Frontiers in Toxicology

Original Research

Published on 04 Aug 2025

Refinement of a workflow for human relevance assessment of adverse outcome pathways and associated new approach methodologies

Annick D. van den Brand
Julia J. Meerman
Christina H. J. Veltman
Mirjam Luijten

Frontiers in Toxicology

doi 10.3389/ftox.2025.1616817

2,062 views

Case Report

Published on 31 Jul 2025

Case Report: Successful management of severe suicidal lamotrigine overdose-induced status epilepticus with sustained low-efficiency dialysis

Naoki Kawahara
Hiroki Matsui
Koji Morishita

Frontiers in Toxicology

doi 10.3389/ftox.2025.1622752

7,607 views
1 citation

Original Research

Published on 30 Jul 2025

Research on the impact of graphene oxide in feed on growth and health parameters in calves

Tereza Aulichova
Sylvie Skalickova
Kopec Tomas
Pompido Chilala
Pavel Horky

Frontiers in Toxicology

doi 10.3389/ftox.2025.1560078

2,243 views
1 citation

Original Research

Published on 23 Jul 2025

Cadmium decreases human gingival fibroblast viability and induces pro-inflammatory response associated with Akt and MAPK pathway activation

Tipparat Parakaw
Sirada Srihirun
Nathawut Sibmooh
Nisarat Ruangsawasdi
Phisit Khemawoot
Pornpun Vivithanaporn

Frontiers in Toxicology

doi 10.3389/ftox.2025.1583865

2,555 views
1 citation

Original Research

Published on 22 Jul 2025

A deep-learning approach to predict reproductive toxicity of chemicals using communicative message passing neural network

Owen He
Daoxing Chen
Yimei Li

Frontiers in Toxicology

doi 10.3389/ftox.2025.1640612

3,420 views
2 citations

Perspective

Published on 17 Jul 2025

Stress convulsions in rodents: within a weight-of-evidence framework for human seizure risk

Joseph J. DeGeorge
Monica R. Metea

Frontiers in Toxicology

doi 10.3389/ftox.2025.1600816

1,911 views

Original Research

Published on 15 Jul 2025

Chain length-dependent mitochondrial toxicity of perfluoroalkyl carboxylic acids: insights from Mito Tox Index evaluation

Yoonseok Kam
Lisa Winer
Natalia Romero

Frontiers in Toxicology

doi 10.3389/ftox.2025.1582891

2,974 views
4 citations

Original Research

Published on 14 Jul 2025

Subchronic effects of HgCl2 on cognitive function and central inflammation in type 2 diabetic rats: involvement of BDNF and acetylcholinesterase

Douae Benloughmari
Samir Bikri
Meriam El Aboubi
Fatima-Zahra Yassif
Youssef Aboussaleh

Frontiers in Toxicology

doi 10.3389/ftox.2025.1610720

1,984 views

Original Research

Published on 10 Jul 2025

Arsenic toxicity in the Drosophila brain at single cell resolution

Anurag Chaturvedi
Vijay Shankar
Bibhu Simkhada
Rachel A. Lyman
Patrick Freymuth
Elisabeth Howansky
Katelynne M. Collins
Trudy F. C. Mackay
Robert R. H. Anholt

Frontiers in Toxicology

doi 10.3389/ftox.2025.1636431

3,077 views

Review

Published on 10 Jul 2025

25 years of research and regulation: Is nanotechnology safe to commercialize?

Kirsten Rasmussen
Phil Sayre
Andrej Kobe
Mar Gonzalez
Hubert Rauscher

Frontiers in Toxicology

doi 10.3389/ftox.2025.1629813

6,081 views
6 citations

Brief Research Report

Published on 07 Jul 2025

Unlocking liver physiology: comprehensive pathway maps for mechanistic understanding

Luiz Ladeira
Anouk Verhoeven
Jonas van Ertvelde
Jian Jiang
Alessio Gamba
Julen Sanz-Serrano
Tamara Vanhaecke
Harm J. Heusinkveld
Ramiro Jover
Mathieu Vinken

