569

3,676 views
12 citations

Original Research

Published on 28 Apr 2022

A Case Study on Integrating a New Key Event Into an Existing Adverse Outcome Pathway on Oxidative DNA Damage: Challenges and Approaches in a Data-Rich Area

in In Vitro Toxicology

Elizabeth Huliganga
Francesco Marchetti
Jason M. O’Brien
Vinita Chauhan
Carole L. Yauk

Frontiers in Toxicology

doi 10.3389/ftox.2022.827328

2,989 views
2 citations

Original Research

Published on 19 Apr 2022

Application of the Adverse Outcome Pathway Concept to In Vitro Nephrotoxicity Assessment: Kidney Injury due to Receptor-Mediated Endocytosis and Lysosomal Overload as a Case Study

in In Vitro Toxicology

Sebastian Jarzina
Stefano Di Fiore
Bernhard Ellinger
Pia Reiser
Sabrina Frank
Markus Glaser
Jiaqing Wu
Femke J. Taverne
Nynke I. Kramer
Angela Mally

Frontiers in Toxicology

doi 10.3389/ftox.2022.864441

8,613 views
8 citations

Perspective

Published on 30 Mar 2022

From Qualitative to Quantitative AOP: A Case Study of Neurodegeneration

in In Vitro Toxicology

Dennis Sinitsyn
Natàlia Garcia-Reyero
Karen H. Watanabe

Frontiers in Toxicology

doi 10.3389/ftox.2022.838729

3,236 views
9 citations