Frontiers in Toxicology | Regulatory Toxicology

Original Research

Published on 16 Sep 2024

The use of in vitro bioassays and chemical screening to assess the impact of a minimally processed vegetable facility on wastewater quality

in Regulatory Toxicology

N. H. Aneck-Hahn
M. C. Van Zijl
L. Quinn
C. Swiegelaar
N. Nhlapo
W. de Bruin
L. Korsten

Frontiers in Toxicology

doi 10.3389/ftox.2024.1439126

1,422 views

Original Research

Published on 13 Sep 2024

Glyphosate and a glyphosate-based herbicide dysregulate the epigenetic landscape of Homeobox A10 (Hoxa10) gene during the endometrial receptivity in Wistar rats

in Regulatory Toxicology

Virginia Lorenz
Florencia Doná
Dalma B. Cadaviz
María M. Milesi
Jorgelina Varayoud

Frontiers in Toxicology

doi 10.3389/ftox.2024.1438826

1,932 views

Opinion

Published on 13 Aug 2024

Science evolves but outdated testing and static risk management in the US delay protection to human health

in Regulatory Toxicology

Maricel V. Maffini
Laura N. Vandenberg

Frontiers in Toxicology

doi 10.3389/ftox.2024.1444024

2,460 views

Original Research

Published on 24 Jul 2024

Characterization of a human thyroid microtissue model for testing thyroid disrupting chemicals

in Regulatory Toxicology

E. Rogers
E. K. Breathwaite
T. Nguyen-Jones
S. M. Anderson
J. J. Odanga
D. T. Parks
K. K. Wolf
T. Stone
P. Balbuena
J. Chen

Frontiers in Toxicology

doi 10.3389/ftox.2024.1408808

1,747 views

Policy and Practice Reviews

Published on 12 Jun 2024

Assessing human carcinogenicity risk of agrochemicals without the rodent cancer bioassay

in Regulatory Toxicology

Amber Goetz
Natalia Ryan
Alaina Sauve-Ciencewicki
Caleb C. Lord
Gina M. Hilton
Douglas C. Wolf

Frontiers in Toxicology

doi 10.3389/ftox.2024.1394361

2,412 views

Perspective

Published on 23 May 2024

ICH S1 prospective evaluation study and weight of evidence assessments: commentary from industry representatives

in Regulatory Toxicology

John L. Vahle
Joe Dybowski
Michael Graziano
Shigeru Hisada
Jose Lebron
Thomas Nolte
Ronald Steigerwalt
Kenjiro Tsubota
Frank D. Sistare

Frontiers in Toxicology

doi 10.3389/ftox.2024.1377990

3,152 views
2 citations

Original Research

Published on 11 Apr 2024

ICH S1 prospective evaluation study: weight of evidence approach to predict outcome and value of 2-year rat carcinogenicity studies. A report from the regulatory authorities subgroup

in Regulatory Toxicology

Todd Bourcier
Timothy McGovern
Tania Cavaliero
Geoffrey Ebere
Akiyoshi Nishikawa
Jihei Nishimura
Kumiko Ogawa
Markku Pasanen
Alisa Vespa
Jan Willem Van der Laan

Frontiers in Toxicology

doi 10.3389/ftox.2024.1353783

5,432 views
6 citations

Policy and Practice Reviews

Published on 05 Apr 2024

Developing a pragmatic consensus procedure supporting the ICH S1B(R1) weight of evidence carcinogenicity assessment

in Regulatory Toxicology

Arianna Bassan
Ronald Steigerwalt
Douglas Keller
Lisa Beilke
Paul M. Bradley
Frank Bringezu
William J. Brock
Leigh Ann Burns-Naas
Jon Chambers
Kevin Cross

Frontiers in Toxicology

doi 10.3389/ftox.2024.1370045

3,899 views
5 citations

Original Research

Published on 26 Mar 2024

Building an adverse outcome pathway network for estrogen-, androgen- and steroidogenesis-mediated reproductive toxicity

in Regulatory Toxicology

Johanna Zilliacus
Monica K. Draskau
Hanna K. L. Johansson
Terje Svingen
Anna Beronius

Frontiers in Toxicology

doi 10.3389/ftox.2024.1357717

2,515 views
8 citations

Review

Published on 25 Mar 2024

Challenging the status quo: a framework for mechanistic and human-relevant cardiovascular safety screening

in Regulatory Toxicology

Brian Berridge
Jennifer Pierson
Syril Pettit
Norman Stockbridge

Frontiers in Toxicology

doi 10.3389/ftox.2024.1352783

2,269 views
1 citation

Editorial

Published on 15 Mar 2024

Editorial: Human biomonitoring (HBM) as a tool to support policy and regulatory action to prevent chemicals exposure

in Regulatory Toxicology

Susana Viegas
Carla Martins
Ricardo Assunção

Frontiers in Toxicology

doi 10.3389/ftox.2024.1376890

942 views
1 citation

Original Research

Published on 08 Mar 2024

Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps

in Regulatory Toxicology

Thomas Jaylet
Thibaut Coustillet
Nicola M. Smith
Barbara Viviani
Birgitte Lindeman
Lucia Vergauwen
Oddvar Myhre
Nurettin Yarar
Johanna M. Gostner
Pablo Monfort-Lanzas

Frontiers in Toxicology

doi 10.3389/ftox.2024.1285768

6,543 views
9 citations

Review

Published on 10 Jan 2024

Brain-derived neurotrophic factor (BDNF): an effect biomarker of neurodevelopment in human biomonitoring programs

in Regulatory Toxicology

Andrea Rodríguez-Carrillo
Veerle J. Verheyen
Alexander L. N. Van Nuijs
Mariana F. Fernández
Sylvie Remy

Frontiers in Toxicology

doi 10.3389/ftox.2023.1319788

5,449 views
6 citations

Review

Published on 08 Jan 2024

The “Big Three” in biocompatibility testing of medical devices: implementation of alternatives to animal experimentation—are we there yet?

in Regulatory Toxicology

Helena Kanďárová
Peter Pôbiš

Frontiers in Toxicology

doi 10.3389/ftox.2023.1337468

22,938 views
29 citations

Review

Published on 19 Dec 2023

Metabolites in the regulatory risk assessment of pesticides in the EU

in Regulatory Toxicology

Olavi Pelkonen
Khaled Abass
Juan Manuel Parra Morte
Martina Panzarea
Emanuela Testai
Serge Rudaz
Jochem Louisse
Ursula Gundert-Remy
Gerrit Wolterink
Dorne Jean-Lou CM

Frontiers in Toxicology

doi 10.3389/ftox.2023.1304885

4,714 views
5 citations

Original Research

Published on 08 Dec 2023

Prediction and assessment of xenoestrogens mixture effects using the in vitro ERα-CALUX assay

in Regulatory Toxicology

Marc Elskens
Imke Boonen
Steven Eisenreich

Frontiers in Toxicology

doi 10.3389/ftox.2023.1252847

2,702 views
3 citations