Frontiers in Toxicology

Review

Published on 17 Dec 2025

Mechanistic read-across comes of age: a comparative appraisal of EFSA 2025 guidance, ECHA’s RAAF, and good read-across practice

Thomas Hartung
Costanza Rovida

Frontiers in Toxicology

doi 10.3389/ftox.2025.1690491

1,969 views
1 citation

Correction

Published on 16 Dec 2025

Correction: The impact of perfumes and cosmetic products on human health: a narrative review

Sharifa Alblooshi

Frontiers in Toxicology

doi 10.3389/ftox.2025.1713750

1,512 views

Review

Published on 10 Dec 2025

Enhancing allergenicity risk assessment for novel foods in the EU: insights from the updated EFSA guidance - requirements, knowledge gaps and research needs

Marcello Laganaro
Anna-Maria Pieger
Alejandra Muñoz-González
Estefanía Noriega Fernández
Ermolaos Ververis
Andrea Germini
Antonio Fernández Dumont

Frontiers in Toxicology

doi 10.3389/ftox.2025.1701391

2,006 views
1 citation

Original Research

Published on 08 Dec 2025

Comparative evaluation of artificial saliva and complete artificial saliva as solvent vehicles for in vitro toxicity testing of oral tobacco products

Xuefei Cao
Mariana T. Farcas
Yevgeniya V. Prepelitskaya
Abaigeal Ritzenthaler
Jennifer Molignano
Jonathan Oldach
Marisol M. Gutierrez

Frontiers in Toxicology

doi 10.3389/ftox.2025.1657073

1,548 views

Case Report

Published on 05 Dec 2025

Cortical microstructural change linked to clinical recovery in subacute delayed encephalopathy after acute carbon monoxide poisoning: a longitudinal case report

Takehiro Tamura
Yuka Fujimoto
Hironobu Nakamura
Yuki Takahashi
Junya Fujino
Shunsuke Takagi
Hidehiko Takahashi
Genichi Sugihara

Frontiers in Toxicology

doi 10.3389/ftox.2025.1701308

988 views

Original Research

Published on 05 Dec 2025

Thai rice instant granules containing turmeric extract and Phyllanthus emblica fruit pulp: Chronic toxicity and antioxidant profiles in rats and in silico investigation of bioactive compounds

Charatda Punvittayagul
Atigan Thongtharb
Sonthaya Umsumarng
Siripat Chaichit
Siriporn Okonogi
Chadarat Ampasavate
Darunee Hongwiset
Sirinya Taya

Frontiers in Toxicology

doi 10.3389/ftox.2025.1691014

1,052 views

Data Report

Published on 05 Dec 2025

Wild mushroom poisoning in Mengzi city, Yunnan province, China, 2018–2023: an analysis through epidemiological characteristics and time series analysis with SARIMA and holt-winters models

Rong Niu
Yimin Wang

Frontiers in Toxicology

doi 10.3389/ftox.2025.1705460

1,224 views

Original Research

Published on 04 Dec 2025

Monocyte migration assay using a vascular-on-a-chip model and its utilization for the evaluation of a heated tobacco product

Ayaka Hayashida
Atsuko Nozawa
Shigeaki Ito

Frontiers in Toxicology

doi 10.3389/ftox.2025.1658093

1,601 views

Original Research

Published on 04 Dec 2025

Simulation of microplastic transport and dispersion based on a three-dimensional hydrodynamic particle-tracking model in the Beibu Gulf

Changhao Sun
Yao Guan
Wenhao Hou
Huihua Wei
Xiaowei Hu
Huichang Jiang
Qiongyuan Su
Xiong Zhou
Jie Chen
Zuhao Zhu

Frontiers in Toxicology

doi 10.3389/ftox.2025.1676823

1,086 views

Original Research

Published on 03 Dec 2025

Retrospective analysis of clinical laboratory parameters in Han Wistar rat controls

Rupert Kellner
Alexander Amberg
Frank Bringezu
Dragomir Ivanov Draganov
Annika Kreuchwig
Wolfgang Muster
Guillemette Duchateau-Nguyen
Nils Oberhauser
Paolo Piraino
Markus Schaefer