Frontiers in Toxicology

doi 10.3389/ftox.2025.1619651

4,103 views
1 citation

Correction

Published on 04 Jul 2025

Correction: Associations of environmental pollution with pro-oxidant, antioxidant and inflammatory markers in pregnant mothers and newborns

Antonin Ambroz
Jiri Klema
Andrea Rossnerova
Alena Milcova
Anna Pastorkova
Jana Pulkrabova
Ondrej Parizek
Veronika Gomersall
Tomas Gramblicka
Jaroslav Zelenka

Frontiers in Toxicology

doi 10.3389/ftox.2025.1650125

1,117 views
1 citation

Original Research

Published on 01 Jul 2025

Tributyl phosphate as a type of environmental endocrine disruptor associated with liver fibrosis: insights from NHANES and in vitro validation

Liwei Yang
Aipeng Ju
Yawen Huang
Huibin Jiang
Jiaming Ye
Wen Qi
Liting Zhou

Frontiers in Toxicology

doi 10.3389/ftox.2025.1623830

2,641 views
1 citation

Original Research

Published on 01 Jul 2025

Toxicity of glyphosate accelerates neurodegeneration in Caenorhabditis elegans model of Alzheimer’s disease

Nisha Rani
Mohammad Mumtaz Alam
Suhel Parvez

Frontiers in Toxicology

doi 10.3389/ftox.2025.1578230

3,117 views
3 citations

Original Research

Published on 30 Jun 2025

An advancement in developmental and reproductive toxicity (DART) risk assessment: evaluation of a bioactivity and exposure-based NAM toolbox

Iris Mueller
Ashraf Abdelkhaliq
Paul Carmichael
Matthew Dent
Marleen Feliksik
Luke Flatt
Jade Houghton
José M. Horcas Nieto
Amer Jamalpoor
Predrag Kukic

Frontiers in Toxicology

doi 10.3389/ftox.2025.1602065

6,231 views
1 citation

Review

Published on 30 Jun 2025

An adverse outcome pathway for cigarette smoke-mediated oxidative stress in plaque formation

Patrudu Makena
Linsey E. Haswell
Michael McEwan
Brian M. Keyser
David E. Smart
Robert Leverette
Kristen Jordan
Damien Breheny
Sarah Baxter-Wright

Frontiers in Toxicology

doi 10.3389/ftox.2025.1554747

2,927 views
2 citations

Systematic Review

Published on 27 Jun 2025

Towards the standardization of human platelet lysate production and its comparison to fetal bovine serum for human hematopoietic cell culture: a scoping review

Shamili Immalaraju
Srishti Goyal
Rukmini Jonnalagadda

Frontiers in Toxicology

doi 10.3389/ftox.2025.1496231

4,225 views
2 citations

Original Research

Published on 25 Jun 2025

New psychoactive substances in roadway crash victims in California

Roy Gerona
Daniel Tomer
Donovan Nielsen
Allyson C. Sage
Deborah French
Juliana Tolles
James Alan Chenoweth

Frontiers in Toxicology

doi 10.3389/ftox.2025.1572324

3,789 views
2 citations

Case Report

Published on 25 Jun 2025

Case Report: Evaluating toxic encephalopathy from occupational 1,2-dichloroethane exposure: magnetic resonance imaging contributions

Jieru Wang
Tianzi Jian
Guangcai Yu
Baotian Kan
Wei Li
Xiangdong Jian

Frontiers in Toxicology

doi 10.3389/ftox.2025.1557995

2,231 views
3 citations

Original Research

Published on 23 Jun 2025

An injectable 2.5% cross-linked polyacrylamide hydrogel (2.5 iPAAG) demonstrates no neurotoxicity in human induced pluripotent stem cells-derived iCell® GlutaNeurons

Peter S. Walmod
Philip Kusk
Nina Jøhnk
Ieva Ankorina-Stark
Anthony Essex

Frontiers in Toxicology

doi 10.3389/ftox.2025.1585430

2,882 views

Original Research

Published on 12 Jun 2025

Bioengineering of novel organotypic 3D human liver tissue model for drug-induced liver injury and toxicity studies

