Frontiers in Toxicology | Regulatory Toxicology

Perspective

Published on 23 May 2024

ICH S1 prospective evaluation study and weight of evidence assessments: commentary from industry representatives

in Regulatory Toxicology

John L. Vahle
Joe Dybowski
Michael Graziano
Shigeru Hisada
Jose Lebron
Thomas Nolte
Ronald Steigerwalt
Kenjiro Tsubota
Frank D. Sistare

Frontiers in Toxicology

doi 10.3389/ftox.2024.1377990

2,117 views
1 citation

Original Research

Published on 11 Apr 2024

ICH S1 prospective evaluation study: weight of evidence approach to predict outcome and value of 2-year rat carcinogenicity studies. A report from the regulatory authorities subgroup

in Regulatory Toxicology

Todd Bourcier
Timothy McGovern
Tania Cavaliero
Geoffrey Ebere
Akiyoshi Nishikawa
Jihei Nishimura
Kumiko Ogawa
Markku Pasanen
Alisa Vespa
Jan Willem Van der Laan

Frontiers in Toxicology

doi 10.3389/ftox.2024.1353783

4,230 views
4 citations

Policy and Practice Reviews

Published on 05 Apr 2024

Developing a pragmatic consensus procedure supporting the ICH S1B(R1) weight of evidence carcinogenicity assessment

in Regulatory Toxicology

Arianna Bassan
Ronald Steigerwalt
Douglas Keller
Lisa Beilke
Paul M. Bradley
Frank Bringezu
William J. Brock
Leigh Ann Burns-Naas
Jon Chambers
Kevin Cross

Frontiers in Toxicology

doi 10.3389/ftox.2024.1370045

2,766 views
1 citation

Original Research

Published on 26 Mar 2024

Building an adverse outcome pathway network for estrogen-, androgen- and steroidogenesis-mediated reproductive toxicity

in Regulatory Toxicology

Johanna Zilliacus
Monica K. Draskau
Hanna K. L. Johansson
Terje Svingen
Anna Beronius

Frontiers in Toxicology

doi 10.3389/ftox.2024.1357717

1,847 views
4 citations

Review

Published on 25 Mar 2024

Challenging the status quo: a framework for mechanistic and human-relevant cardiovascular safety screening

in Regulatory Toxicology

Brian Berridge
Jennifer Pierson
Syril Pettit
Norman Stockbridge

Frontiers in Toxicology

doi 10.3389/ftox.2024.1352783

1,837 views
1 citation

Editorial

Published on 15 Mar 2024

Editorial: Human biomonitoring (HBM) as a tool to support policy and regulatory action to prevent chemicals exposure

in Regulatory Toxicology

Susana Viegas
Carla Martins
Ricardo Assunção

Frontiers in Toxicology

doi 10.3389/ftox.2024.1376890

748 views

Original Research

Published on 08 Mar 2024

Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps

in Regulatory Toxicology

Thomas Jaylet
Thibaut Coustillet
Nicola M. Smith
Barbara Viviani
Birgitte Lindeman
Lucia Vergauwen
Oddvar Myhre
Nurettin Yarar
Johanna M. Gostner
Pablo Monfort-Lanzas

Frontiers in Toxicology

doi 10.3389/ftox.2024.1285768

4,643 views
5 citations

Review

Published on 10 Jan 2024

Brain-derived neurotrophic factor (BDNF): an effect biomarker of neurodevelopment in human biomonitoring programs

in Regulatory Toxicology

Andrea Rodríguez-Carrillo
Veerle J. Verheyen
Alexander L. N. Van Nuijs
Mariana F. Fernández
Sylvie Remy

Frontiers in Toxicology

doi 10.3389/ftox.2023.1319788

3,931 views
1 citation

Review

Published on 08 Jan 2024

The “Big Three” in biocompatibility testing of medical devices: implementation of alternatives to animal experimentation—are we there yet?

in Regulatory Toxicology

Helena Kanďárová
Peter Pôbiš

Frontiers in Toxicology

doi 10.3389/ftox.2023.1337468

16,530 views
9 citations

Review

Published on 19 Dec 2023

Metabolites in the regulatory risk assessment of pesticides in the EU

in Regulatory Toxicology

Olavi Pelkonen
Khaled Abass
Juan Manuel Parra Morte
Martina Panzarea
Emanuela Testai
Serge Rudaz
Jochem Louisse
Ursula Gundert-Remy
Gerrit Wolterink
Dorne Jean-Lou CM