Frontiers in Toxicology

doi 10.3389/ftox.2025.1684191

1,004 views

Review

Published on 02 Dec 2025

Advancements in the in vitro culture of human pluripotent stem cells: progress, challenges, and future directions: comprehensive review

Niraj Chaudhary
Luis G. Villa-Diaz

Frontiers in Toxicology

doi 10.3389/ftox.2025.1667573

1,896 views

Original Research

Published on 27 Nov 2025

Unseen contaminants in Portuguese reservoirs: linking microplastics to ecological potential and human pressures

C. Guimarães
I. Pinto
J. A. Padilha
S. C. Antunes

Frontiers in Toxicology

doi 10.3389/ftox.2025.1705228

1,141 views

Original Research

Published on 27 Nov 2025

Hazard identification and characterization of leachable chemicals from plastic products – a new PARC project

Hubert Dirven
Aleksandra Bogusz
Hans Bouwmeester
Mathias Busch
Guillaume Duflos
Gunnar S. Eriksen
Margarida Fardilha
Daniela Flores-Gomez
Nina Franko
Laurent Gaté

Frontiers in Toxicology

doi 10.3389/ftox.2025.1719035

2,678 views

Original Research

Published on 26 Nov 2025

AlCl3 exposure induces nephrotoxicity in mice by mediating ferroptosis through the NRF2 signaling pathway

Liu-Dan Liang
Xiao-Yue Zhao
Li Li
Sheng Liang
Jin-Min Zhang
Jian-Nan Lv
Feng-Lian Deng
Chun-Lei Lu
Qian Li
Qi-Wen Huang

Frontiers in Toxicology

doi 10.3389/ftox.2025.1692410

1,376 views

Original Research

Published on 24 Nov 2025

Cadmium and glyphosate jointly compromise sperm function, fertilization, and early development in Prochilodus magdalenae

Jose Espinosa-Araujo
Lucellys Sierra-Marquez
Victor Atencio-Garcia
Jesus Olivero-Verbel

Frontiers in Toxicology

doi 10.3389/ftox.2025.1698489

1,113 views

Systematic Review

Published on 24 Nov 2025

Endocrine disruption rewards: bisphenol-A-induced reproductive toxicity and the precision ameliorative potential of flavonoids in preclinical studies. A systematic review and meta-analysis

Michael Ben Okon
Ilemobayo Victor Fasogbon
Dominic Swase
Reuben Samson Dangana
Wusa Makena
Vivian Onyinye Ojiakor
Ekom Monday Etukudo
Joan Chebet
Angela Mumbua Musyoka
Sandra Etumah Ifie

Frontiers in Toxicology

doi 10.3389/ftox.2025.1687862

1,877 views

Original Research

Published on 20 Nov 2025

Nose-to-brain translocation of inhaled ultrafine elongated particles: facts and mysteries

U. M. Graham
J. M. Pinto
J. Weuve
A. K. Dozier
R. Rogers
S. Nag
J. Schneider
J. D. Kaufman
D. A. Bennett
G. Oberdörster

Frontiers in Toxicology

doi 10.3389/ftox.2025.1655149

2,434 views
5 citations

Original Research

Published on 20 Nov 2025

A new type of ultrasonic water alleviates constipation with favorable safety

Jiarong Hu
Xinyi Hu
Wenjie Huang
Fen Wang
Zhongqi Xia
Chenyang Zhu
Junwei Chow
Shiwei Yan
Longzhou Li
Haiyang Liu

Frontiers in Toxicology

doi 10.3389/ftox.2025.1679872

1,117 views

Review

Published on 20 Nov 2025

Overall effects of microplastics on brain

Su-jun Fang
Zhao-di Yin
Li-fan Li
Qi Cai
Peng-fei Zheng
Li-zhen Chen

Frontiers in Toxicology

doi 10.3389/ftox.2025.1619096

4,078 views
1 citation

Original Research

Published on 19 Nov 2025

Decoding PFAS immunotoxicity: a NAMs-based comparison of short vs. long chains

Martina Iulini
Valentina Galbiati
Marina Marinovich
Emanuela Corsini

Frontiers in Toxicology

doi 10.3389/ftox.2025.1665163

2,049 views
2 citations

Systematic Review

Published on 19 Nov 2025

Systematic literature review and meta-analysis on the reproductive effects of micro- pollutants in humans and animals

