Frontiers in Toxicology | Regulatory Toxicology

Original Research

Accepted on 09 Feb 2026

Protective Effects of Lagerstroemia speciosa Against Paracetamol-Induced Renal and Testicular Toxicity in Rats via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Mechanisms

in Regulatory Toxicology

Nagham E. Elsheshtawy
Engy Risha
Fatma M. Abdelhamid
Bodour Rajab
Rehab Bagadood
Bayan Bokhari
Ghadir Sindi
Ahmed I. Ateya
Shimaa Rezk
Mohamed El-Boshy

Frontiers in Toxicology

181 views

Original Research

Accepted on 30 Jan 2026

Perspectives on Variability of In Vivo Toxicology Studies: Considerations for Next-generation Toxicology

in Regulatory Toxicology

Agnes L Karmaus
Anna L Kreutz
Oluwakemi Oyetade
Katie Paul Friedman
Martin Paparella
Emily N Reinke
David Allen
Helena Therese Hogberg
Nicole C Kleinstreuer

Frontiers in Toxicology

265 views

Perspective

Published on 15 Jan 2026

Risk assessment of metals measured in regulated Canadian dried cannabis and cannabis vaping products: case study and perspectives

in Regulatory Toxicology

Sathish Achuthan
Andrew Waye
Hanan Abramovici

Frontiers in Toxicology

doi 10.3389/ftox.2025.1755875

1,434 views

Perspective

Published on 15 Jan 2026

A user-informed perspective of the toxicological data gap in India’s cannabis landscape

in Regulatory Toxicology

Muzafar Riyaz

Frontiers in Toxicology

doi 10.3389/ftox.2025.1734313

645 views

Review

Published on 17 Dec 2025

Mechanistic read-across comes of age: a comparative appraisal of EFSA 2025 guidance, ECHA’s RAAF, and good read-across practice

in Regulatory Toxicology

Thomas Hartung
Costanza Rovida

Frontiers in Toxicology

doi 10.3389/ftox.2025.1690491

2,002 views
1 citation

Original Research

Published on 05 Nov 2025

Rodent home cage monitoring for preclinical safety pharmacology assessment: results of a multi-company validation evaluating nonclinical and clinical data from three compounds

in Regulatory Toxicology

R. R. Sillito
J. Sutherland
A. Milne
C. Giuliano
C. Sigfridsson
M. Rolf
A. K. Cherian
M. McClafferty
E. I. Rossman
G. Teuns

Frontiers in Toxicology

doi 10.3389/ftox.2025.1655330

3,340 views

Original Research

Published on 08 Oct 2025

Reproduction of the human relevant potency threshold (HRPT) for estrogen receptor alpha agonism in an inference performance screen for ICCVAM’s regulatory scientific confidence framework

in Regulatory Toxicology

Jessica Ryman
Richard A. Becker

Frontiers in Toxicology

doi 10.3389/ftox.2025.1657708

1,880 views

Original Research

Published on 15 Sep 2025

Error-corrected next-generation sequencing mutagenicity assays in human HepaRG cells as human-relevant genetic toxicology new approach methodology

in Regulatory Toxicology

A. Rasim Barutcu
Nimisha Bhattarai
Raymond Samuel
Jamie Scaglione
Leslie Recio

Frontiers in Toxicology

doi 10.3389/ftox.2025.1657189

2,624 views
1 citation

Original Research

Published on 11 Aug 2025

Assessment of heated herbal products’ tobacco harm reduction potential: pre‐clinical and clinical studies

in Regulatory Toxicology

Alvaro-Flavio Marinas-Lacasta
Ian M. Fearon
Matthew Stevenson
Tasnim Abusalem
Fiona Chapman
Edgar Trelles Sticken
Roman Wieczorek
Sarah Jean Pour
Ole Dethloff
Ourania Komini

Frontiers in Toxicology

doi 10.3389/ftox.2025.1589480

4,702 views

Original Research

Published on 04 Aug 2025

Refinement of a workflow for human relevance assessment of adverse outcome pathways and associated new approach methodologies

in Regulatory Toxicology

Annick D. van den Brand
Julia J. Meerman
Christina H. J. Veltman
Mirjam Luijten

Frontiers in Toxicology

doi 10.3389/ftox.2025.1616817

2,067 views

Perspective

Published on 17 Jul 2025

Stress convulsions in rodents: within a weight-of-evidence framework for human seizure risk

in Regulatory Toxicology

Joseph J. DeGeorge
Monica R. Metea

Frontiers in Toxicology

doi 10.3389/ftox.2025.1600816

1,915 views

Original Research

Published on 04 Jun 2025

Characterization of medical device constituents and development of duration-based non-cancer threshold of toxicological concern values

in Regulatory Toxicology

Taylor Builee
Todd A. Kennedy
Valériane Levelut
Megan A. Hahn
Stephen Bond
Michael K. Peterson
Frances K. Hsia
Alessia Stornetta
Kristin J. Erickson
Kimberly D. Ehman