Frontiers in Toxicology

doi 10.3389/ftox.2023.1304885

3,437 views
4 citations

Original Research

Published on 08 Dec 2023

Prediction and assessment of xenoestrogens mixture effects using the in vitro ERα-CALUX assay

in Regulatory Toxicology

Marc Elskens
Imke Boonen
Steven Eisenreich

Frontiers in Toxicology

doi 10.3389/ftox.2023.1252847

2,167 views
2 citations

Review

Published on 17 Nov 2023

Advancing food safety risk assessment in China: development of new approach methodologies (NAMs)

in Regulatory Toxicology

Daoyuan Yang
Hui Yang
Miaoying Shi
Xudong Jia
Haixia Sui
Zhaoping Liu
Yongning Wu

Frontiers in Toxicology

doi 10.3389/ftox.2023.1292373

5,910 views
2 citations

Original Research

Published on 17 Nov 2023

SciRAPnano: a pragmatic and harmonized approach for quality evaluation of in vitro toxicity data to support risk assessment of nanomaterials

in Regulatory Toxicology

Gen Shao
Anna Beronius
Penny Nymark

Frontiers in Toxicology

doi 10.3389/ftox.2023.1319985

1,529 views
2 citations

Original Research

Published on 13 Nov 2023

In silico approaches in carcinogenicity hazard assessment: case study of pregabalin, a nongenotoxic mouse carcinogen

in Regulatory Toxicology

Douglas A. Keller
Arianna Bassan
Alexander Amberg
Leigh Ann Burns Naas
Jon Chambers
Kevin Cross
Frances Hall
Gloria D. Jahnke
Amarjit Luniwal
Serena Manganelli

Frontiers in Toxicology

doi 10.3389/ftox.2023.1234498

3,262 views
1 citation

Original Research

Published on 04 Jul 2023

Longitudinal characterization of TK6 cells sequentially adapted to animal product-free, chemically defined culture medium: considerations for genotoxicity studies

in Regulatory Toxicology

Noelia Perez-Diaz
Ewelina Hoffman
Julie Clements
Rebecca Cruickshank
Ann Doherty
Daniel Ebner
Joanne Elloway
Jianan Fu
Joanne Kelsall
Val Millar

Frontiers in Toxicology

doi 10.3389/ftox.2023.1177586

2,417 views
1 citation

Methods

Published on 05 Jun 2023

FAIR environmental and health registry (FAIREHR)- supporting the science to policy interface and life science research, development and innovation

in Regulatory Toxicology

Maryam Zare Jeddi
Karen S. Galea
Susana Viegas
Peter Fantke
Henriqueta Louro
Jan Theunis
Eva Govarts
Sébastien Denys
Clémence Fillol
Loïc Rambaud

Frontiers in Toxicology

doi 10.3389/ftox.2023.1116707

3,541 views
1 citation

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Articles

ICH S1 prospective evaluation study and weight of evidence assessments: commentary from industry representatives

ICH S1 prospective evaluation study: weight of evidence approach to predict outcome and value of 2-year rat carcinogenicity studies. A report from the regulatory authorities subgroup

Developing a pragmatic consensus procedure supporting the ICH S1B(R1) weight of evidence carcinogenicity assessment

Building an adverse outcome pathway network for estrogen-, androgen- and steroidogenesis-mediated reproductive toxicity

Challenging the status quo: a framework for mechanistic and human-relevant cardiovascular safety screening

Editorial: Human biomonitoring (HBM) as a tool to support policy and regulatory action to prevent chemicals exposure

Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps

Brain-derived neurotrophic factor (BDNF): an effect biomarker of neurodevelopment in human biomonitoring programs

The “Big Three” in biocompatibility testing of medical devices: implementation of alternatives to animal experimentation—are we there yet?

Metabolites in the regulatory risk assessment of pesticides in the EU

Prediction and assessment of xenoestrogens mixture effects using the in vitro ERα-CALUX assay

Advancing food safety risk assessment in China: development of new approach methodologies (NAMs)

SciRAPnano: a pragmatic and harmonized approach for quality evaluation of in vitro toxicity data to support risk assessment of nanomaterials

In silico approaches in carcinogenicity hazard assessment: case study of pregabalin, a nongenotoxic mouse carcinogen

Longitudinal characterization of TK6 cells sequentially adapted to animal product-free, chemically defined culture medium: considerations for genotoxicity studies

FAIR environmental and health registry (FAIREHR)- supporting the science to policy interface and life science research, development and innovation