Luca Coppeta
Cristiana Ferrari
Lorenzo Ippoliti
Luisa Campagnolo
Andrea Magrini

Frontiers in Toxicology

doi 10.3389/ftox.2025.1671098

1,583 views

Original Research

Published on 17 Nov 2025

Toxicity effects of cadmium and β-cypermethrin on zebrafish by single and combined exposure: oxidative stress and histopathological evaluation

Xinkun Fu
Suxian Yang
Yi Zhang
Kai Luo
Yonglin Sun
Yuqi Li

Frontiers in Toxicology

doi 10.3389/ftox.2025.1674140

1,207 views

Case Report

Published on 14 Nov 2025

Medium cut-off membrane expanded hemodialysis for Lithium removal: a case report

Katia M. Pérez del Valle
María Moran Magro
Daniel Gaitán Tocora
Nerea Begoña Boldoba
Carmen Benito Puncel
Alberto Silva Obregón
José R. Rodríguez Palomares
Gabriel de Arriba de la Fuente

Frontiers in Toxicology

doi 10.3389/ftox.2025.1677299

1,375 views
2 citations

Opinion

Published on 14 Nov 2025

Revisiting 3Rs: rethinking replacement and new approach methodologies

Jessica Rosolowski
Tilo Weber
Atena Malakpour-Permlid
Stina Oredsson

Frontiers in Toxicology

doi 10.3389/ftox.2025.1664209

1,560 views
1 citation

645 Publications

volumes

Volume 7 - 2025

Mechanistic read-across comes of age: a comparative appraisal of EFSA 2025 guidance, ECHA’s RAAF, and good read-across practice

Correction: The impact of perfumes and cosmetic products on human health: a narrative review

Enhancing allergenicity risk assessment for novel foods in the EU: insights from the updated EFSA guidance - requirements, knowledge gaps and research needs

Comparative evaluation of artificial saliva and complete artificial saliva as solvent vehicles for in vitro toxicity testing of oral tobacco products

Cortical microstructural change linked to clinical recovery in subacute delayed encephalopathy after acute carbon monoxide poisoning: a longitudinal case report

Thai rice instant granules containing turmeric extract and Phyllanthus emblica fruit pulp: Chronic toxicity and antioxidant profiles in rats and in silico investigation of bioactive compounds

Wild mushroom poisoning in Mengzi city, Yunnan province, China, 2018–2023: an analysis through epidemiological characteristics and time series analysis with SARIMA and holt-winters models

Monocyte migration assay using a vascular-on-a-chip model and its utilization for the evaluation of a heated tobacco product

Simulation of microplastic transport and dispersion based on a three-dimensional hydrodynamic particle-tracking model in the Beibu Gulf

Retrospective analysis of clinical laboratory parameters in Han Wistar rat controls

Advancements in the in vitro culture of human pluripotent stem cells: progress, challenges, and future directions: comprehensive review

Unseen contaminants in Portuguese reservoirs: linking microplastics to ecological potential and human pressures

Hazard identification and characterization of leachable chemicals from plastic products – a new PARC project

AlCl3 exposure induces nephrotoxicity in mice by mediating ferroptosis through the NRF2 signaling pathway

Cadmium and glyphosate jointly compromise sperm function, fertilization, and early development in Prochilodus magdalenae

Endocrine disruption rewards: bisphenol-A-induced reproductive toxicity and the precision ameliorative potential of flavonoids in preclinical studies. A systematic review and meta-analysis

Nose-to-brain translocation of inhaled ultrafine elongated particles: facts and mysteries

A new type of ultrasonic water alleviates constipation with favorable safety

Overall effects of microplastics on brain

Decoding PFAS immunotoxicity: a NAMs-based comparison of short vs. long chains

Systematic literature review and meta-analysis on the reproductive effects of micro- pollutants in humans and animals

Toxicity effects of cadmium and β-cypermethrin on zebrafish by single and combined exposure: oxidative stress and histopathological evaluation

Medium cut-off membrane expanded hemodialysis for Lithium removal: a case report

Revisiting 3Rs: rethinking replacement and new approach methodologies