Frontiers in Toxicology

doi 10.3389/ftox.2025.1600127

6,934 views
1 citation

Mini Review

Published on 14 May 2025

Optimizing Wnt activation in fetal calf serum (FCS)-free organoid expansion media

in Regulatory Toxicology

Esther J. M. Liefting
Jeffrey J. Bajramovic

Frontiers in Toxicology

doi 10.3389/ftox.2025.1504469

2,669 views
2 citations

Original Research

Published on 14 Mar 2025

Selection of the critical effect size alters hazard characterization – a retrospective analysis of key studies used for risk assessments of PFAS

in Regulatory Toxicology

L. Brunken
A. Vieira Silva
M. Öberg

Frontiers in Toxicology

doi 10.3389/ftox.2025.1525089

2,621 views

Perspective

Published on 15 Jan 2025

Young TPI: empowering animal-free science among the next- generation of scientists

in Regulatory Toxicology

Marta G. Valverde
Fatima Zohra Abarkan
Rebecca Van Eijden
Julia M. L. Menon
Nikolas Gaio
Aarti Ramchandran
Victoria C. De Leeuw

Frontiers in Toxicology

doi 10.3389/ftox.2024.1521317

17,335 views

Editorial

Published on 10 Jan 2025

Editorial: Emerging topics on chemical safety assessment

in Regulatory Toxicology

Maricel V. Maffini
Laura N. Vandenberg

Frontiers in Toxicology

doi 10.3389/ftox.2024.1542469

2,456 views
1 citation

Editorial

Published on 18 Dec 2024

Editorial: Reducing animal use in carcinogenicity testing

in Regulatory Toxicology

Jan Willem Van der Laan
Joseph Manuppello

Frontiers in Toxicology

doi 10.3389/ftox.2024.1538905

1,426 views
1 citation

Perspective

Published on 06 Dec 2024

Considering future qualification for regulatory science in the early development of microphysiological systems: a case study of microthrombosis in a Vessel-on-Chip

in Regulatory Toxicology

Huub J. Weener
Heleen H. T. Middelkamp
Andries D. Van der Meer

Frontiers in Toxicology

doi 10.3389/ftox.2024.1513002

2,759 views
3 citations

Original Research

Published on 01 Nov 2024

Identifying non-essential uses to phase out substances of very high concern under REACH

in Regulatory Toxicology

Flora Borchert
Romain Figuière
Ian T. Cousins
Christina Rudén
Marlene Ågerstrand

Frontiers in Toxicology

doi 10.3389/ftox.2024.1488336

4,317 views

Original Research

Published on 03 Oct 2024

Fulfilling the criteria for CLP classification: the implications for substances under the EU chemicals legislation

in Regulatory Toxicology

Diana Kättström
Anna Beronius
Urban Boije af Gennäs
Christina Rudén
Marlene Ågerstrand

Frontiers in Toxicology

doi 10.3389/ftox.2024.1452065

4,185 views
1 citation

Brief Research Report

Published on 02 Oct 2024

Neonicotinoid pesticides: evidence of developmental neurotoxicity from regulatory rodent studies

in Regulatory Toxicology

Jennifer Beth Sass
Nathan Donley
William Freese

Frontiers in Toxicology

doi 10.3389/ftox.2024.1438890

12,251 views
9 citations

Perspective

Published on 24 Sep 2024

Potential mammary carcinogens used in food contact articles: implications for policy, enforcement, and prevention

in Regulatory Toxicology

Lindsey V. Parkinson
Birgit Geueke
Jane Muncke

Frontiers in Toxicology

doi 10.3389/ftox.2024.1440331

26,670 views
2 citations

Review

Published on 18 Sep 2024

Overview of human health effects related to glyphosate exposure

in Regulatory Toxicology

Flavia Silvia Galli
Marta Mollari
Valentina Tassinari
Cristian Alimonti
Alessandro Ubaldi
Camilla Cuva
Daniele Marcoccia

Frontiers in Toxicology

doi 10.3389/ftox.2024.1474792

30,510 views
39 citations

Data Report

Published on 17 Sep 2024

A new database contains 520 studies investigating the carcinogenicity data of 238 pharmaceuticals across 14 ATC classifications

in Regulatory Toxicology

Panagiotis G. Karamertzanis
Martina Evangelisti
Marco Daniele Parenti
Jochen vom Brocke
Alberto Del Rio
Ingo Bichlmaier

Frontiers in Toxicology

doi 10.3389/ftox.2024.1450612

2,845 views