Camden Holm
Joseph Finelli
Mateo Frare
Alex Armento
Seyoum Ayehunie

Frontiers in Toxicology

doi 10.3389/ftox.2025.1574387

3,701 views

Review

Published on 09 Jun 2025

Cannabis concentrate vaping chemistry

Kaelas R. Munger
Killian M. Anreise
Robert M. Strongin

Frontiers in Toxicology

doi 10.3389/ftox.2025.1568207

6,967 views
1 citation

Original Research

Published on 06 Jun 2025

The patterns of dynamic changes in blood toxicant levels, prognosis, and regression in a case of occupational chlorfenapyr exposure

Jianjian Liu
Zhaozhao Shan
Chen Wang
Xiangdong Jian
Baotian Kan
Yingli Ren

Frontiers in Toxicology

doi 10.3389/ftox.2025.1570887

2,249 views

Original Research

Published on 04 Jun 2025

Characterization of medical device constituents and development of duration-based non-cancer threshold of toxicological concern values

Taylor Builee
Todd A. Kennedy
Valériane Levelut
Megan A. Hahn
Stephen Bond
Michael K. Peterson
Frances K. Hsia
Alessia Stornetta
Kristin J. Erickson
Kimberly D. Ehman

Frontiers in Toxicology

doi 10.3389/ftox.2025.1600127

6,925 views
1 citation

646 Publications

volumes

Volume 7 - 2025

Refinement of a workflow for human relevance assessment of adverse outcome pathways and associated new approach methodologies

Case Report: Successful management of severe suicidal lamotrigine overdose-induced status epilepticus with sustained low-efficiency dialysis

Research on the impact of graphene oxide in feed on growth and health parameters in calves

Cadmium decreases human gingival fibroblast viability and induces pro-inflammatory response associated with Akt and MAPK pathway activation

A deep-learning approach to predict reproductive toxicity of chemicals using communicative message passing neural network

Stress convulsions in rodents: within a weight-of-evidence framework for human seizure risk

Chain length-dependent mitochondrial toxicity of perfluoroalkyl carboxylic acids: insights from Mito Tox Index evaluation

Subchronic effects of HgCl2 on cognitive function and central inflammation in type 2 diabetic rats: involvement of BDNF and acetylcholinesterase

Arsenic toxicity in the Drosophila brain at single cell resolution

25 years of research and regulation: Is nanotechnology safe to commercialize?

Unlocking liver physiology: comprehensive pathway maps for mechanistic understanding

Correction: Associations of environmental pollution with pro-oxidant, antioxidant and inflammatory markers in pregnant mothers and newborns

Tributyl phosphate as a type of environmental endocrine disruptor associated with liver fibrosis: insights from NHANES and in vitro validation

Toxicity of glyphosate accelerates neurodegeneration in Caenorhabditis elegans model of Alzheimer’s disease

An advancement in developmental and reproductive toxicity (DART) risk assessment: evaluation of a bioactivity and exposure-based NAM toolbox

An adverse outcome pathway for cigarette smoke-mediated oxidative stress in plaque formation

Towards the standardization of human platelet lysate production and its comparison to fetal bovine serum for human hematopoietic cell culture: a scoping review

New psychoactive substances in roadway crash victims in California

Case Report: Evaluating toxic encephalopathy from occupational 1,2-dichloroethane exposure: magnetic resonance imaging contributions

An injectable 2.5% cross-linked polyacrylamide hydrogel (2.5 iPAAG) demonstrates no neurotoxicity in human induced pluripotent stem cells-derived iCell® GlutaNeurons

Bioengineering of novel organotypic 3D human liver tissue model for drug-induced liver injury and toxicity studies

Cannabis concentrate vaping chemistry

The patterns of dynamic changes in blood toxicant levels, prognosis, and regression in a case of occupational chlorfenapyr exposure

Characterization of medical device constituents and development of duration-based non-cancer threshold of toxicological concern values